Pivalic acid

Pivalic acid is a lipid of Fatty Acyls (FA) class. Pivalic acid is associated with abnormalities such as Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Otitis Media and Chronic infectious disease. The involved functions are known as carnitine transport, Uptake, inhibitors, Oxidation and Intestinal Absorption. Pivalic acid often locates in Grey line. The related lipids are pivalic acid and Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Pivalic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pivalic acid?

Pivalic acid is suspected in Otitis Media, Renal carnitine transport defect, Carnitine deficiency, Urinary tract infection, Chronic infectious disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pivalic acid

MeSH term MeSH ID Detail
Dihydropyrimidine Dehydrogenase Deficiency D054067 1 associated lipids
Toxocariasis D014120 3 associated lipids
Vitamin B Deficiency D014804 4 associated lipids
Purine-Pyrimidine Metabolism, Inborn Errors D011686 5 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Otitis Media D010033 12 associated lipids
Hyperinsulinism D006946 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Dermatitis D003872 30 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Pivalic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Pivalic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pivalic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pivalic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pivalic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Pivalic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Pivalic acid

Download all related citations
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Authors Title Published Journal PubMed Link
Tong L et al. Development of a prodrug of hydantoin based TACE inhibitor. 2017 Bioorg. Med. Chem. Lett. pmid:28711352
Takahashi Y et al. A case of sudden unexpected infant death involving a homozygotic twin with the thermolabile CPT2 variant, accompanied by rotavirus infection and treatment with an antibiotic containing pivalic acid. 2016 Leg Med (Tokyo) pmid:27591533
Wu DR et al. Additive free preparative chiral SFC separations of 2,2-dimethyl-3-aryl-propanoic acids. 2016 J Pharm Biomed Anal pmid:27522108
Lin Y et al. Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans. 2015 Chem. Commun. (Camb.) pmid:25882587
Yahyaoui R et al. [C5-carnitine false positive results in newborn screening: what is the cause?]. 2015 Med Clin (Barc) pmid:24889749
Boemer F et al. Surprising causes of C5-carnitine false positive results in newborn screening. 2014 Mol. Genet. Metab. pmid:24291264
Srinivas HD et al. Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines. 2014 Org. Lett. pmid:24927013
Witney TH et al. Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection. 2014 J. Nucl. Med. pmid:25012458
Zhou Q et al. In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions. 2014 J. Org. Chem. pmid:24397578
Nasu T et al. Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage. 2014 Pediatr Int pmid:25335995