2,2-DIMETHYLBUTYRIC ACID

2,2-DIMETHYLBUTYRIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Fermentation, Process, Intestinal Absorption, Energy Metabolism and Proteolysis. 2,2-dimethylbutyric acid often locates in host and Hepatic. The related lipids are Propionate, Butyrates, n-Butyrate, Valerates and blood lipid.

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Introduction

To understand associated biological information of 2,2-DIMETHYLBUTYRIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 2,2-DIMETHYLBUTYRIC ACID?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2,2-DIMETHYLBUTYRIC ACID

MeSH term MeSH ID Detail
Gastritis D005756 27 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Sickle Cell Trait D012805 4 associated lipids
beta-Thalassemia D017086 5 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 2,2-DIMETHYLBUTYRIC ACID

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 2,2-DIMETHYLBUTYRIC ACID?

Related references are published most in these journals:

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What functions are associated with 2,2-DIMETHYLBUTYRIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 2,2-DIMETHYLBUTYRIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 2,2-DIMETHYLBUTYRIC ACID?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 2,2-DIMETHYLBUTYRIC ACID?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 2,2-DIMETHYLBUTYRIC ACID

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Authors Title Published Journal PubMed Link
Knapp E et al. Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents. 2016 Am. J. Hematol. pmid:26661045
Dai Y et al. Therapeutic fetal-globin inducers reduce transcriptional repression in hemoglobinopathy erythroid progenitors through distinct mechanisms. 2016 Blood Cells Mol. Dis. pmid:26603726
Mehraei M et al. Target-based drug discovery for [Formula: see text]-globin disorders: drug target prediction using quantitative modeling with hybrid functional Petri nets. 2016 J Bioinform Comput Biol pmid:27431020
Patthamalai P et al. A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia. 2014 Blood pmid:24652964
Reid ME et al. A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. 2014 Am. J. Hematol. pmid:24677033
Inati A et al. A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in β-thalassaemia intermedia. 2014 Br. J. Haematol. pmid:24224649
Kutlar A et al. A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease. 2013 Am. J. Hematol. pmid:23828223
Fucharoen S et al. A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia. 2013 Br. J. Haematol. pmid:23530969
Kutlar A et al. A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. 2012 Am. J. Hematol. pmid:22887019
Bhatia MS et al. Synthesis, characterization and quantification of simvastatin metabolites and impurities. 2011 Jul-Sep Sci Pharm pmid:21886906