|MeSH term||MeSH ID||Detail|
|Leukemia, Myeloid||D007951||52 associated lipids|
|Biliary Fistula||D001658||13 associated lipids|
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
|Disease||Cross reference||Weighted score||Related literature|
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
|Pathway name||Related literatures|
Associated locations are in red color. Not associated locations are in black.
|Function||Cross reference||Weighted score||Related literatures|
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
|Model||Cross reference||Weighted score||Related literatures|
|McHale-Owen H and Bate C||Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-Î² oligomers.||2018||Biochim. Biophys. Acta||pmid:29247837|
|Liu N et al.||Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway.||2017||Org. Lett.||pmid:28605916|
|Liddle E et al.||In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase.||2017||Chem. Commun. (Camb.)||pmid:28106181|
|Lanterna C et al.||The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice.||2016||Cancer Immunol. Immunother.||pmid:27520505|
|Bonsch B et al.||Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues.||2016||Chem. Commun. (Camb.)||pmid:27056201|
|Pastar I et al.||Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration.||2016||J. Cell. Physiol.||pmid:26916741|
|Rondini EA et al.||Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.||2016||J. Pharmacol. Exp. Ther.||pmid:27225895|
|Pant A and Kocarek TA||Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes.||2016||Drug Metab. Dispos.||pmid:26700959|
|Rondini EA et al.||Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes.||2015||J. Pharmacol. Exp. Ther.||pmid:26427720|
|da Silva MF et al.||In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway.||2015||Antimicrob. Agents Chemother.||pmid:26055383|