MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Myeloid | D007951 | 52 associated lipids |
Biliary Fistula | D001658 | 13 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
Michikawa M and Yanagisawa K | Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. | 1999 | Mech. Ageing Dev. | pmid:10360679 |
Gardner RG and Hampton RY | A 'distributed degron' allows regulated entry into the ER degradation pathway. | 1999 | EMBO J. | pmid:10545111 |
Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. | 2000 | Antimicrob. Agents Chemother. | pmid:10817720 |
Ravid T et al. | The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 | J. Biol. Chem. | pmid:10964918 |
Freeman-Cook KD and Halcomb RL | A symmetry-based formal synthesis of zaragozic acid A. | 2000 | J. Org. Chem. | pmid:10987953 |
Hartmann MA et al. | Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. | 2000 | Biochem. Soc. Trans. | pmid:11171211 |
Gardner RG et al. | In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. | 2001 | Mol. Cell. Biol. | pmid:11390656 |
Calter MA and Zhu C | Scope and diastereoselectivity of the "interrupted" Feist-Bénary reaction. | 2002 | Org. Lett. | pmid:11796051 |