| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia, Myeloid | D007951 | 52 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
Total
2
Zaragozic acid A
Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zaragozic acid A?
Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zaragozic acid A
PubChem Associated disorders and diseases
What pathways are associated with Zaragozic acid A
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zaragozic acid A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Zaragozic acid A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zaragozic acid A?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zaragozic acid A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Zaragozic acid A?
Mouse Model
Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zaragozic acid A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| McHale-Owen H and Bate C | Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers. | 2018 | Biochim. Biophys. Acta | pmid:29247837 |
| Liu N et al. | Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. | 2017 | Org. Lett. | pmid:28605916 |
| Liddle E et al. | In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase. | 2017 | Chem. Commun. (Camb.) | pmid:28106181 |
| Lanterna C et al. | The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice. | 2016 | Cancer Immunol. Immunother. | pmid:27520505 |
| Bonsch B et al. | Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues. | 2016 | Chem. Commun. (Camb.) | pmid:27056201 |
| Pastar I et al. | Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. | 2016 | J. Cell. Physiol. | pmid:26916741 |
| Rondini EA et al. | Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27225895 |
| Pant A and Kocarek TA | Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. | 2016 | Drug Metab. Dispos. | pmid:26700959 |
| Rondini EA et al. | Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Intermediates of the Cholesterol Biosynthetic Pathway in Primary Cultured Rat Hepatocytes. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26427720 |
| da Silva MF et al. | In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway. | 2015 | Antimicrob. Agents Chemother. | pmid:26055383 |
| Zúñiga-Hertz JP et al. | Distinct pathways of cholesterol biosynthesis impact on insulin secretion. | 2015 | J. Endocrinol. | pmid:25453115 |
| Bentinger M et al. | Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. | 2014 | Biochim. Biophys. Acta | pmid:24747199 |
| Hamid PH et al. | Differential inhibition of host cell cholesterol de novo biosynthesis and processing abrogates Eimeria bovis intracellular development. | 2014 | Parasitol. Res. | pmid:25199551 |
| Quade-Lyssy P et al. | Statins stimulate the production of a soluble form of the receptor for advanced glycation end products. | 2013 | J. Lipid Res. | pmid:23966666 |
| Liu CI et al. | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase. | 2012 | J. Biol. Chem. | pmid:22474324 |
| Cannell RJ et al. | Follow-up of natural products isolation. | 2012 | Methods Mol. Biol. | pmid:22367909 |
| Fünfschilling U et al. | Critical time window of neuronal cholesterol synthesis during neurite outgrowth. | 2012 | J. Neurosci. | pmid:22649242 |
| Stein W et al. | Prevention of transplant coronary artery disease by prenylation inhibitors. | 2011 | J. Heart Lung Transplant. | pmid:21458297 |
| Henneman L et al. | Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS. | 2011 | Biochim. Biophys. Acta | pmid:21237288 |
| Haeuptle MA et al. | Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid. | 2011 | J. Biol. Chem. | pmid:21183681 |
| Weivoda MM and Hohl RJ | Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. | 2011 | Endocrinology | pmid:21586555 |
| Wang Y and Metz P | A general access to zaragozic acids: total synthesis and structure elucidation of zaragozic acid D and formal syntheses of zaragozic acids A and C. | 2011 | Chemistry | pmid:21328504 |
| Vukelic S et al. | Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor. | 2010 | J. Biol. Chem. | pmid:19903814 |
| Kojro E et al. | Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis. | 2010 | J. Alzheimers Dis. | pmid:20413873 |
| Kahlon AK et al. | Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus. | 2010 | J. Biomol. Struct. Dyn. | pmid:20645653 |
| Linetti A et al. | Cholesterol reduction impairs exocytosis of synaptic vesicles. | 2010 | J. Cell. Sci. | pmid:20103534 |
| Forsman U et al. | 4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures. | 2010 | Nat. Chem. Biol. | pmid:20526342 |
| Paintlia AS et al. | Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. | 2010 | Glia | pmid:20578043 |
| Rothwell C et al. | Cholesterol biosynthesis modulation regulates dengue viral replication. | 2009 | Virology | pmid:19419745 |
| Bedi M et al. | Inhibition of squalene synthase upregulates PCSK9 expression in rat liver. | 2008 | Arch. Biochem. Biophys. | pmid:18054775 |
| Lasserre R et al. | Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. | 2008 | Nat. Chem. Biol. | pmid:18641634 |
| Daicho K et al. | The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. | 2007 | Biochim. Biophys. Acta | pmid:17531951 |
| Brusselmans K et al. | Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. | 2007 | J. Biol. Chem. | pmid:17483544 |
| Wilson R et al. | Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. | 2007 | BMC Neurosci | pmid:18034899 |
| Molina S et al. | The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. | 2007 | J. Hepatol. | pmid:17156886 |
| Schneiders MS et al. | Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. | 2006 | Arthritis Rheum. | pmid:16802371 |
| Hirata Y et al. | Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy. | 2006 | Chemistry | pmid:17106907 |
| Handschin C et al. | Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. | 2005 | Arch. Biochem. Biophys. | pmid:15629111 |
| Tong H et al. | Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. | 2005 | Anal. Biochem. | pmid:15582558 |
| Flury I et al. | INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. | 2005 | EMBO J. | pmid:16270032 |
| Loike JD et al. | Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15345508 |
| Bate C et al. | Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. | 2004 | J. Biol. Chem. | pmid:14754889 |
| Cox RJ et al. | Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis. | 2004 | Chem. Commun. (Camb.) | pmid:15489970 |
| Li HY et al. | Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. | 2003 | Blood | pmid:12506040 |
| Pedretti A et al. | Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. | 2002 | J. Med. Chem. | pmid:11906287 |
| Ourlin JC et al. | A Link between cholesterol levels and phenobarbital induction of cytochromes P450. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11846416 |
| Calter MA and Zhu C | Scope and diastereoselectivity of the "interrupted" Feist-Bénary reaction. | 2002 | Org. Lett. | pmid:11796051 |
| Calter MA et al. | Rapid synthesis of the 7-deoxy zaragozic acid core. | 2002 | Org. Lett. | pmid:11796052 |
| Pandak WM et al. | Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. | 2002 | Hepatology | pmid:12029625 |
| Naito S et al. | Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5. | 2002 | J. Org. Chem. | pmid:12054955 |
| Kocarek TA and Mercer-Haines NA | Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor. | 2002 | Mol. Pharmacol. | pmid:12391282 |
| Wentzinger LF et al. | Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase. | 2002 | Plant Physiol. | pmid:12226513 |
| Gardner RG et al. | In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. | 2001 | Mol. Cell. Biol. | pmid:11390656 |
| Hartmann MA et al. | Metabolism of farnesyl diphosphate in tobacco BY-2 cells treated with squalestatin. | 2000 | Biochem. Soc. Trans. | pmid:11171211 |
| Kaneshiro ES et al. | Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. | 2000 | Antimicrob. Agents Chemother. | pmid:10817720 |
| Ravid T et al. | The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 | J. Biol. Chem. | pmid:10964918 |
| Freeman-Cook KD and Halcomb RL | A symmetry-based formal synthesis of zaragozic acid A. | 2000 | J. Org. Chem. | pmid:10987953 |
| Petras SF et al. | HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. | 1999 | J. Lipid Res. | pmid:9869647 |
| Michikawa M and Yanagisawa K | Apolipoprotein E4 isoform-specific actions on neuronal cells in culture. | 1999 | Mech. Ageing Dev. | pmid:10360679 |
| Gardner RG and Hampton RY | A 'distributed degron' allows regulated entry into the ER degradation pathway. | 1999 | EMBO J. | pmid:10545111 |
| Michikawa M and Yanagisawa K | Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. | 1999 | J. Neurochem. | pmid:10349836 |
| Vaidya S et al. | Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. | 1998 | Arch. Biochem. Biophys. | pmid:9647670 |
| Thompson JF et al. | Truncation of human squalene synthase yields active, crystallizable protein. | 1998 | Arch. Biochem. Biophys. | pmid:9473303 |
| Kocarek TA et al. | Regulation of rat hepatic cytochrome P450 expression by sterol biosynthesis inhibition: inhibitors of squalene synthase are potent inducers of CYP2B expression in primary cultured rat hepatocytes and rat liver. | 1998 | Mol. Pharmacol. | pmid:9730906 |
| Lopez D et al. | Compensatory responses to inhibition of hepatic squalene synthase. | 1998 | Arch. Biochem. Biophys. | pmid:9514656 |
| Corsini A et al. | [Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells]. | 1997 | C. R. Seances Soc. Biol. Fil. | pmid:9255346 |
| Onishi JC et al. | Antimicrobial activity of viridiofungins. | 1997 | J. Antibiot. | pmid:9186560 |
| Pirillo A et al. | Simvastatin modulates the heat shock response and cytotoxicity mediated by oxidized LDL in cultured human endothelial smooth muscle cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070296 |
| Bostedor RG et al. | Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. | 1997 | J. Biol. Chem. | pmid:9083051 |
| Peffley DM and Gayen AK | Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. | 1997 | Arch. Biochem. Biophys. | pmid:9016820 |
| Vlahcevic ZR et al. | Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. | 1997 | Gastroenterology | pmid:9394735 |
| Procopiou PA et al. | The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues. | 1996 | J. Med. Chem. | pmid:8691471 |
| Ness GC et al. | Inhibitors of cholesterol biosynthesis increase hepatic low-density lipoprotein receptor protein degradation. | 1996 | Arch. Biochem. Biophys. | pmid:8561503 |
| Keller RK | Squalene synthase inhibition alters metabolism of nonsterols in rat liver. | 1996 | Biochim. Biophys. Acta | pmid:8908150 |
| Stankewich MC et al. | Alterations in cell cholesterol content modulate Ca(2+)-induced tight junction assembly by MDCK cells. | 1996 | Lipids | pmid:8869884 |
| Chan C et al. | The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. | 1996 | J. Med. Chem. | pmid:8568810 |
| Keller RK et al. | Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. | 1996 | Arch. Biochem. Biophys. | pmid:8645011 |
| Kelly MJ and Roberts SM | Synthetic chemistry. Combating cholesterol. | 1995 | Nature | pmid:7816124 |
| Middleton RF et al. | Novel squalestatins produced by biotransformation. | 1995 | J. Antibiot. | pmid:7775268 |
| Bamford MJ et al. | The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality. | 1995 | J. Med. Chem. | pmid:7658437 |
| Lindsey S and Harwood HJ | Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation. | 1995 | J. Biol. Chem. | pmid:7721822 |
| Doerner KC et al. | Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures. | 1995 | J. Lipid Res. | pmid:7665995 |
| Bergstrom JD et al. | Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. | 1995 | Annu. Rev. Microbiol. | pmid:8561474 |
| Soltis DA et al. | Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. | 1995 | Arch. Biochem. Biophys. | pmid:7864626 |
| Fulton DC et al. | Comparative study of the inhibition of rat and tobacco squalene synthase by squalestatins. | 1995 | Phytochemistry | pmid:7766395 |
| Crick DC et al. | Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1. | 1995 | J. Neurochem. | pmid:7643114 |
| Thelin A et al. | Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids. | 1994 | Biochim. Biophys. Acta | pmid:7811707 |
| Procopiou PA et al. | The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues. | 1994 | J. Med. Chem. | pmid:7932554 |
| Chen TS et al. | The preparation of zaragozic acid A analogues by directed biosynthesis. | 1994 | J. Antibiot. | pmid:8002393 |
| Correll CC and Edwards PA | Mevalonic acid-dependent degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo and in vitro. | 1994 | J. Biol. Chem. | pmid:8276863 |
| Biftu T et al. | Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition. | 1994 | J. Med. Chem. | pmid:8308869 |
| Ponpipom MM et al. | Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. | 1994 | J. Med. Chem. | pmid:7966163 |
| Bansal VS and Vaidya S | Characterization of two distinct allyl pyrophosphatase activities from rat liver microsomes. | 1994 | Arch. Biochem. Biophys. | pmid:7986083 |
| Ness GC et al. | Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by sterols and nonsterols in rat liver. | 1994 | Arch. Biochem. Biophys. | pmid:8109970 |
| Cannell RJ et al. | Production of additional squalestatin analogues by directed biosynthesis. | 1994 | J. Antibiot. | pmid:8150722 |
| Ness GC et al. | Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase. | 1994 | Arch. Biochem. Biophys. | pmid:7911291 |
| Gibbs JB et al. | Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. | 1993 | J. Biol. Chem. | pmid:8463291 |
| Bergstrom JD et al. | Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8419946 |
| Hasumi K et al. | Competitive inhibition of squalene synthetase by squalestatin 1. | 1993 | J. Antibiot. | pmid:8501015 |
| Dufresne C et al. | Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. | 1993 | J. Nat. Prod. | pmid:8289063 |