Zaragozic acid A

Zaragozic acid A is a lipid of Polyketides (PK) class. Zaragozic acid a is associated with abnormalities such as Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity, Atherosclerosis and Infection. The involved functions are known as Anabolism, Sterol Biosynthesis Pathway, isoprenoid biosynthetic process, Biochemical Pathway and Adverse effects. Zaragozic acid a often locates in Endoplasmic reticulum, membrane, viral nucleocapsid location, Cell surface, Hepatic and Membrane. The associated genes with Zaragozic acid A are DPM1 gene, PMM2 gene, STN gene, SLC6A7 gene and Amyloid beta-Protein Precursor. The related lipids are Sterols, Fatty Acids, Membrane Lipids, farnesoic acid and Unilamellar Vesicles. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Zaragozic acid A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Zaragozic acid A?

Zaragozic acid A is suspected in Hypercholesterolemia, Cardiovascular Diseases, Prion Diseases, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular morbidity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Zaragozic acid A

MeSH term MeSH ID Detail
Leukemia, Myeloid D007951 52 associated lipids
Biliary Fistula D001658 13 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Zaragozic acid A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Zaragozic acid A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Zaragozic acid A?

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What functions are associated with Zaragozic acid A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Zaragozic acid A?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Zaragozic acid A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Zaragozic acid A?

Mouse Model

Mouse Model are used in the study 'Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.' (Haeuptle MA et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Zaragozic acid A

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Authors Title Published Journal PubMed Link
Lasserre R et al. Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. 2008 Nat. Chem. Biol. pmid:18641634
Daicho K et al. The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast. 2007 Biochim. Biophys. Acta pmid:17531951
Brusselmans K et al. Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. 2007 J. Biol. Chem. pmid:17483544
Wilson R et al. Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide. 2007 BMC Neurosci pmid:18034899
Molina S et al. The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. 2007 J. Hepatol. pmid:17156886
Schneiders MS et al. Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency. 2006 Arthritis Rheum. pmid:16802371
Hirata Y et al. Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy. 2006 Chemistry pmid:17106907
Handschin C et al. Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. 2005 Arch. Biochem. Biophys. pmid:15629111
Tong H et al. Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. 2005 Anal. Biochem. pmid:15582558
Flury I et al. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. 2005 EMBO J. pmid:16270032