trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

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Introduction

To understand associated biological information of trichostatin A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with trichostatin A?

trichostatin A is suspected in Infection, Morphologically altered structure, Ureteral obstruction, Photosensitization, Atherosclerosis, Hypertrophic Cardiomyopathy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with trichostatin A

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 139

PubChem Associated disorders and diseases

What pathways are associated with trichostatin A

Lipid pathways are not clear in current pathway databases. We organized associated pathways with trichostatin A through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with trichostatin A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with trichostatin A?


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Function Cross reference Weighted score Related literatures

What lipids are associated with trichostatin A?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with trichostatin A?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with trichostatin A?

Mouse Model

Mouse Model are used in the study 'Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.' (Majid S et al., 2010), Mouse Model are used in the study 'Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.' (Fang MZ et al., 2005) and Mouse Model are used in the study 'Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein.' (Kim Y et al., 2012).

Xenograft Model

Xenograft Model are used in the study 'Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.' (Landreville S et al., 2012), Xenograft Model are used in the study 'Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.' (Moiseeva EP et al., 2007) and Xenograft Model are used in the study 'Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model.' (Touma SE et al., 2005).

Cancer Model

Cancer Model are used in the study 'Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.' (Sanderson L et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with trichostatin A

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Per page 10 20 50 100 | Total 3126
Authors Title Published Journal PubMed Link
Liu M et al. Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats. 2018 Toxicology pmid:29902490
Li Q et al. Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. 2018 Endocrinology pmid:29718165
Cribbs A et al. Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. 2018 J. Biol. Chem. pmid:29301935
Cheng YW et al. The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest. 2018 Cell Biochem. Funct. pmid:30484863
Jang B et al. Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones. 2018 J Cancer Res Ther pmid:30249871
Wang Y et al. Inhibition of Histone Deacetylases Prevents Cardiac Remodeling After Myocardial Infarction by Restoring Autophagosome Processing in Cardiac Fibroblasts. 2018 Cell. Physiol. Biochem. pmid:30235443
Feng Y et al. Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy. 2018 Cell. Physiol. Biochem. pmid:30138914
Lugenbiel P et al. Inhibition of Histone Deacetylases Induces K+ Channel Remodeling and Action Potential Prolongation in HL-1 Atrial Cardiomyocytes. 2018 Cell. Physiol. Biochem. pmid:30134221
Wang JH et al. HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells. 2018 Oncol. Rep. pmid:29767267
Shi Y et al. Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs. 2018 Int. J. Mol. Med. pmid:29620153
Jang BG et al. Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells. 2018 J. Mol. Neurosci. pmid:29516351
Zhang X et al. Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. 2018 Oncol. Rep. pmid:29393444
Cai MH et al. Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine. 2018 Sci Rep pmid:29374219
Gao L et al. Histone deacetylase inhibitor trichostatin A and autophagy inhibitor chloroquine synergistically exert anti-tumor activity in H-ras transformed breast epithelial cells. 2018 Mol Med Rep pmid:29344672
Tiffon C Histone Deacetylase Inhibition Restores Expression of Hypoxia-Inducible Protein NDRG1 in Pancreatic Cancer. 2018 Pancreas pmid:29303911
Bodas M et al. Inhibition of histone-deacetylase activity rescues inflammatory cystic fibrosis lung disease by modulating innate and adaptive immune responses. 2018 Respir. Res. pmid:29301535
Seo SK et al. Trichostatin A Induces NAG-1 Expression and Apoptosis in Human Endometriotic Stromal Cells. 2018 Reprod Sci pmid:29157123
Kalaiarasi A et al. Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. 2018 Biotechnol. Lett. pmid:29116558
Lillico R et al. Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. 2018 J. Proteome Res. pmid:29111742
Dalla Pozza E et al. Trichostatin A alters cytoskeleton and energy metabolism of pancreatic adenocarcinoma cells: An in depth proteomic study. 2018 J. Cell. Biochem. pmid:29095525
Xing M et al. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. 2018 Cell Biol. Int. pmid:29064603
Zhang C et al. An epigenetic bioactive composite scaffold with well-aligned nanofibers for functional tendon tissue engineering. 2018 Acta Biomater pmid:28963019
Chan ST et al. Quercetin enhances the antitumor effect of trichostatin A and suppresses muscle wasting in tumor-bearing mice. 2018 Food Funct pmid:29292417
Jayaraman A et al. Amelioration of progressive autoimmune encephalomyelitis by epigenetic regulation involves selective repression of mature neutrophils during the preclinical phase. 2018 Exp. Neurol. pmid:29453977
Wu Y et al. Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity. 2018 Toxicol. Sci. pmid:29301062
Lu Y and Zhang K Cellular Reprogramming in the Retina - Seeing the Light. 2018 N. Engl. J. Med. pmid:29539280
Sun P et al. Effect of trichostatin A on Burkitt's lymphoma cells: Inhibition of EPS8 activity through Phospho-Erk1/2 pathway. 2018 Biochem. Biophys. Res. Commun. pmid:29462617
Motawi TK et al. Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer. 2018 Life Sci. pmid:29455003
Gurgul A et al. Evaluation of changes arising in the pig mesenchymal stromal cells transcriptome following cryopreservation and Trichostatin A treatment. 2018 PLoS ONE pmid:29390033
Wood M et al. Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6. 2018 Arch. Biochem. Biophys. pmid:29233643
Buishand FO et al. Trichostatin A preferentially reverses the upregulation of gene-expression levels induced by gain of chromosome 7 in colorectal cancer cell lines. 2018 Genes Chromosomes Cancer pmid:28940826
Azuma R et al. Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer. 2018 J Vis Exp pmid:29757287
Palazzese L et al. Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts. 2018 PLoS ONE pmid:29543876
Sanaei M et al. Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 Cells 2017 Asian Pac. J. Cancer Prev. pmid:29286617
Takamatsu G et al. Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons. 2017 Biochem. Biophys. Res. Commun. pmid:27939885
Aquea F et al. Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana. 2017 Biochem. Biophys. Res. Commun. pmid:27993678
Shinde V et al. Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox and STOP-Tox tests. 2017 Arch. Toxicol. pmid:27188386
Yeakley JM et al. A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. 2017 PLoS ONE pmid:28542535
Choiniere J et al. Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. 2017 Mol. Pharmacol. pmid:28003426
Porter NJ et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:29203661
Bagheri-Hosseinabadi Z et al. Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor. 2017 Biomed Eng Online pmid:29169361
Lam YM et al. Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo. 2017 Int. J. Hematol. pmid:27531147
Good KV et al. Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. 2017 Epigenetics pmid:29099289
Zhang Z et al. Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride. 2017 Toxicol. Appl. Pharmacol. pmid:29054681
Nagaraja SS et al. Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549 cells. 2017 Biochem. Biophys. Res. Commun. pmid:28993195
Song Y et al. Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis. 2017 Plant Signal Behav pmid:29027833
Zheng C et al. Histone Deacetylase Inhibitors Relax Mouse Aorta Partly through Their Inhibitory Action on L-Type Ca Channels. 2017 J. Pharmacol. Exp. Ther. pmid:28860353
Jorstad NL et al. Stimulation of functional neuronal regeneration from Müller glia in adult mice. 2017 Nature pmid:28746305
Fujikawa J et al. Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes. 2017 Cell Tissue Res. pmid:28856432
Jih G et al. Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription. 2017 Nature pmid:28682306
Jiang F et al. Trichostatin A increases embryo and green plant regeneration in wheat. 2017 Plant Cell Rep. pmid:28752355
Bouzelfen A et al. Heterogeneous epigenetic regulation of HACE1 in Burkitt- Lymphoma-derived cells. 2017 Leuk. Res. pmid:28651105
Jayaraman A et al. The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord. 2017 Neurobiol. Dis. pmid:28736194
Gurgul A et al. The effect of histone deacetylase inhibitor trichostatin A on porcine mesenchymal stem cell transcriptome. 2017 Biochimie pmid:28552396
Ikeda K et al. In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model. 2017 Sci Rep pmid:28300163
Pandey P et al. Dynamics of post-translationally modified histones during barley pollen embryogenesis in the presence or absence of the epi-drug trichostatin A. 2017 Plant Reprod pmid:28526911
Wu Y et al. Suppression of Excessive Histone Deacetylases Activity in Diabetic Hearts Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondria Apoptosis Pathway. 2017 J Diabetes Res pmid:28191472
Vanneste M et al. Hyaluronate synthase-2 overexpression alters estrogen dependence and induces histone deacetylase inhibitor-like effects on ER-driven genes in MCF7 breast tumor cells. 2017 Mol. Cell. Endocrinol. pmid:28137613
Wang XJ et al. Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells. 2017 Cell Rep pmid:28122243
Cao Z et al. TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. 2017 PLoS ONE pmid:28114389
Chen L et al. PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. 2017 Oncotarget pmid:28060760
Campo VA Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression. 2017 Int J Parasitol Drugs Drug Resist pmid:28038431
Alqinyah M et al. Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. 2017 Mol. Pharmacol. pmid:28031332
Mazzio EA and Soliman KF HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. 2017 Cancer Genomics Proteomics pmid:28031235
Duan H et al. The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines. 2017 Placenta pmid:28012453
Mengel A et al. Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases. 2017 Plant Physiol. pmid:27980017
Jia L et al. Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. 2017 Oncol. Rep. pmid:27878285
Huynh NC et al. Histone deacetylase inhibition enhances in-vivo bone regeneration induced by human periodontal ligament cells. 2017 Bone pmid:27871909
Staberg M et al. Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine. 2017 Cell Oncol (Dordr) pmid:27766591
Wittayarat M et al. Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A. 2017 Anim. Sci. J. pmid:27506538
Hrgovic I et al. Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. 2017 Exp. Dermatol. pmid:27487811
Green AL et al. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. 2017 Neuropharmacology pmid:28743636
Zapletal O et al. Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. 2017 Arch. Toxicol. pmid:27830268
Anantharaju PG et al. Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC). 2017 PLoS ONE pmid:29190639
Hartl M et al. Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in . 2017 Mol. Syst. Biol. pmid:29061669
Wei ZQ et al. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. 2017 World J. Gastroenterol. pmid:28974891
Xie C et al. In vitro analysis of factors influencing expression as potential determinants of interindividual variation. 2017 Pharmacol Res Perspect pmid:28357125
Guo Y et al. Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway. 2017 Int. J. Mol. Med. pmid:28849190
Tao LL et al. TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells. 2017 Mol Med Rep pmid:28849174
Kudo K et al. Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. 2017 J. Am. Chem. Soc. pmid:28497964
Lin W et al. Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease. 2017 Kidney Int. pmid:28416226
Zhang XF et al. Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). 2017 Int J Nanomedicine pmid:29075115
Simões-Pires CA et al. Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS. 2017 J Vis Exp pmid:28829415
Ngwa CJ et al. Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite . 2017 Front Cell Infect Microbiol pmid:28791254
Wang SC et al. Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. 2017 Oncol. Rep. pmid:28713892
Pérez-Garrastachu M et al. Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition. 2017 Nucleus pmid:28696859
Opiela J et al. In vitro development and cytological quality of inter-species (porcine→bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of adult mesenchymal stem cells. 2017 Theriogenology pmid:28583605
Hou X et al. HDAC inhibitor TSA ameliorates mechanical hypersensitivity and potentiates analgesic effect of morphine in a rat model of bone cancer pain by restoring μ-opioid receptor in spinal cord. 2017 Brain Res. pmid:28559159
Ilicic M et al. Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium. 2017 Biomed Res Int pmid:28540297
Ma T et al. Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury. 2017 Cell Death Dis pmid:29072686
Duan HY et al. Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line. 2017 Chin. Med. J. pmid:28524836
Androutsopoulos VP and Spandidos DA Antiproliferative effects of TSA, PXD‑101 and MS‑275 in A2780 and MCF7 cells: Acetylated histone H4 and acetylated tubulin as markers for HDACi potency and selectivity. 2017 Oncol. Rep. pmid:29039546
Wei W et al. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. 2017 Cell Res. pmid:28497810
Anantharaju PG et al. Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC). 2017 Cancer Biol. Ther. pmid:28506198
Acun T et al. HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer. 2017 OMICS pmid:28481734
Golfier S et al. High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications. 2017 Cytoskeleton (Hoboken) pmid:28445605
Pachano T et al. Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis. 2017 Cell. Microbiol. pmid:28054438
Cipriano M et al. The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells. 2017 Arch. Toxicol. pmid:27909741
Hichino A et al. Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. 2017 J. Biol. Chem. pmid:28057758
Gilardini Montani MS et al. Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells. 2017 Cell Oncol (Dordr) pmid:28160167