Tautomycetin

Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.

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Introduction

To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tautomycetin?

Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tautomycetin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Tautomycetin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tautomycetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tautomycetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tautomycetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Tautomycetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tautomycetin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Tautomycetin

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Authors Title Published Journal PubMed Link
Ubukata M The logic of biologically active small molecules: amazing ability of microorganisms. 2018 Biosci. Biotechnol. Biochem. pmid:29561233
Choy MS et al. PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. 2017 J. Am. Chem. Soc. pmid:29156132
Choi SS et al. Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412. 2017 J. Ind. Microbiol. Biotechnol. pmid:27734184
Li M et al. TmcN is involved in ATP regulation of tautomycetin biosynthesis in Streptomyces griseochromogenes. 2016 Biochem. Biophys. Res. Commun. pmid:27444385
Tripathi A et al. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. 2016 J. Ind. Microbiol. Biotechnol. pmid:27277081
Stockwell J et al. Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury. 2016 Neuropharmacology pmid:26626486
Gu M et al. Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. 2014 J. Immunol. pmid:24534530
An BC et al. Phosphorylation of the kinase domain regulates autophosphorylation of myosin IIIA and its translocation in microvilli. 2014 Biochemistry pmid:25402663
Niu M et al. Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells. 2013 J. Pharmacol. Sci. pmid:23269238
Nah JH et al. Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412. 2012 Jan-Feb Biotechnol. Adv. pmid:21624452
Yang D et al. Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. 2012 Org. Lett. pmid:22339318
Kim D et al. Biological activities of an engineered tautomycetin analogue via disruption of tmcR-encoding hydroxylase in Streptomyces sp. CK4412. 2012 J. Ind. Microbiol. Biotechnol. pmid:22733296
Kakiya N et al. Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. 2012 J. Biol. Chem. pmid:22767595
Li Y et al. Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. 2012 Biosci. Biotechnol. Biochem. pmid:22451389
Wang F et al. Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin. 2012 J. Microbiol. pmid:23124744
Liu S et al. SHP2 is a target of the immunosuppressant tautomycetin. 2011 Chem. Biol. pmid:21276943
Wee YM et al. The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. 2010 Jul-Aug Mol. Med. pmid:20440443
Walsh JE and Young MR Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. 2010 Anticancer Res. pmid:21187463
Scaglione JB et al. Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. 2010 Angew. Chem. Int. Ed. Engl. pmid:20623733
Luo Y et al. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. 2010 J. Am. Chem. Soc. pmid:20426415