Tautomycetin

Tautomycetin is a lipid of Polyketides (PK) class. Tautomycetin is associated with abnormalities such as Toxic nephropathy and Dehydration. The involved functions are known as Signal, Regulation, Increased Sensitivy, Increased Device Sensitivity and phosphoric monoester hydrolase activity. Tautomycetin often locates in Neurosecretory Systems, Protoplasm, Mitochondria, Transplanted tissue and Blood. The associated genes with Tautomycetin are RAF1 gene, IL2 gene, IL2RA gene, BCL2 gene and cytochrome c''. The related lipids are branched chain fatty acid and Propionate.

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Introduction

To understand associated biological information of Tautomycetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tautomycetin?

Tautomycetin is suspected in Toxic nephropathy, Dehydration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tautomycetin

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Tautomycetin

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Tautomycetin through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tautomycetin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tautomycetin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tautomycetin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Tautomycetin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tautomycetin?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Tautomycetin

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Authors Title Published Journal PubMed Link
Myles DC Novel biologically active natural and unnatural products. 2003 Curr. Opin. Biotechnol. pmid:14662393
Chae WJ et al. T Cell-specific immunosuppression using tautomycetin or PTD-conjugated protein drugs. 2004 Yonsei Med. J. pmid:15627288
Kim JH et al. Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. 2005 Transplant. Proc. pmid:15919517
Lee JH et al. Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. 2006 Mol. Cancer Ther. pmid:17172426
Choi SS et al. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. 2007 Microbiology (Reading, Engl.) pmid:17379718
Swingle M et al. Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. 2007 Methods Mol. Biol. pmid:17200551
Hur YA et al. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. 2008 Microbiology (Reading, Engl.) pmid:18832298
Mitsuhashi S et al. Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation. 2008 Int. J. Oncol. pmid:18949366
Lu Y et al. Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy. 2008 Am. J. Physiol., Cell Physiol. pmid:18094148
Li W et al. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. 2009 J. Nat. Prod. pmid:19191560