Rolliniastatin-1

Rolliniastatin-1 is a lipid of Polyketides (PK) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 351 references associated with Rolliniastatin-1 in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Rolliniastatin-1

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Rolliniastatin-1

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Total 1

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Authors Title Published Journal PubMed Link
López-Gallardo E et al. Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations. 2018 Food Chem. Toxicol. pmid:29991444
Shi JF et al. Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. 2014 Eur J Med Chem pmid:24308999
Masuya T et al. Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry. 2014 Biochemistry pmid:25419630
Chen Y et al. Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds. 2012 J Ethnopharmacol pmid:22609808
Chen Y et al. Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22534655
Nakamaru-Ogiso E et al. The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I. 2010 J. Biol. Chem. pmid:20826797
Kakutani N et al. Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase. 2010 Biochemistry pmid:20459120
Luna-Cazares LM and Gonzalez-Esquinca AR Susceptibility of complete bacteria and spheroplasts of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to rolliniastatin-2. 2010 Nat. Prod. Res. pmid:20582808
Nakamaru-Ogiso E et al. The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. 2010 FEBS Lett. pmid:20074573
Pomper KW et al. Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ). 2009 J. Agric. Food Chem. pmid:19711911
Fato R et al. Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. 2009 Biochim. Biophys. Acta pmid:19059197
Rodrigues dos Santos Lima LA et al. Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia. 2009 Planta Med. pmid:19039734
Liang YJ et al. Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway. 2009 J. Biomed. Biotechnol. pmid:19639048
Sinha SC et al. Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity. 2008 J. Med. Chem. pmid:18975929
Marshall JA and Sabatini JJ An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue. 2006 Org. Lett. pmid:16869659
Zhao H et al. Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin. 2006 Org. Lett. pmid:16956231
Tinsley JM and Roush WR Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes. 2005 J. Am. Chem. Soc. pmid:16076173
Keum G et al. Stereoselective syntheses of rolliniastatin 1, rollimembrin, and membranacin. 2005 J. Am. Chem. Soc. pmid:16028952
Tinsley JM et al. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane. 2005 Org. Lett. pmid:16146398
Hamada T et al. Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I. 2004 Biochemistry pmid:15035635
Chiu HF et al. Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells. 2003 Biochem. Pharmacol. pmid:12527325
Marshall JA et al. A modular synthesis of annonaceous acetogenins. 2003 J. Org. Chem. pmid:12608790
Jiang S et al. Mimicry of annonaceous acetogenins: enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity. 2002 J. Org. Chem. pmid:12003552
Chih HW et al. Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. 2001 Life Sci. pmid:11521756
Tormo JR et al. Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. 2001 Bioorg. Med. Chem. Lett. pmid:11266168
Takada M et al. Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I. 2000 Biochim. Biophys. Acta pmid:11106771
Avedissian H et al. Total synthesis of asimicin and bullatacin. 2000 J. Org. Chem. pmid:10987938
Carelli V et al. Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy. 1999 Ann. Neurol. pmid:10072046
Schuler F et al. NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10097178
Tormo JR et al. Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins. 1999 Arch. Biochem. Biophys. pmid:10462447
Fu LW et al. Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B. 1999 Zhongguo Yao Li Xue Bao pmid:10678092
Okun JG et al. Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). 1999 J. Biol. Chem. pmid:9915790
Shimada H et al. Membrane conformations and their relation to cytotoxicity of asimicin and its analogues. 1998 Biochemistry pmid:9454575
Estornell E et al. Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I). 1997 Biochem. Biophys. Res. Commun. pmid:9367916
Carelli V et al. Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype. 1997 Neurology pmid:9191778
Oberlies NH et al. Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells. 1997 J. Med. Chem. pmid:9207950
Oberlies NH et al. The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. 1997 Cancer Lett. pmid:9097981
Darrouzet E and Dupuis A Genetic evidence for the existence of two quinone related inhibitor binding sites in NADH-CoQ reductase. 1997 Biochim. Biophys. Acta pmid:9107311
Ghelli A et al. Measurement of the membrane potential generated by complex I in submitochondrial particles. 1997 J. Biochem. pmid:9163527
Ye Q et al. Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins. 1996 J. Med. Chem. pmid:8627602
Zhao GX et al. The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba. 1996 Bioorg. Med. Chem. pmid:8689234
Morré DJ et al. Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes. 1995 Life Sci. pmid:7837933
Degli Esposti M et al. Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). 1994 Biochem. J. pmid:8037664
Ahammadsahib KI et al. Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. 1993 Life Sci. pmid:8371627
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