| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
| Parkinsonian Disorders | D020734 | 20 associated lipids |
Epothilone D
Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone D?
Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone D
PubChem Associated disorders and diseases
What pathways are associated with Epothilone D
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone D?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone D?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone D?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone D?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone D
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Chou TC et al. | Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689134 |
| Chou TC et al. | Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9861050 |
| Altmann KH et al. | Synthesis and biological evaluation of highly potent analogues of epothilones B and D. | 2000 | Bioorg. Med. Chem. Lett. | pmid:11133086 |
| Hertweck C | The multiplasmid approach: a new perspective for combinatorial biosynthesis. | 2000 | Chembiochem | pmid:11828403 |
| Altmann KH et al. | Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity. | 2000 | Biochim. Biophys. Acta | pmid:10799747 |
| Mulzer J et al. | Total syntheses of epothilones B and D. | 2000 | J. Org. Chem. | pmid:11076603 |
| Chappell MD et al. | En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B. | 2000 | Org. Lett. | pmid:10841497 |
| Stachel SJ et al. | On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments. | 2000 | Org. Lett. | pmid:10841498 |
| White JD et al. | Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. | 2001 | J. Am. Chem. Soc. | pmid:11389619 |