Epothilone D

Epothilone d is a lipid of Polyketides (PK) class. Epothilone d is associated with abnormalities such as Tauopathies, Neutropenia, Neuropathy and Hematological Disease. The involved functions are known as Mutation, Apoptosis, Mitotic arrest, Cell Growth and Anabolism. Epothilone d often locates in Cytoskeleton, Axon, Cell Wall, Chromosomes and Spindle. The associated genes with epothilone D are SLC33A1 gene, Chromatin, GTF2I gene and HEXA gene.

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Introduction

To understand associated biological information of Epothilone D, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone D?

Epothilone D is suspected in Tauopathies, Neutropenia, Neuropathy, Hematological Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone D

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Alzheimer Disease D000544 76 associated lipids
Neuroblastoma D009447 66 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone D

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone D?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone D?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone D?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone D?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone D?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone D

Download all related citations
Per page 10 20 50 100 | Total 82
Authors Title Published Journal PubMed Link
Pchitskaya EI et al. Dynamic Microtubules in Alzheimer's Disease: Association with Dendritic Spine Pathology. 2018 Biochemistry Mosc. pmid:30472945
Woods LM et al. Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. 2017 Int J Mol Sci pmid:28304361
Haydl AM and Breit B The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies. 2017 Chemistry pmid:27792853
Penazzi L et al. Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. 2016 Neuropharmacology pmid:26772969
Bakota L and Brandt R Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. 2016 Drugs pmid:26729186
Killinger BA and Moszczynska A Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. 2016 J. Neurochem. pmid:26465779
Ye W et al. A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. 2016 J. Ind. Microbiol. Biotechnol. pmid:26803504
Burrell RC et al. Synthesis of stable isotope-labeled epothilone D using a degradation-reconstruction approach. 2015 J Labelled Comp Radiopharm pmid:26158758
Brizuela M et al. The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro. 2015 Mol. Cell. Neurosci. pmid:25684676
Yuan L et al. Use of a carboxylesterase inhibitor of phenylmethanesulfonyl fluoride to stabilize epothilone D in rat plasma for a validated UHPLC-MS/MS assay. 2014 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25151331
Xiong Y et al. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487739
Cartelli D et al. Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. 2013 Sci Rep pmid:23670541
Wang C et al. Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. 2013 Angew. Chem. Int. Ed. Engl. pmid:23307513
Wessjohann LA et al. Total synthesis of epothilone D: the nerol/macroaldolization approach. 2013 J. Org. Chem. pmid:24079664
Sang F et al. Epothilone D and its 9-Methyl analogues: combinatorial syntheses, conformation, and biological activities. 2013 Eur J Med Chem pmid:23994325
Brunden KR et al. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. 2013 ACS Med Chem Lett pmid:24900764
Barten DM et al. Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. 2012 J. Neurosci. pmid:22623658
Brunden KR et al. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. 2012 Biochem. Soc. Trans. pmid:22817712
Zhang B et al. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. 2012 J. Neurosci. pmid:22423084
Fournet V et al. Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice. 2012 J. Neurochem. pmid:23013328