6-deoxyerythronolide B

6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.

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Introduction

To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-deoxyerythronolide B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

What functions are associated with 6-deoxyerythronolide B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 6-deoxyerythronolide B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-deoxyerythronolide B

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Authors Title Published Journal PubMed Link
pmid:
Kennedy J and Kealey JT Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. 2004 Anal. Biochem. pmid:15033515
Khosla C et al. Structure and mechanism of the 6-deoxyerythronolide B synthase. 2007 Annu. Rev. Biochem. pmid:17328673
Fayed B et al. Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis. 2015 Appl. Environ. Microbiol. pmid:26431970
Pfeifer B et al. Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. 2002 Appl. Environ. Microbiol. pmid:12089005
Murli S et al. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. 2005 Appl. Environ. Microbiol. pmid:16085842
Kumpfmüller J et al. Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. 2016 Appl. Microbiol. Biotechnol. pmid:26432460
Wang Y et al. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. 2007 Appl. Microbiol. Biotechnol. pmid:17876579
Yang J et al. Improving heterologous polyketide production in Escherichia coli by transporter engineering. 2015 Appl. Microbiol. Biotechnol. pmid:26062534
Tsai SC et al. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. 2002 Biochemistry pmid:12379102