Kumpfmüller J et al. |
Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. |
2016 |
Appl. Microbiol. Biotechnol. |
pmid:26432460
|
Meng HL et al. |
Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. |
2016 |
Biotechnol J |
pmid:26709503
|
Argyropoulos P et al. |
Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. |
2016 |
Biochim. Biophys. Acta |
pmid:26592346
|
Fayed B et al. |
Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis. |
2015 |
Appl. Environ. Microbiol. |
pmid:26431970
|
Yang J et al. |
Improving heterologous polyketide production in Escherichia coli by transporter engineering. |
2015 |
Appl. Microbiol. Biotechnol. |
pmid:26062534
|
Chen D et al. |
Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field. |
2014 |
PLoS ONE |
pmid:25250723
|
Dechert-Schmitt AM et al. |
Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition. |
2014 |
Nat Prod Rep |
pmid:24514754
|
Gao X et al. |
Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation. |
2013 |
J. Am. Chem. Soc. |
pmid:23464668
|
Pinto A et al. |
6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. |
2012 |
Org. Lett. |
pmid:22519860
|
Yuzawa S et al. |
Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. |
2012 |
Biochemistry |
pmid:22509729
|
He Z et al. |
[Reconstruction of erythromycin macrocyclic lactone synthesis pathway in Escherichia coli]. |
2012 |
Sheng Wu Gong Cheng Xue Bao |
pmid:22667124
|
Boghigian BA et al. |
Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. |
2011 |
J. Ind. Microbiol. Biotechnol. |
pmid:21487833
|
Boghigian BA et al. |
Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. |
2011 |
Biotechnol. Bioeng. |
pmid:21337322
|
Kapur S et al. |
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21127271
|
Zhang H et al. |
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. |
2010 |
Biotechnol. Bioeng. |
pmid:19806677
|
Wu J et al. |
Construction and performance of heterologous polyketide-producing K-12- and B-derived Escherichia coli. |
2010 |
Lett. Appl. Microbiol. |
pmid:20565574
|
Pistorino M and Pfeifer BA |
Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. |
2009 Sep-Oct |
Biotechnol. Prog. |
pmid:19634176
|
Stang EM and White MC |
Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. |
2009 |
Nat Chem |
pmid:21378935
|
Zhang H et al. |
Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. |
2009 |
Microb Biotechnol |
pmid:21261933
|
Khosla C |
Structures and mechanisms of polyketide synthases. |
2009 |
J. Org. Chem. |
pmid:19711990
|
Keatinge-Clay A |
Crystal structure of the erythromycin polyketide synthase dehydratase. |
2008 |
J. Mol. Biol. |
pmid:18952099
|
Wang Y and Pfeifer BA |
6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. |
2008 |
Metab. Eng. |
pmid:17959404
|
Khosla C et al. |
Structure and mechanism of the 6-deoxyerythronolide B synthase. |
2007 |
Annu. Rev. Biochem. |
pmid:17328673
|
Sharma KK and Boddy CN |
The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17428661
|
Wang Y et al. |
Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. |
2007 |
Appl. Microbiol. Biotechnol. |
pmid:17876579
|
Ward SL et al. |
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. |
2007 |
J. Ind. Microbiol. Biotechnol. |
pmid:17033784
|
Akey DL et al. |
Structural basis for macrolactonization by the pikromycin thioesterase. |
2006 |
Nat. Chem. Biol. |
pmid:16969372
|
González-Lergier J et al. |
Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. |
2006 |
Biotechnol. Bioeng. |
pmid:16619212
|
Crimmins MT and Slade DJ |
Formal synthesis of 6-deoxyerythronolide B. |
2006 |
Org. Lett. |
pmid:16671814
|
Murli S et al. |
Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. |
2005 |
Appl. Environ. Microbiol. |
pmid:16085842
|
Desai RP et al. |
Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. |
2004 Jan-Feb |
Biotechnol. Prog. |
pmid:14763821
|
Murli S et al. |
Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. |
2004 |
Biochemistry |
pmid:15595843
|
Ashley GW and Carney JR |
API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. |
2004 |
J. Antibiot. |
pmid:15580959
|
Kennedy J and Kealey JT |
Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. |
2004 |
Anal. Biochem. |
pmid:15033515
|
Lau J et al. |
Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. |
2004 |
J. Biotechnol. |
pmid:15099909
|
Murli S et al. |
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. |
2003 |
J. Ind. Microbiol. Biotechnol. |
pmid:12898389
|
Hu Z et al. |
A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. |
2003 |
Microbiology (Reading, Engl.) |
pmid:12904561
|
Kennedy J et al. |
6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. |
2003 |
Biochemistry |
pmid:14640703
|
Carreras C et al. |
Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. |
2002 |
J. Biotechnol. |
pmid:11689246
|
Paterson I and Temal-Laïb T |
Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. |
2002 |
Org. Lett. |
pmid:12123354
|
Roddis M et al. |
Structural elucidation studies on 14- and 16-membered macrolide aglycones by accurate-mass electrospray sequential mass spectrometry. |
2002 |
J. Am. Soc. Mass Spectrom. |
pmid:12148810
|
Gaisser S et al. |
Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. |
2002 |
Mol. Microbiol. |
pmid:11994157
|
Winn PJ et al. |
Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. |
2002 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:11959989
|
Pfeifer B et al. |
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. |
2002 |
Appl. Environ. Microbiol. |
pmid:12089005
|
Tsai SC et al. |
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. |
2002 |
Biochemistry |
pmid:12379102
|
Lombó F et al. |
Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. |
2001 Jul-Aug |
Biotechnol. Prog. |
pmid:11485419
|
Ferber D |
Microbiology. Possible new route to polyketide synthesis. |
2001 |
Science |
pmid:11253181
|
Tsuji SY et al. |
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. |
2001 |
Biochemistry |
pmid:11327852
|
Pfeifer BA et al. |
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. |
2001 |
Science |
pmid:11230695
|
Kim C et al. |
The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. |
2001 |
Biosci. Biotechnol. Biochem. |
pmid:11388449
|
Yin Y et al. |
Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. |
2001 |
Bioorg. Med. Chem. Lett. |
pmid:11412964
|
Leaf T et al. |
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects. |
2000 Jul-Aug |
Biotechnol. Prog. |
pmid:10933827
|
Wilkinson B et al. |
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. |
2000 |
Chem. Biol. |
pmid:10662692
|
Xiang H et al. |
An A245T mutation conveys on cytochrome P450eryF the ability to oxidize alternative substrates. |
2000 |
J. Biol. Chem. |
pmid:10956654
|
Ziermann R and Betlach MC |
Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains. |
1999 |
BioTechniques |
pmid:9894599
|
Xue Q et al. |
A multiplasmid approach to preparing large libraries of polyketides. |
1999 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10518520
|
Lau J et al. |
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. |
1999 |
Biochemistry |
pmid:9931032
|
Jacobsen JR et al. |
Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. |
1998 |
Biochemistry |
pmid:9538011
|
Rowe CJ et al. |
Construction of new vectors for high-level expression in actinomycetes. |
1998 |
Gene |
pmid:9714812
|
Jacobsen JR et al. |
Precursor-directed biosynthesis of 12-ethyl erythromycin. |
1998 |
Bioorg. Med. Chem. |
pmid:9784859
|
Ju J and Goo YM |
8-Deoxylankolide from a lankamycin producing Streptomyces spp. |
1997 |
J. Antibiot. |
pmid:9315083
|
Jacobsen JR et al. |
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. |
1997 |
Science |
pmid:9219693
|
Chuck JA et al. |
Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. |
1997 |
Chem. Biol. |
pmid:9375254
|
Kao CM et al. |
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase. |
1996 |
Biochemistry |
pmid:8823171
|
Pieper R et al. |
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases. |
1995 |
Nature |
pmid:7477343
|
Cupp-Vickery JR and Poulos TL |
Structure of cytochrome P450eryF involved in erythromycin biosynthesis. |
1995 |
Nat. Struct. Biol. |
pmid:7749919
|
Kao CM et al. |
Engineered biosynthesis of a complete macrolactone in a heterologous host. |
1994 |
Science |
pmid:8036492
|
Cupp-Vickery JR et al. |
Preliminary crystallographic analysis of an enzyme involved in erythromycin biosynthesis: cytochrome P450eryF. |
1994 |
Proteins |
pmid:7846029
|
Donadio S and Katz L |
Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. |
1992 |
Gene |
pmid:1547954
|
Donadio S et al. |
Modular organization of genes required for complex polyketide biosynthesis. |
1991 |
Science |
pmid:2024119
|
Shafiee A and Hutchinson CR |
Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus). |
1987 |
Biochemistry |
pmid:2446657
|
Corcoran JW and Vygantas AM |
Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system. |
1982 |
Biochemistry |
pmid:7074013
|
|
|
|
|
pmid:
|