| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kumpfmüller J et al. | Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis. | 2016 | Appl. Microbiol. Biotechnol. | pmid:26432460 |
| Meng HL et al. | Construction of polyketide overproducing Escherichia coli strains via synthetic antisense RNAs based on in silico fluxome analysis and comparative transcriptome analysis. | 2016 | Biotechnol J | pmid:26709503 |
| Argyropoulos P et al. | Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. | 2016 | Biochim. Biophys. Acta | pmid:26592346 |
| Fayed B et al. | Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis. | 2015 | Appl. Environ. Microbiol. | pmid:26431970 |
| Yang J et al. | Improving heterologous polyketide production in Escherichia coli by transporter engineering. | 2015 | Appl. Microbiol. Biotechnol. | pmid:26062534 |
| Chen D et al. | Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field. | 2014 | PLoS ONE | pmid:25250723 |
| Dechert-Schmitt AM et al. | Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition. | 2014 | Nat Prod Rep | pmid:24514754 |
| Gao X et al. | Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation. | 2013 | J. Am. Chem. Soc. | pmid:23464668 |
| Pinto A et al. | 6-Deoxyerythronolide B synthase thioesterase-catalyzed macrocyclization is highly stereoselective. | 2012 | Org. Lett. | pmid:22519860 |
| Yuzawa S et al. | Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. | 2012 | Biochemistry | pmid:22509729 |
| He Z et al. | [Reconstruction of erythromycin macrocyclic lactone synthesis pathway in Escherichia coli]. | 2012 | Sheng Wu Gong Cheng Xue Bao | pmid:22667124 |
| Boghigian BA et al. | Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21487833 |
| Boghigian BA et al. | Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. | 2011 | Biotechnol. Bioeng. | pmid:21337322 |
| Kapur S et al. | Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21127271 |
| Zhang H et al. | Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. | 2010 | Biotechnol. Bioeng. | pmid:19806677 |
| Wu J et al. | Construction and performance of heterologous polyketide-producing K-12- and B-derived Escherichia coli. | 2010 | Lett. Appl. Microbiol. | pmid:20565574 |
| Pistorino M and Pfeifer BA | Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. | 2009 Sep-Oct | Biotechnol. Prog. | pmid:19634176 |
| Stang EM and White MC | Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation. | 2009 | Nat Chem | pmid:21378935 |
| Zhang H et al. | Probing the heterologous metabolism supporting 6-deoxyerythronolide B biosynthesis in Escherichia coli. | 2009 | Microb Biotechnol | pmid:21261933 |
| Khosla C | Structures and mechanisms of polyketide synthases. | 2009 | J. Org. Chem. | pmid:19711990 |
| Keatinge-Clay A | Crystal structure of the erythromycin polyketide synthase dehydratase. | 2008 | J. Mol. Biol. | pmid:18952099 |
| Wang Y and Pfeifer BA | 6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. | 2008 | Metab. Eng. | pmid:17959404 |
| Khosla C et al. | Structure and mechanism of the 6-deoxyerythronolide B synthase. | 2007 | Annu. Rev. Biochem. | pmid:17328673 |
| Sharma KK and Boddy CN | The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17428661 |
| Wang Y et al. | Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. | 2007 | Appl. Microbiol. Biotechnol. | pmid:17876579 |
| Ward SL et al. | Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. | 2007 | J. Ind. Microbiol. Biotechnol. | pmid:17033784 |
| Akey DL et al. | Structural basis for macrolactonization by the pikromycin thioesterase. | 2006 | Nat. Chem. Biol. | pmid:16969372 |
| González-Lergier J et al. | Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. | 2006 | Biotechnol. Bioeng. | pmid:16619212 |
| Crimmins MT and Slade DJ | Formal synthesis of 6-deoxyerythronolide B. | 2006 | Org. Lett. | pmid:16671814 |
| Murli S et al. | Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. | 2005 | Appl. Environ. Microbiol. | pmid:16085842 |
| Desai RP et al. | Combining classical, genetic, and process strategies for improved precursor-directed production of 6-deoxyerythronolide B analogues. | 2004 Jan-Feb | Biotechnol. Prog. | pmid:14763821 |
| Murli S et al. | Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli. | 2004 | Biochemistry | pmid:15595843 |
| Ashley GW and Carney JR | API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. | 2004 | J. Antibiot. | pmid:15580959 |
| Kennedy J and Kealey JT | Tools for metabolic engineering in Escherichia coli: inactivation of panD by a point mutation. | 2004 | Anal. Biochem. | pmid:15033515 |
| Lau J et al. | Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. | 2004 | J. Biotechnol. | pmid:15099909 |
| Murli S et al. | Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12898389 |
| Hu Z et al. | A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. | 2003 | Microbiology (Reading, Engl.) | pmid:12904561 |
| Kennedy J et al. | 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. | 2003 | Biochemistry | pmid:14640703 |
| Carreras C et al. | Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins. | 2002 | J. Biotechnol. | pmid:11689246 |
| Paterson I and Temal-Laïb T | Toward the combinatorial synthesis of polyketide libraries: asymmetric aldol reactions with alpha-chiral aldehydes on solid support. | 2002 | Org. Lett. | pmid:12123354 |
| Roddis M et al. | Structural elucidation studies on 14- and 16-membered macrolide aglycones by accurate-mass electrospray sequential mass spectrometry. | 2002 | J. Am. Soc. Mass Spectrom. | pmid:12148810 |
| Gaisser S et al. | Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea. | 2002 | Mol. Microbiol. | pmid:11994157 |
| Winn PJ et al. | Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11959989 |
| Pfeifer B et al. | Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. | 2002 | Appl. Environ. Microbiol. | pmid:12089005 |
| Tsai SC et al. | Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. | 2002 | Biochemistry | pmid:12379102 |
| Lombó F et al. | Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. | 2001 Jul-Aug | Biotechnol. Prog. | pmid:11485419 |
| Ferber D | Microbiology. Possible new route to polyketide synthesis. | 2001 | Science | pmid:11253181 |
| Tsuji SY et al. | Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. | 2001 | Biochemistry | pmid:11327852 |
| Pfeifer BA et al. | Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. | 2001 | Science | pmid:11230695 |
| Kim C et al. | The role of serine-246 in cytochrome P450eryF-catalyzed hydroxylation of 6-deoxyerythronolide B. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11388449 |
6-deoxyerythronolide B
6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.
Cross Reference
Introduction
To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 6-deoxyerythronolide B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.
What functions are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 6-deoxyerythronolide B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 6-deoxyerythronolide B?
There are no associated biomedical information in the current reference collection.