6-deoxyerythronolide B

6-deoxyerythronolide B is a lipid of Polyketides (PK) class. The involved functions are known as Anabolism, Biosynthetic Pathways and Synthesis. The associated genes with 6-deoxyerythronolide B are LARGE gene. The related lipids are Propionate.

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Introduction

To understand associated biological information of 6-deoxyerythronolide B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-deoxyerythronolide B

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 6-deoxyerythronolide B through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

What functions are associated with 6-deoxyerythronolide B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-deoxyerythronolide B?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 6-deoxyerythronolide B?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-deoxyerythronolide B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-deoxyerythronolide B

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Authors Title Published Journal PubMed Link
Keatinge-Clay A Crystal structure of the erythromycin polyketide synthase dehydratase. 2008 J. Mol. Biol. pmid:18952099
Wang Y and Pfeifer BA 6-deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. 2008 Metab. Eng. pmid:17959404
Khosla C et al. Structure and mechanism of the 6-deoxyerythronolide B synthase. 2007 Annu. Rev. Biochem. pmid:17328673
Sharma KK and Boddy CN The thioesterase domain from the pimaricin and erythromycin biosynthetic pathways can catalyze hydrolysis of simple thioester substrates. 2007 Bioorg. Med. Chem. Lett. pmid:17428661
Wang Y et al. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. 2007 Appl. Microbiol. Biotechnol. pmid:17876579
Ward SL et al. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. 2007 J. Ind. Microbiol. Biotechnol. pmid:17033784
Akey DL et al. Structural basis for macrolactonization by the pikromycin thioesterase. 2006 Nat. Chem. Biol. pmid:16969372
González-Lergier J et al. Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli. 2006 Biotechnol. Bioeng. pmid:16619212
Crimmins MT and Slade DJ Formal synthesis of 6-deoxyerythronolide B. 2006 Org. Lett. pmid:16671814
Murli S et al. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1. 2005 Appl. Environ. Microbiol. pmid:16085842