tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Genital Diseases, Female D005831 7 associated lipids
Mouth Diseases D009059 5 associated lipids
Meningococcal Infections D008589 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Sugimoto K et al. Assessment of Long-Term Efficacy and Safety of Adalimumab in Patients with Ulcerative Colitis: Results from a 6-Year Real-World Clinical Practice. 2019 Dig Dis pmid:30205400
Shirai T et al. Successful treatment with tacrolimus in TAFRO syndrome: two case reports and literature review. 2018 Medicine (Baltimore) pmid:29879072
Pham TT et al. Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model. 2018 Biomaterials pmid:29128846
Kamanamool N et al. Comparison of disease activity between tacrolimus and mycophenolate mofetil in lupus nephritis: a randomized controlled trial. 2018 Lupus pmid:29105558
Fu J et al. Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis. 2018 Kidney Int. pmid:29102373
Bond MMK et al. Cyclosporine Versus Tacrolimus: Which Calcineurin Inhibitor Has Influence on Cytomegalovirus Infection in Cardiac Transplantation? 2018 Transplant. Proc. pmid:29661443
Lamanna JJ et al. Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord. 2018 J Clin Neurosci pmid:29089163
Zeng K et al. Dissolution Test of Tacrolimus Capsule: Effects of Filtration and Glass Adsorption. 2018 AAPS PharmSciTech pmid:28828626
Kim JP et al. The effect of full dose composite tissue allotransplantation immunosuppression on allograft motor nerve regeneration in a rat sciatic nerve model. 2018 Microsurgery pmid:28792625
Chandran SR et al. A Model of Acute Antibody-Mediated Renal Allograft Rejection in the Sensitized Rata. 2018 Exp Clin Transplant pmid:28760115
Koppelstaetter C et al. Effect of cyclosporine, tacrolimus and sirolimus on cellular senescence in renal epithelial cells. 2018 Toxicol In Vitro pmid:29309803
Lancia P et al. Adverse Events under Tacrolimus and Cyclosporine in the First 3 Years Post-Renal Transplantation in Children. 2018 Clin Drug Investig pmid:29236209
Harada N et al. Serum Asunaprevir and Daclatasvir Concentrations and Outcomes in Patients with Recurrent Hepatitis C Who Have Undergone Living Donor Liver Transplantation. 2018 Anticancer Res. pmid:30194210
Sahu S et al. Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy. 2018 Nanomedicine (Lond) pmid:30188761
Min S et al. A randomized clinical trial of age and genotype-guided tacrolimus dosing after pediatric solid organ transplantation. 2018 Pediatr Transplant pmid:30178515
Zegarska J et al. Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. 2018 Transplant. Proc. pmid:30177142
Karakulska-Prystupiuk E et al. Pericarditis in Patients With Chronic Graft-vs-Host Disease. 2018 Transplant. Proc. pmid:30177139
La Maestra S et al. Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation. 2018 Drug Deliv Transl Res pmid:29869293
Liang TT et al. Modeling Analysis of Potential Target of Dolastatin 16 by Computational Virtual Screening. 2018 Chem. Pharm. Bull. pmid:29863061
Wang JL et al. Delivery of tacrolimus with cationic lipid-assisted nanoparticles for ulcerative colitis therapy. 2018 Biomater Sci pmid:29850666
Marquet P et al. Comparative clinical trial of the variability factors of the exposure indices used for the drug monitoring of two tacrolimus formulations in kidney transplant recipients. 2018 Pharmacol. Res. pmid:29229354
Ling G et al. Mycophenolate Mofetil Alone and in Combination with Tacrolimus Inhibits the Proliferation of HT-29 Human Colonic Adenocarcinoma Cell Line and Might Interfere with Colonic Tumorigenesis. 2018 Anticancer Res. pmid:29848681
Geng L et al. Lower tacrolimus trough levels in the late period after living donor liver transplantation contribute to improvements in long-term clinical outcomes. 2018 HBPD INT pmid:29807766
Zhang T et al. Association of donor small ubiquitin-like modifier 4 rs237025 genetic variant with tacrolimus elimination in the early period after liver transplantation. 2018 Liver Int. pmid:28941036
Moura Neto A et al. Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation. 2018 Transplant. Proc. pmid:29661439
Moura Neto A et al. Clinical Profile of Patients With Diabetes Mellitus and Liver Transplantation: Results After a Multidisciplinary Team Intervention. 2018 Transplant. Proc. pmid:29661438
Crouse L et al. Pyoderma gangrenosum in an infant: A case report and review of the literature. 2018 Pediatr Dermatol pmid:29656404
Grenzi PC et al. Influence of immunosuppressive drugs on the CD30 molecule in kidney transplanted patients. 2018 Hum. Immunol. pmid:29656112
Altwegg R et al. Effectiveness and safety of anti-TNF therapy for inflammatory bowel disease in liver transplant recipients for primary sclerosing cholangitis: A nationwide case series. 2018 Dig Liver Dis pmid:29655972
Freriksen JJM et al. Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue. 2018 Eur J Pharm Sci pmid:29655601
Foroutan A et al. Successful treatment of allergic conjunctival granuloma by topical tacrolimus: A clinicopathologic case report. 2018 Indian J Ophthalmol pmid:29582827
Efe C et al. Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis. 2018 Dig. Dis. Sci. pmid:29569003
Bittersohl H et al. A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples. 2018 J Chromatogr A pmid:29544893
Solomentsev G et al. Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations. 2018 Biochemistry pmid:29412644
Kociszewska-Najman B et al. Low Transfer of Tacrolimus and Its Metabolites into Colostrum of Graft Recipient Mothers. 2018 Nutrients pmid:29495430
Ghadimi M et al. Tacrolimus interaction with oral oestrogen in kidney transplant recipients: A case-control study. 2018 J Clin Pharm Ther pmid:29492991
Li X et al. Association of the PPARγ/PI3K/Akt pathway with the cardioprotective effects of tacrolimus in myocardial ischemic/reperfusion injury. 2018 Mol Med Rep pmid:29488613
Yeh CT et al. Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report. 2018 J Med Case Rep pmid:29486803
Choi HJ et al. Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients. 2018 Drug Des Devel Ther pmid:29483770
Gupta AS et al. Pyoderma Gangrenosum of the Scalp: A Rare Clinical Variant. 2018 Wounds pmid:29481333
Romano P et al. UPLC-MS/MS assay validation for tacrolimus quantitative determination in peripheral blood T CD4+ and B CD19+ lymphocytes. 2018 J Pharm Biomed Anal pmid:29471254
Takeuchi T et al. Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan. 2018 Mod Rheumatol pmid:28649878
Li Y and Feng X Efficacy and safety of tacrolimus in systemic lupus erythematosus patients with refractory thrombocytopenia: a retrospective study. 2018 Lupus pmid:28566017
Wojarski J et al. Immunosuppressive Treatment and Its Effect on the Occurrence of Pneumocystis jiroveci, Mycoplasma pneumoniae, Chlamydophila pnemoniae, and Legionella pneumophila Infections/Colonizations Among Lung Transplant Recipients. 2018 Transplant. Proc. pmid:30177108
Yoshizawa S et al. Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation. 2018 Int J Mol Sci pmid:30142940
Naniwa T et al. Long-term efficacy and safety of add-on tacrolimus for persistent, active rheumatoid arthritis despite treatment with methotrexate and tumor necrosis factor inhibitors. 2018 Int J Rheum Dis pmid:29314738
Li YM et al. Soluble Tim-3 and Gal-9 are associated with renal allograft dysfunction in kidney transplant recipients: A cross-sectional study. 2018 Int. Immunopharmacol. pmid:29310109
Lindström L et al. Risk factors and prognosis for recurrent primary sclerosing cholangitis after liver transplantation: a Nordic Multicentre Study. 2018 Scand. J. Gastroenterol. pmid:29301479
Schutte-Nutgen K et al. Tacrolimus - Pharmacokinetic Considerations for Clinicians. 2018 Curr. Drug Metab. pmid:29298646
Wang HD et al. Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. 2018 Transplantation pmid:29298238