| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mycobacterium Infections | D009164 | 7 associated lipids |
| Sarcoidosis | D012507 | 13 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Hyperglycemia | D006943 | 21 associated lipids |
| Carcinoma, Squamous Cell | D002294 | 14 associated lipids |
| Skin Neoplasms | D012878 | 12 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
tacrolimus
Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.
Cross Reference
Introduction
To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with tacrolimus?
tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (2)
- Am. J. Physiol. Renal Physiol. (1)
- Drug Metab. Dispos. (1)
- Others (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with tacrolimus
PubChem Associated disorders and diseases
What pathways are associated with tacrolimus
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with tacrolimus?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with tacrolimus?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with tacrolimus?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with tacrolimus?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with tacrolimus?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with tacrolimus
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sugimoto K et al. | Assessment of Long-Term Efficacy and Safety of Adalimumab in Patients with Ulcerative Colitis: Results from a 6-Year Real-World Clinical Practice. | 2019 | Dig Dis | pmid:30205400 |
| Shin TH et al. | Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus. | 2018 | Int. J. Biol. Macromol. | pmid:29277422 |
| Moriguchi S et al. | Reduced expression of Na/Ca exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice. | 2018 | Neuropharmacology | pmid:29274751 |
| Copacia JA et al. | 70% Ethanol for Decontamination of Central Venous Lines Exposed to Calcineurin Inhibitors. | 2018 | Ann Pharmacother | pmid:28838253 |
| Gaynor JJ and Ciancio G | The Importance of Using Serially Measured Tacrolimus Clearance Values, Especially During the Early Posttransplantation Period. | 2018 | Transplantation | pmid:29271869 |
| Ohara M et al. | Myasthenia Gravis Complicated with Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS), Following Thymectomy and Longstanding Tacrolimus Therapy. | 2018 | Intern. Med. | pmid:29269644 |
| Hasegawa M et al. | Diagnostic criteria, severity classification and guidelines of lichen sclerosus et atrophicus. | 2018 | J. Dermatol. | pmid:29265410 |
| Gómez-Bravo MA et al. | Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients. | 2018 | Pharmacogenet. Genomics | pmid:29256966 |
| Jha AK et al. | Dermoscopy as an evolving tool to assess vitiligo activity. | 2018 | J. Am. Acad. Dermatol. | pmid:29229577 |
| De Lemos-Bonotto M et al. | A systematic review and meta-analysis of second-line immunosuppressants for autoimmune hepatitis treatment. | 2018 | Eur J Gastroenterol Hepatol | pmid:29227329 |
| Huo T et al. | Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation. | 2018 | Eur J Pharm Sci | pmid:29222025 |
| Gao CJ et al. | Oxymatrine Sensitizes the HaCaT Cells to the IFN-γ Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt. | 2018 | Inflammation | pmid:29218605 |
| Nakahara T et al. | Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis. | 2018 | Pediatr Allergy Immunol | pmid:29205511 |
| Karagun BS et al. | Eye Movement Disorders Following Allogeneic Bone Marrow Transplantation on FK506 (Tacrolimus) and Ganciclovir. | 2018 | J. Pediatr. Hematol. Oncol. | pmid:28731920 |
| Motta A et al. | Immunohistopathological characterization and the impact of topical immunomodulatory therapy in oral chronic graft-versus-host disease: A pilot study. | 2018 | Oral Dis | pmid:29197137 |
| Leiskau C et al. | Side effects and efficacy of renal sparing immunosuppression in pediatric liver transplantation-A single center matched cohort study. | 2018 | Pediatr Transplant | pmid:29729061 |
| Butler KV et al. | Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity. | 2018 | ACS Synth Biol | pmid:29073761 |
| Kirchhof J et al. | Learned immunosuppressive placebo responses in renal transplant patients. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29610294 |
| Watanabe N et al. | The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. | 2018 | Biopharm Drug Dispos | pmid:29055041 |
| Gupta PC and Ram J | Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. | 2018 | Cornea | pmid:29040120 |
| Banovic F et al. | Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. | 2018 | Vet. Dermatol. | pmid:28990239 |
| Nakamura K et al. | Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model. | 2018 | Transpl. Immunol. | pmid:28988984 |
| Ixtlapale-Carmona X et al. | Graft immunologic events in deceased donor kidney transplant recipients with preformed HLA-donor specific antibodies. | 2018 | Transpl. Immunol. | pmid:28974434 |
| Li YM et al. | Impact of immunosuppressive drugs on circulating Tfh cells in kidney transplant recipients: A pilot study. | 2018 | Transpl. Immunol. | pmid:28974433 |
| Shuker N et al. | Intrapatient Variability in Tacrolimus Exposure Does Not Predict The Development of Cardiac Allograft Vasculopathy After Heart Transplant. | 2018 | Exp Clin Transplant | pmid:28969528 |
| Bae SC and Lee YH | Comparative efficacy and tolerability of monotherapy with leflunomide or tacrolimus for the treatment of rheumatoid arthritis: a Bayesian network meta-analysis of randomized controlled trials. | 2018 | Clin. Rheumatol. | pmid:28967035 |
| Altieri M et al. | Conversion From Once-Daily Prolonged-Release Tacrolimus to Once-Daily Extended-Release Tacrolimus in Stable Liver Transplant Recipients. | 2018 | Exp Clin Transplant | pmid:28697715 |
| Sakai R et al. | Efficacy and safety of multitarget therapy with cyclophosphamide and tacrolimus for lupus nephritis: a prospective, single-arm, single-centre, open label pilot study in Japan. | 2018 | Lupus | pmid:28683654 |
| Guan XF et al. | Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients. | 2018 | Eur J Drug Metab Pharmacokinet | pmid:28646274 |
| Huang F et al. | Pharmacokinetic Interaction between Faldaprevir and Cyclosporine or Tacrolimus in Healthy Volunteers: A Prospective, Open-Label, Fixed-Sequence, Crossover Study. | 2018 | Basic Clin. Pharmacol. Toxicol. | pmid:29427400 |
| Zhao J et al. | Comparison of different regimens of pimecrolimus 1% cream in the treatment of facial seborrheic dermatitis. | 2018 | J Cosmet Dermatol | pmid:28589618 |
| Shank BR et al. | Interdisciplinary implementation of tacrolimus intravenous standard concentration in hematopoietic stem cell transplantation recipients. | 2018 | J Oncol Pharm Pract | pmid:28554241 |
| González-VÃlchez F et al. | Efficacy and Safety of de Novo and Early Use of Extended-release Tacrolimus in Heart Transplantation. | 2018 | Rev Esp Cardiol (Engl Ed) | pmid:28545984 |
| Fonseca ACRG et al. | Calcineurin is an important factor involved in glucose uptake in human adipocytes. | 2018 | Mol. Cell. Biochem. | pmid:29380240 |
| Almeida-Paulo GN et al. | Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant. | 2018 | Pharmacogenomics J. | pmid:28094348 |
| Felipe C et al. | Adequacy of Initial Everolimus Dose, With and Without Calcineurin Inhibitors, in Kidney Transplant Recipients. | 2018 | Ther Drug Monit | pmid:29271815 |
| Al-Lawati H et al. | Nanomedicine for immunosuppressive therapy: achievements in pre-clinical and clinical research. | 2018 | Expert Opin Drug Deliv | pmid:29261332 |
| Lancia P et al. | Adverse Events under Tacrolimus and Cyclosporine in the First 3 Years Post-Renal Transplantation in Children. | 2018 | Clin Drug Investig | pmid:29236209 |
| Kimura Y et al. | Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. | 2018 | Arch. Toxicol. | pmid:29594315 |
| Vandenbussche C et al. | Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation. | 2018 | Arch. Toxicol. | pmid:29362864 |
| Tillmann FP et al. | Impact of low-dose steroids on HbA1c levels and development of pre-diabetes and NODAT in non-diabetic renal transplant recipients on long-term follow-up. | 2018 | Int Urol Nephrol | pmid:29197933 |
| Zaman M et al. | Application of quasi-emulsification and modified double emulsification techniques for formulation of tacrolimus microsponges. | 2018 | Int J Nanomedicine | pmid:30127605 |
| Asano T et al. | The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report. | 2018 | Medicine (Baltimore) | pmid:30113451 |
| Liu YJ et al. | Pooled analysis of the comparative efficacy between tacrolimus and infliximab for ulcerative colitis. | 2018 | Medicine (Baltimore) | pmid:30095612 |
| Garaix F et al. | Tacrolimus Granules for Oral Suspension as Post-Transplant Immunosuppression in Routine Medical Practice in France: The OPTIMOD Study. | 2018 | Ann. Transplant. | pmid:30093607 |
| Li P et al. | Risk factors for BK virus infection in living-donor renal transplant recipients: a single-center study from China. | 2018 | Ren Fail | pmid:30052479 |
| Thoms S et al. | Tacrolimus inhibits angiogenesis and induces disaggregation of endothelial cells in spheroids - Toxicity testing in a 3D cell culture approach. | 2018 | Toxicol In Vitro | pmid:30048735 |
| Belaiche S et al. | Factors associated with the variability of calcineurin inhibitor blood levels in kidney recipients grafted for more than 1Â year. | 2018 | Fundam Clin Pharmacol | pmid:29069531 |
| Geng L et al. | Lower tacrolimus trough levels in the late period after living donor liver transplantation contribute to improvements in long-term clinical outcomes. | 2018 | HBPD INT | pmid:29807766 |
| Ding CG et al. | Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation. | 2018 | Chin. Med. J. | pmid:29786042 |
| Malakasioti G et al. | Converting immunosuppression from an oral suspension to a granule formulation of tacrolimus in pediatric renal transplant recipients. | 2018 | Pediatr Transplant | pmid:29767471 |
| Wang DD et al. | Population pharmacokinetics of tacrolimus in paediatric systemic lupus erythematosus based on real-world study. | 2018 | J Clin Pharm Ther | pmid:29766530 |
| Rigo-Bonnin R et al. | Different top-down approaches to estimate measurement uncertainty of whole blood tacrolimus mass concentration values. | 2018 | Clin. Biochem. | pmid:29750938 |
| Strohbehn GW et al. | Large-Scale Variability of Inpatient Tacrolimus Therapeutic Drug Monitoring at an Academic Transplant Center: A Retrospective Study. | 2018 | Ther Drug Monit | pmid:29750738 |
| Sablik KA et al. | Tacrolimus intra-patient variability is not associated with chronic active antibody mediated rejection. | 2018 | PLoS ONE | pmid:29746495 |
| Tang JT et al. | A Low Fixed Tacrolimus Starting Dose Is Effective and Safe in Chinese Renal Transplantation Recipients. | 2018 | Ann. Transplant. | pmid:29735966 |
| Cai W et al. | Limited Sampling Strategy for Estimating Mycophenolic Acid Exposure on Day 7 Post-Transplant for Two Mycophenolate Mofetil Formulations Derived From 20 Chinese Renal Transplant Recipients. | 2018 | Transplant. Proc. | pmid:29735215 |
| Chung YW et al. | Tacrolimus-Induced Apoptosis is Mediated by Endoplasmic Reticulum-derived Calcium-dependent Caspases-3,-12 in Jurkat Cells. | 2018 | Transplant. Proc. | pmid:29731088 |
| Lee KH et al. | Distribution of Anti-ABO Immunoglobulin G Subclass and C1q Antibody in ABO-incompatible Kidney Transplantation. | 2018 | Transplant. Proc. | pmid:29731066 |
| Htun YY et al. | CYP3A5*3 Genetic Polymorphism and Tacrolimus Concentration in Myanmar Renal Transplant Patients. | 2018 | Transplant. Proc. | pmid:29731062 |
| Freriksen JJM et al. | Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue. | 2018 | Eur J Pharm Sci | pmid:29655601 |
| Udomkarnjananun S et al. | An Unusual Manifestation of Calcineurin Inhibitor-Induced Pain Syndrome in Kidney Transplantation: A Case Report and Literature Review. | 2018 | Am J Case Rep | pmid:29654227 |
| Krzyżowska K et al. | Which Kidney Transplant Recipients Can Benefit from the Initial Tacrolimus Dose Reduction? | 2018 | Biomed Res Int | pmid:29651435 |
| Nakagita K et al. | Effect of fluconazole on the pharmacokinetics of everolimus and tacrolimus in a heart transplant recipient: Case report. | 2018 | Int J Clin Pharmacol Ther | pmid:29648533 |
| Kaya Z et al. | Tacrolimus-Induced Autoimmune Hemolytic Anemia in a Previously Reported Child With History of Thrombocytopenia Following Liver Transplant. | 2018 | Exp Clin Transplant | pmid:29633932 |
| Nanmoku K et al. | Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus. | 2018 | Transplant. Proc. | pmid:29631750 |
| Thishya K et al. | Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation. | 2018 | PLoS ONE | pmid:29621269 |
| Riva N et al. | Survival Time to Biopsy-Proven Acute Rejection and Tacrolimus Adverse Drug Reactions in Pediatric Liver Transplantation. | 2018 | Ther Drug Monit | pmid:29621122 |
| Youssef A et al. | Angiolymphoid hyperplasia with eosinophilia: a case report. | 2018 | J Med Case Rep | pmid:29606120 |
| Hu R et al. | CYP3A5*3 and ABCB1 61A>G Significantly Influence Dose-adjusted Trough Blood Tacrolimus Concentrations in the First Three Months Post-Kidney Transplantation. | 2018 | Basic Clin. Pharmacol. Toxicol. | pmid:29603629 |
| Mücke VT et al. | Low Serum Levels of (Dihydro-)Ceramides Reflect Liver Graft Dysfunction in a Real-World Cohort of Patients Post Liver Transplantation. | 2018 | Int J Mol Sci | pmid:29587453 |
| Takeuchi K et al. | Comparison of Safety and Efficacy of Tacrolimus versus Infliximab for Active Ulcerative Colitis. | 2018 | Dig Dis | pmid:29050007 |
| Goto T et al. | Prospective observational study on the first 51 cases of peripheral blood stem cell transplantation from unrelated donors in Japan. | 2018 | Int. J. Hematol. | pmid:29027623 |
| Schuh MJ and Massoglia G | Pharmacist Impact on Tacrolimus Serum Concentrations in Liver Transplant Patients. | 2018 | Consult Pharm | pmid:29789048 |
| Davidson HE | Shifting Paradigms in Caring for Older Adults. | 2018 | Consult Pharm | pmid:29789044 |
| Jouve T et al. | Tailoring tacrolimus therapy in kidney transplantation. | 2018 | Expert Rev Clin Pharmacol | pmid:29779413 |
| Romano P et al. | UPLC-MS/MS assay validation for tacrolimus quantitative determination in peripheral blood T CD4+ and B CD19+ lymphocytes. | 2018 | J Pharm Biomed Anal | pmid:29471254 |
| Lloberas N et al. | Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype. | 2018 | Pharmacogenomics | pmid:29469606 |
| Brooks EK et al. | Evaluation of Multiple Linear Regression-Based Limited Sampling Strategies for Enteric-Coated Mycophenolate Sodium in Adult Kidney Transplant Recipients. | 2018 | Ther Drug Monit | pmid:29461443 |
| Chen X et al. | A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. | 2018 | Medicine (Baltimore) | pmid:29668590 |
| Mashiah J et al. | Topical pimecrolimus for paediatric cutaneous mastocytosis. | 2018 | Clin. Exp. Dermatol. | pmid:29460435 |
| Li A et al. | Atopic keratoconjunctivitis: A diagnostic dilemma-a case report. | 2018 | Medicine (Baltimore) | pmid:29668589 |
| Chen ZH et al. | Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats. | 2018 | Transpl. Immunol. | pmid:29454984 |
| Liu J et al. | Donor and recipient P450 gene polymorphisms influence individual pharmacological effects of tacrolimus in Chinese liver transplantation patients. | 2018 | Int. Immunopharmacol. | pmid:29454235 |
| Yu K et al. | Tacrolimus nanoparticles based on chitosan combined with nicotinamide: enhancing percutaneous delivery and treatment efficacy for atopic dermatitis and reducing dose. | 2018 | Int J Nanomedicine | pmid:29317821 |
| Choi CB et al. | Outcomes of multitarget therapy using mycophenolate mofetil and tacrolimus for refractory or relapsing lupus nephritis. | 2018 | Lupus | pmid:29448881 |
| Yoon CH et al. | Topical Tacrolimus 0.03% for Maintenance Therapy in Steroid-Dependent, Recurrent Phlyctenular Keratoconjunctivitis. | 2018 | Cornea | pmid:29309358 |
| Woodworth MH et al. | Tacrolimus concentration to dose ratio in solid organ transplant patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection. | 2018 | Transpl Infect Dis | pmid:29446866 |
| Konma J et al. | Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: A retrospective study. | 2018 | Mod Rheumatol | pmid:29442534 |
| Vosough M and Tehrani SM | Development of a fast HPLC-DAD method for simultaneous quantitation of three immunosuppressant drugs in whole blood samples using intelligent chemometrics resolving of coeluting peaks in the presence of blood interferences. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29241087 |
| Pircher C et al. | A rare case of Epstein-Barr virus-associated hepatosplenic smooth muscle tumors after kidney transplantation. | 2018 | Transpl Infect Dis | pmid:29427352 |
| Hashemian MN et al. | Topical Tacrolimus as Adjuvant Therapy to Corticosteroids in Acute Endothelial Graft Rejection After Penetrating Keratoplasty: A Randomized Controlled Trial. | 2018 | Cornea | pmid:29215395 |
| Yoshizawa S et al. | Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation. | 2018 | Int J Mol Sci | pmid:30142940 |
| Costa D et al. | Human cryptosporidiosis in immunodeficient patients in France (2015-2017). | 2018 | Exp. Parasitol. | pmid:30107154 |
| Yang MY et al. | High rates of secondary non-adherence causes decreased efficacy of 0.1% topical tacrolimus in adult eczema patients: results from a multicenter clinical trial. | 2018 | J Dermatolog Treat | pmid:28670943 |
| Buchholz BM et al. | Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients. | 2018 | World J. Gastroenterol. | pmid:30065563 |
| Wang HD et al. | Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. | 2018 | Transplantation | pmid:29298238 |
| Kono M et al. | False Elevation of the Blood Tacrolimus Concentration, as Assessed by an Affinity Column-mediated Immunoassay (ACMIA), Led to Acute T Cell-mediated Rejection after Kidney Transplantation. | 2018 | Intern. Med. | pmid:29279473 |
| Heppt MV et al. | Frontal Fibrosing Alopecia: A Retrospective Analysis of 72 Patients from a German Academic Center. | 2018 | Facial Plast Surg | pmid:29278862 |
| Dheer D et al. | Tacrolimus: An updated review on delivering strategies for multifarious diseases. | 2018 | Eur J Pharm Sci | pmid:29277665 |