tacrolimus

Tacrolimus is a lipid of Polyketides (PK) class. Tacrolimus is associated with abnormalities such as Renal glomerular disease. The involved functions are known as inhibitors, Fungicidal activity, Metabolic Inhibition, Excretory function and Dephosphorylation. Tacrolimus often locates in Hepatic, Mitochondrial matrix and Inner mitochondrial membrane. The associated genes with Tacrolimus are RHOA gene and BGN gene.

Cross Reference

Introduction

To understand associated biological information of tacrolimus, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with tacrolimus?

tacrolimus is suspected in Renal glomerular disease, Candidiasis, Mycoses, PARKINSON DISEASE, LATE-ONSET, Morphologically altered structure, Skin Diseases, Infectious and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with tacrolimus

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Hypercalcemia D006934 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with tacrolimus

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with tacrolimus?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with tacrolimus?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with tacrolimus?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with tacrolimus?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with tacrolimus?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with tacrolimus

Download all related citations
Per page 10 20 50 100 | Total 15051
Authors Title Published Journal PubMed Link
Jogiraju VK et al. Application of physiologically based pharmacokinetic modeling to predict drug disposition in pregnant populations. 2017 Biopharm Drug Dispos pmid:28474821
Hu YN et al. High-dose calcineurin inhibitor-free everolimus as a maintenance regimen for heart transplantation may be a risk factor for Pneumocystis pneumonia. 2017 Transpl Infect Dis pmid:28425200
Nishimoto M et al. Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation. 2017 Br J Clin Pharmacol pmid:28407449
Moura Penteado LA et al. Evaluation of the effect of tacrolimus on periodontitis induced in rats. 2017 Arch. Oral Biol. pmid:28399470
Desai VCA et al. Comparative Effectiveness of Tacrolimus-Based Steroid Sparing versus Steroid Maintenance Regimens in Kidney Transplantation: Results from Discrete Event Simulation. 2017 Med Decis Making pmid:28384413
Bao LQ et al. Tacrolimus prevents murine cerebral malaria. 2017 Immunology pmid:27546479
Panackal AA et al. Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. 2017 Clin. Infect. Dis. pmid:28011613
Sato K et al. Early post-transplant hyperbilirubinemia is a possible predictive factor for developing neurological complications in pediatric living donor liver transplant patients receiving tacrolimus. 2017 Pediatr Transplant pmid:27804185
Solmaz S et al. Tacrolimus-Induced Diabetic Ketoacidosis After Allogeneic Bone Marrow Transplant. 2017 Exp Clin Transplant pmid:26643544
Baluch A et al. Successful management of Mycobacterium haemophilum lower extremity cutaneous infection in a matched-unrelated donor stem cell transplant recipient. 2017 Transpl Infect Dis pmid:27775824
Chakkera HA et al. Calcineurin Inhibitors: Pharmacologic Mechanisms Impacting Both Insulin Resistance and Insulin Secretion Leading to Glucose Dysregulation and Diabetes Mellitus. 2017 Clin. Pharmacol. Ther. pmid:27804122
Fox BD et al. Tacrolimus Levels Are Not Associated with Risk of Malignancy in Lung Transplant Recipients. 2017 Ann. Transplant. pmid:29133776
Lombardi A et al. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. 2017 Cell Commun. Signal pmid:29132395
Qazi Y et al. Efficacy and Safety of Everolimus Plus Low-Dose Tacrolimus Versus Mycophenolate Mofetil Plus Standard-Dose Tacrolimus in De Novo Renal Transplant Recipients: 12-Month Data. 2017 Am. J. Transplant. pmid:27775865
Arns W et al. Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial. 2017 Transplantation pmid:28658202
Taber DJ et al. Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation. 2017 Transplantation pmid:28658199
Cong M et al. Novel oleyl amine-modified polymannuronic acid micelle loading tacrolimus for therapy of allergic conjunctivitis. 2017 Int. J. Biol. Macromol. pmid:28655660
Suda M et al. Effectiveness of multi-target therapy in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with early-stage interstitial lung disease. 2017 Scand. J. Rheumatol. pmid:28649889
Miyake M et al. Ligand-induced rapid skeletal muscle atrophy in HSA-Fv2E-PERK transgenic mice. 2017 PLoS ONE pmid:28644884
Li X et al. Tacrolimus Monotherapy after Intravenous Methylprednisolone in Adults with Minimal Change Nephrotic Syndrome. 2017 J. Am. Soc. Nephrol. pmid:27807213
Agarwal SK et al. Impact of type of calcineurin inhibitor on post-transplant tuberculosis: Single-center study from India. 2017 Transpl Infect Dis pmid:27775825
Charman C A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - comment. 2017 Br. J. Dermatol. pmid:28858382
Yu Y et al. Tacrolimus downregulates inflammation by regulating pro‑/anti‑inflammatory responses in LPS‑induced keratitis. 2017 Mol Med Rep pmid:28849181
Jin J et al. Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats. 2017 Korean J. Intern. Med. pmid:27688296
Zaza G et al. Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen. 2017 PLoS ONE pmid:28542523
Neustadtl AL et al. Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity. 2017 Neuroreport pmid:28542068
Schulte K et al. Late conversion from tacrolimus to a belatacept-based immuno-suppression regime in kidney transplant recipients improves renal function, acid-base derangement and mineral-bone metabolism. 2017 J. Nephrol. pmid:28540602
Gouvêa ALF et al. BK polyomavirus nephropathy in two kidney transplant patients with distinct diagnostic strategies for BK virus and similar clinical outcomes: two case reports. 2017 J Med Case Rep pmid:28535782
DaSilva I et al. Rituximab for Steroid-Dependent or Frequently Relapsing Idiopathic Nephrotic Syndrome in Adults: A Retrospective, Multicenter Study in Spain. 2017 BioDrugs pmid:28534103
Baron PW et al. Post-Transplant Diabetes Mellitus After Kidney Transplant in Hispanics and Caucasians Treated with Tacrolimus-Based Immunosuppression. 2017 Ann. Transplant. pmid:28533501
Dorr CR et al. CRISPR/Cas9 Genetic Modification of in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism. 2017 Drug Metab. Dispos. pmid:28533324
Miyamoto T et al. Comparison of cyclosporine and tacrolimus combined with mycophenolate mofetil in prophylaxis for graft-versus-host disease after reduced-intensity umbilical cord blood transplantation. 2017 Int. J. Hematol. pmid:27686673
Liu G et al. FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells. 2017 Cell. Mol. Neurobiol. pmid:27572744
Chen B et al. Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder. 2017 Sci Rep pmid:28400553
Shah SZA et al. Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. 2017 Neurotherapeutics pmid:28083805
Woillard JB et al. Population Pharmacokinetics and Bayesian Estimators for Refined Dose Adjustment of a New Tacrolimus Formulation in Kidney and Liver Transplant Patients. 2017 Clin Pharmacokinet pmid:28389935
Koguchi-Yoshioka H et al. Intravenous immunoglobulin contributes to the control of antimelanoma differentiation-associated protein 5 antibody-associated dermatomyositis with palmar violaceous macules/papules. 2017 Br. J. Dermatol. pmid:28346662
Alhamad T et al. Targeting High Calcineurin Inhibitor Levels After Acute Rejection With Less Tremor: A New Strategy. 2017 Transplantation pmid:28422926
Kanate AS et al. Recipient Immune Modulation with Atorvastatin for Acute Graft-versus-Host Disease Prophylaxis after Allogeneic Transplantation. 2017 Biol. Blood Marrow Transplant. pmid:28412518
Shemesh E et al. The Medication Level Variability Index (MLVI) Predicts Poor Liver Transplant Outcomes: A Prospective Multi-Site Study. 2017 Am. J. Transplant. pmid:28321975
Nambu M et al. A calcineurin antifungal strategy with analogs of FK506. 2017 Bioorg. Med. Chem. Lett. pmid:28412204
Karchin JM et al. Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly. 2017 Sci Rep pmid:28287617
Kawamura H et al. Rapid Induction Therapy with Oral Tacrolimus in Elderly Patients with Refractory Ulcerative Colitis Can Easily Lead to Elevated Tacrolimus Concentrations in Blood: A Report of 5 Cases. 2017 Am J Case Rep pmid:28411286
Mizuno H et al. Extranodal NK/T cell lymphoma in a living donor liver transplant recipient. 2017 Ann. Hematol. pmid:28280996
Sadati MS et al. Recalcitrant cases of pyoderma gangrenosum, responding dramatically to systemic tacrolimus. 2017 G Ital Dermatol Venereol pmid:28409579
de Graav GN et al. A Randomized Controlled Clinical Trial Comparing Belatacept With Tacrolimus After De Novo Kidney Transplantation. 2017 Transplantation pmid:28403127
Ito A et al. Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. 2017 Biochem. Genet. pmid:28324194
Sauer R et al. Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution. 2017 J. Neurol. Sci. pmid:28320193
Hayashi Y et al. Neuropathological findings from an autopsied case showing posterior reversible encephalopathy syndrome-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation. 2017 J. Neurol. Sci. pmid:28320172
Sinha A et al. Mycophenolate mofetil is inferior to tacrolimus in sustaining remission in children with idiopathic steroid-resistant nephrotic syndrome. 2017 Kidney Int. pmid:28318625
Genvigir FDV et al. Influence of ABCC2, CYP2C8, and CYP2J2 Polymorphisms on Tacrolimus and Mycophenolate Sodium-Based Treatment in Brazilian Kidney Transplant Recipients. 2017 Pharmacotherapy pmid:28316087
Mertens JS et al. Morphea and Eosinophilic Fasciitis: An Update. 2017 Am J Clin Dermatol pmid:28303481
Xiang DM et al. [The observation of tacrolimus eye drops preventing the early immunological rejection after penetrating keratoplasty for fungal keratitis]. 2017 Zhonghua Yan Ke Za Zhi pmid:28412805
Dhakal P et al. Eculizumab in Transplant-Associated Thrombotic Microangiopathy. 2017 Clin. Appl. Thromb. Hemost. pmid:26259912
Lepelley M et al. [Pharmacokinetic drug interaction between miconazole mucoadhesive tablet and tacrolimus: About 3 case-reports in transplant patients]. 2017 Therapie pmid:28214069
Saeki K et al. Endobronchial Lesions of Mycobacterium abscessus Infection in an Immunocompromised Patient. 2017 Am. J. Respir. Crit. Care Med. pmid:28199133
Manocha GD et al. Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice. 2017 Mol Neurodegener pmid:28196514
Sikma MA et al. High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury. 2017 Eur. J. Clin. Pharmacol. pmid:28132082
Ayar Y et al. Risk Factors Affecting Graft and Patient Survivals After Transplantation From Deceased Donors in a Developing Country: A Single-Center Experience. 2017 Transplant. Proc. pmid:28219583
Pengcheng W et al. Validation of Donor-Specific Tolerance of Intestinal Transplant by a Secondary Heart Transplantation Model. 2017 Exp Clin Transplant pmid:28122485
Keller F et al. Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
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Kannegieter NM et al. The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function. 2017 PLoS ONE pmid:28122021
Unadkat JV et al. Single Implantable FK506 Disk Prevents Rejection in Vascularized Composite Allotransplantation. 2017 Plast. Reconstr. Surg. pmid:28121868
Chapman WC et al. Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation. 2017 Transplantation pmid:28121741
Sukma Dewi I et al. Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation. 2017 PLoS ONE pmid:28125729
Ren L et al. Donors FMO3 polymorphisms affect tacrolimus elimination in Chinese liver transplant patients. 2017 Pharmacogenomics pmid:28084894
Zhu LB et al. Efficacy and Safety of Tacrolimus Versus Cyclophosphamide for Primary Membranous Nephropathy: A Meta-Analysis. 2017 Drugs pmid:28084563
Trunečka P Once-daily tacrolimus in liver transplantation: a 'me-too drug', or a therapeutic advantage. 2017 Curr Opin Organ Transplant pmid:28079558
Riva N et al. Adequate exposure to tacrolimus with sublingual administration in pediatric liver transplant patients. 2017 Int J Clin Pharmacol Ther pmid:28079516
Zhao YT et al. Sensitized signalling between L-type Ca2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes. 2017 Cardiovasc. Res. pmid:28077437
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Li R et al. Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. 2017 Photodermatol Photoimmunol Photomed pmid:27696531
Billing H et al. Single-Nucleotide Polymorphism of CYP3A5 Impacts the Exposure to Tacrolimus in Pediatric Renal Transplant Recipients: A Pharmacogenetic Substudy of the TWIST Trial. 2017 Ther Drug Monit pmid:28030534
Rozen-Zvi B et al. Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation. 2017 Nephrol. Dial. Transplant. pmid:28025383
Xu D et al. Tacrolimus improves proteinuria remission in adults with cyclosporine A-resistant or -dependent minimal change disease. 2017 Nephrology (Carlton) pmid:28035723
Miyazaki D et al. Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases. 2017 Ophthalmology pmid:28017421
Müller F et al. Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. 2017 Eur J Pharm Biopharm pmid:28012989
Ordóñez-Robles M et al. Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources. 2017 Appl. Microbiol. Biotechnol. pmid:28983826
Qi JC et al. Tacrolimus protects vascular endothelial cells from injuries caused by Ox-LDL by regulating endoplasmic reticulum stress. 2017 Eur Rev Med Pharmacol Sci pmid:28975964
Kitazawa F et al. Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation. 2017 Ann. Transplant. pmid:28947731
Dabrowska-Zamojcin E et al. KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus. 2017 Folia Biol. (Praha) pmid:28805561
Hirano Y et al. Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation. 2017 Ann. Transplant. pmid:28798289
Ishida R et al. The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. 2017 Mol. Cancer Res. pmid:28710230
De Majumdar S et al. A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis. 2017 Curr. Mol. Med. pmid:28782485
Kim MJ et al. The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis. 2017 J. Korean Med. Sci. pmid:28776347
Mussin N et al. Sirolimus and Metformin Synergistically Inhibits Colon Cancer In Vitro and In Vivo. 2017 J. Korean Med. Sci. pmid:28776332
Higashi H et al. First successful perinatal management of pregnancy after ABO-incompatible liver transplantation. 2017 World J. Gastroenterol. pmid:28210092
Kalam MA and Alshamsan A Poly (d, l-lactide-co-glycolide) nanoparticles for sustained release of tacrolimus in rabbit eyes. 2017 Biomed. Pharmacother. pmid:28772219
Singh AR et al. Efficacy of steroidal vs non-steroidal agents in oral lichen planus: a randomised, open-label study. 2017 J Laryngol Otol pmid:27917729
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Furukawa T et al. A case of neuromyelitis optica spectrum disorder (NMOSD) with Sjögren's syndrome manifested only brain involvement by preceding parotitis. 2017 Rinsho Shinkeigaku pmid:28132975
Wang Y et al. FK506 protects heart function via increasing autophagy after myocardial infarction in mice. 2017 Biochem. Biophys. Res. Commun. pmid:28965948
Wood LA et al. New tools for "hot-wiring" clathrin-mediated endocytosis with temporal and spatial precision. 2017 J. Cell Biol. pmid:28954824
Veenhof H et al. Clinical Validation of Simultaneous Analysis of Tacrolimus, Cyclosporine A, and Creatinine in Dried Blood Spots in Kidney Transplant Patients. 2017 Transplantation pmid:27906832
Sigurgeirsson B and Luger T A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal - author response. 2017 Br. J. Dermatol. pmid:28940181
Wojciechowski D et al. Mycophenolate Mofetil Withdrawal With Conversion to Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients. 2017 Transplant. Proc. pmid:28923623
Nanmoku K et al. Effective and Safe Reduction of Conventional Immunosuppressants Using Everolimus in Maintenance Kidney Transplant Recipients. 2017 Transplant. Proc. pmid:28923615
Sakassegawa-Naves FE et al. Tacrolimus Ointment for Refractory Posterior Blepharitis. 2017 Curr. Eye Res. pmid:28922018
Tourret J et al. Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli. 2017 Transplantation pmid:27681266
Larche M and McGonagle D A case of resistant spondyloarthritis (SpA) that responded to tacrolimus and mycophenolate treatment initiated at the time of renal transplantation for unrelated renal failure. 2017 Scand. J. Rheumatol. pmid:26971928