Tylosin

Tylosin is a lipid of Polyketides (PK) class. Tylosin is associated with abnormalities such as Mastitis, Bovine, Infection, Bacterial Infections, Arthritis and Ileitis. The involved functions are known as Anabolism, acireductone dioxygenase [iron(II)-requiring] activity, Protein Biosynthesis, Mastitis and Methylation. Tylosin often locates in Ribosomes, Cell Wall, 50S ribosomal subunit, Ribosome Subunits, Large and Ribosome Subunits. The associated genes with Tylosin are Gene Clusters, Genome, resistance genes, Homologous Gene and HM13 gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Tylosin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tylosin?

Tylosin is suspected in Porcine ulcerative spirochetosis, Infection, Liver Abscess, Respiration Disorders, Intestinal Diseases, Mastitis, Bovine and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tylosin

PubChem Associated disorders and diseases

What pathways are associated with Tylosin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tylosin?

Related references are published most in these journals:

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What functions are associated with Tylosin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tylosin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Tylosin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tylosin?

Knock-out

Knock-out are used in the study 'A second tylosin resistance determinant, Erm B, in Arcanobacterium pyogenes.' (Jost BH et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tylosin

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Authors Title Published Journal PubMed Link
Guo X et al. Maize straw decorated with sulfide for tylosin removal from the water. 2018 Ecotoxicol. Environ. Saf. pmid:29355772
Patyra E et al. Development and validation of an LC-MS/MS method for the quantification of tiamulin, trimethoprim, tylosin, sulfadiazine and sulfamethazine in medicated feed. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:29324179
Chen C et al. Effect of composting and soil type on dissipation of veterinary antibiotics in land-applied manures. 2018 Chemosphere pmid:29306199
Zhang B et al. The effects of bio-available copper on macrolide antibiotic resistance genes and mobile elements during tylosin fermentation dregs co-composting. 2018 Bioresour. Technol. pmid:29278844
Zheng W et al. Development and validation of a simple solid-phase extraction method coupled with liquid chromatography-triple quadrupole tandem mass spectrometry for simultaneous determination of lincomycin, tylosin A and tylosin B in royal jelly. 2018 Biomed. Chromatogr. pmid:29164636
Cornejo J et al. Depletion of tylosin residues in feathers, muscle and liver from broiler chickens after completion of antimicrobial therapy. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:29111882
Bhalsod GD et al. Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce. 2018 J. Agric. Food Chem. pmid:29293328
Huang L et al. Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs. 2018 BMC Vet. Res. pmid:30355326
Zhu L et al. Evaluation of the antibacterial activity of tilmicosin-SLN against : in vitro and in vivo studies. 2018 Int J Nanomedicine pmid:30147316
Lemli B et al. Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin. 2018 Molecules pmid:30065238
De Baere S et al. In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix. 2018 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:30016205
Woolums AR et al. Multidrug resistant Mannheimia haemolytica isolated from high-risk beef stocker cattle after antimicrobial metaphylaxis and treatment for bovine respiratory disease. 2018 Vet. Microbiol. pmid:29981701
Guo X et al. Sorption properties of tylosin on four different microplastics. 2018 Chemosphere pmid:29933160
Stromer BS et al. Tylosin sorption to diatomaceous earth described by Langmuir isotherm and Freundlich isotherm models. 2018 Chemosphere pmid:29874766
Müller HC et al. Effects of intermittent feeding of tylosin phosphate during the finishing period on feedlot performance, carcass characteristics, antimicrobial resistance, and incidence and severity of liver abscesses in steers. 2018 J. Anim. Sci. pmid:29718254
Yin Y et al. Iron and manganese oxides modified maize straw to remove tylosin from aqueous solutions. 2018 Chemosphere pmid:29689529
Ishikawa NK et al. Determination of tylosin excretion from sheep to assess tylosin spread to agricultural fields by manure application. 2018 Sci. Total Environ. pmid:29579651
Canning P et al. Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions. 2018 J. Vet. Pharmacol. Ther. pmid:29572923
Dong H et al. Synthesis and characterization of Ag/BiWO/GO composite for the fast degradation of tylosin under visible light. 2018 Environ Sci Pollut Res Int pmid:29442310
Qiu G et al. Macrolide-Resistance Selection in Tibetan Pigs with a High Load of Mycoplasma hyopneumoniae. 2018 Microb. Drug Resist. pmid:29271698
Ling Z et al. Tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics. 2018 J. Vet. Pharmacol. Ther. pmid:29139136
Lowell JE et al. Growth performance, carcass quality, fresh belly characteristics, and commercial bacon slicing yields of growing-finishing pigs fed a subtherapeutic dose of an antibiotic, a natural antimicrobial, or not fed an antibiotic or antimicrobial. 2018 Meat Sci. pmid:29107868
Wang J et al. Pharmacokinetics of tildipirosin in beagle dogs. 2018 J. Vet. Pharmacol. Ther. pmid:28892155
Washington MT et al. Monitoring tylosin and sulfamethazine in a tile-drained agricultural watershed using polar organic chemical integrative sampler (POCIS). 2018 Sci. Total Environ. pmid:28854391
Mohammadsadegh M Impact of intramammary tilmicosin infusion as a dry cow therapy. 2018 J. Vet. Pharmacol. Ther. pmid:28600854
Makarov GI et al. Structural Insight into Interaction between C20 Phenylalanyl Derivative of Tylosin and Ribosomal Tunnel. 2017 Biochemistry Mosc. pmid:28941460
Berman J et al. A randomised clinical trial of a metaphylactic treatment with tildipirosin for bovine respiratory disease in veal calves. 2017 BMC Vet. Res. pmid:28615070
Li B et al. EFFICACY AND SAFETY OF BAN HUANG ORAL LIQUID FOR TREATING BOVINE RESPIRATORY DISEASES. 2017 Afr J Tradit Complement Altern Med pmid:28573221
Krongdang S et al. Multilocus sequence typing, biochemical and antibiotic resistance characterizations reveal diversity of North American strains of the honey bee pathogen Paenibacillus larvae. 2017 PLoS ONE pmid:28467471
Kreizinger Z et al. Antibiotic susceptibility profiles of Mycoplasma synoviae strains originating from Central and Eastern Europe. 2017 BMC Vet. Res. pmid:29149886
Qekwana DN et al. Patterns and predictors of antimicrobial resistance among Staphylococcus spp. from canine clinical cases presented at a veterinary academic hospital in South Africa. 2017 BMC Vet. Res. pmid:28454567
Weber NR et al. Batch medication of intestinal infections in nursery pigs-A randomised clinical trial on the efficacy of treatment strategy, type of antibiotic and bacterial load on average daily weight gain. 2017 Prev. Vet. Med. pmid:28107883
Zhang N et al. Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. 2017 PLoS ONE pmid:28052123
Pérez RA et al. Analysis of macrolide antibiotics in water by magnetic solid-phase extraction and liquid chromatography-tandem mass spectrometry. 2017 J Pharm Biomed Anal pmid:28858671
Lowell AN et al. Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization. 2017 J. Am. Chem. Soc. pmid:28525276
Timsit E et al. Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease. 2017 Res. Vet. Sci. pmid:28231472
De Mil T et al. Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens. 2017 Poult. Sci. pmid:28160001
Sato T et al. Mycoplasma bovis isolates from dairy calves in Japan have less susceptibility than a reference strain to all approved macrolides associated with a point mutation (G748A) combined with multiple species-specific nucleotide alterations in 23S rRNA. 2017 Microbiol. Immunol. pmid:28504455
Hume ME and Donskey CJ Effect of Vancomycin, Tylosin, and Chlortetracycline on Vancomycin-Resistant Enterococcus faecium Colonization of Broiler Chickens During Grow-Out. 2017 Foodborne Pathog. Dis. pmid:28128649
Nowakiewicz A et al. Determination of antimicrobial resistance of Enterococcus strains isolated from pigs and their genotypic characterization by method of amplification of DNA fragments surrounding rare restriction sites (ADSRRS fingerprinting). 2017 J. Med. Microbiol. pmid:28260584
Weinroth MD et al. Rapid Communication: 16S ribosomal ribonucleic acid characterization of liver abscesses in feedlot cattle from three states in the United States. 2017 J. Anim. Sci. pmid:29108068
Zhang YJ et al. Temporal succession of soil antibiotic resistance genes following application of swine, cattle and poultry manures spiked with or without antibiotics. 2017 Environ. Pollut. pmid:28964602
Ruiz VE et al. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity. 2017 Nat Commun pmid:28894149
Hossain A et al. Occurrence, distribution, ecological and resistance risks of antibiotics in surface water of finfish and shellfish aquaculture in Bangladesh. 2017 Chemosphere pmid:28888121
Amachawadi RG et al. Bacterial flora of liver abscesses in crossbred beef cattle and Holstein steers fed finishing diets with or without tylosin. 2017 J. Anim. Sci. pmid:28805921
Sugawara A et al. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. 2017 J. Antibiot. pmid:28559578
Abell KM et al. A mixed treatment comparison meta-analysis of metaphylaxis treatments for bovine respiratory disease in beef cattle. 2017 J. Anim. Sci. pmid:28380607
Teixeira AGV et al. Efficacy of tildipirosin metaphylaxis for the prevention of respiratory disease, otitis and mortality in pre-weaned Holstein calves. 2017 Vet. J. pmid:28093111
Cheng J et al. Microstructure and antioxidative capacity of the microalgae mutant Chlorella PY-ZU1 during tilmicosin removal from wastewater under 15% CO. 2017 J. Hazard. Mater. pmid:27829514
Ling Z et al. Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles. 2017 J. Vet. Pharmacol. Ther. pmid:27687707
Li B et al. Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics. 2017 Biomed. Chromatogr. pmid:27564248
Prats-van der Ham M et al. Molecular resistance mechanisms of Mycoplasma agalactiae to macrolides and lincomycin. 2017 Vet. Microbiol. pmid:29102109
Ray P et al. Fate and Effect of Antibiotics in Beef and Dairy Manure during Static and Turned Composting. 2017 J. Environ. Qual. pmid:28177414
Liu B et al. Copper exposure to soil under single and repeated application: Selection for the microbial community tolerance and effects on the dissipation of antibiotics. 2017 J. Hazard. Mater. pmid:27930997
Qin Y et al. Analysis of sulfonamides, tilmicosin and avermectins residues in typical animal matrices with multi-plug filtration cleanup by liquid chromatography-tandem mass spectrometry detection. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:28410479
Foster DM et al. Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin. 2017 J. Vet. Pharmacol. Ther. pmid:28457009
Zhang L et al. Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with . 2017 J. Vet. Sci. pmid:28385011
Samii SS et al. Effects of limonene on ruminal concentrations, fermentation, and lysine degradation in cattle. 2016 J. Anim. Sci. pmid:27695807
Tereshchenkov AG et al. New Fluorescent Macrolide Derivatives for Studying Interactions of Antibiotics and Their Analogs with the Ribosomal Exit Tunnel. 2016 Biochemistry Mosc. pmid:27908240
Li Y et al. In vitro susceptibility of four antimicrobials against Riemerella anatipestifer isolates: a comparison of minimum inhibitory concentrations and mutant prevention concentrations for ceftiofur, cefquinome, florfenicol, and tilmicosin. 2016 BMC Vet. Res. pmid:27829415
Angell JW et al. Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial. 2016 Vet. Rec. pmid:27450091
Galmozzi CV et al. The Cyanobacterial Ribosomal-Associated Protein LrtA Is Involved in Post-Stress Survival in Synechocystis sp. PCC 6803. 2016 PLoS ONE pmid:27442126
Cernicchiaro N et al. Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America. 2016 J. Anim. Sci. pmid:27136025
Kim J et al. Effects of the Antibiotics Growth Promoter Tylosin on Swine Gut Microbiota. 2016 J. Microbiol. Biotechnol. pmid:26869601
Brown K et al. Antimicrobial growth promoters modulate host responses in mice with a defined intestinal microbiota. 2016 Sci Rep pmid:27929072
Cleary DW et al. Long-term antibiotic exposure in soil is associated with changes in microbial community structure and prevalence of class 1 integrons. 2016 FEMS Microbiol. Ecol. pmid:27495240
Molognoni L et al. Development of a LC-MS/MS method for the simultaneous determination of sorbic acid, natamycin and tylosin in Dulce de leche. 2016 Food Chem pmid:27283692
Canning P et al. Concentrations of tylvalosin and 3-O-acetyltylosin attained in the synovial fluid of swine after administration by oral gavage at 50 and 5 mg/kg. 2016 J. Vet. Pharmacol. Ther. pmid:27086612
Mendoza J et al. Concentrations of tilmicosin in mammary gland secretions of dairy cows following subcutaneous administration of one or two doses of an experimental preparation of tilmicosin and its efficacy against intramammary infections caused by Staphylococcus aureus. 2016 Am. J. Vet. Res. pmid:27580103
Kim E et al. Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin. 2016 J. Nat. Prod. pmid:27453999
Kline A and Pinckney JL Size-selective toxicity effects of the antimicrobial tylosin on estuarine phytoplankton communities. 2016 Environ. Pollut. pmid:27376985
Besserer F et al. Tilmicosin toxicity: a case of accidental human tilmicosin injection managed with calcium, high-dose insulin and intravenous lipid emulsion therapy. 2016 Clin Toxicol (Phila) pmid:27207720
Guo X et al. Sorption of tylosin and sulfamethazine on solid humic acid. 2016 J Environ Sci (China) pmid:27155426
Crepieux T et al. Randomized, non-inferiority trial comparing a nitric oxide releasing solution with a macrolide antibiotic for control of bovine respiratory disease in beef feedlot calves at high-risk of developing respiratory tract disease. 2016 Res. Vet. Sci. pmid:27033936
Confer AW et al. Clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni five days after metaphylactic administration of tildipirosin or tulathromycin. 2016 Am. J. Vet. Res. pmid:27027834
Torres F et al. Pharmacokinetics of tildipirosin in pig tonsils. 2016 J. Vet. Pharmacol. Ther. pmid:26935349
Luby EM et al. Fate and transport of tylosin-resistant bacteria and macrolide resistance genes in artificially drained agricultural fields receiving swine manure. 2016 Sci. Total Environ. pmid:26874610
Rose M et al. A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. 2016 J. Vet. Pharmacol. Ther. pmid:26538405
El-Mahmoudy A and Gheith I The anti-nociceptive potential of tilmicosin against chemical-induced but not thermal-induced pain in mice. 2016 Int J Immunopathol Pharmacol pmid:26519523
El-Ela FI et al. Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. 2016 Res. Vet. Sci. pmid:27663366
Krokidis M et al. The slow dissociation rate of K-1602 contributes to the enhanced inhibitory activity of this novel alkyl-aryl-bearing fluoroketolide. 2016 J Enzyme Inhib Med Chem pmid:25807301
Amarakoon ID et al. Dissipation of Antimicrobials in a Seasonally Frozen Soil after Beef Cattle Manure Application. 2016 J. Environ. Qual. pmid:27695746
Whitehead TR and Cotta MA Examination of the Aerobic Microflora of Swine Feces and Stored Swine Manure. 2016 J. Environ. Qual. pmid:27065407
Amarakoon ID et al. Dissipation of Antimicrobials in Feedlot Manure Compost after Oral Administration versus Fortification after Excretion. 2016 J. Environ. Qual. pmid:27065397
García-Sánchez L et al. Tylosin effect on methanogenesis in an anaerobic biomass from swine wastewater treatment. 2016 Water Sci. Technol. pmid:26819401
Entorf M et al. Comparative erythromycin and tylosin susceptibility testing of streptococci from bovine mastitis. 2016 Vet. Microbiol. pmid:26732695
Xia X et al. Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance. 2015 Sci Rep pmid:26584633
Lu C et al. Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes. 2015 Microb. Cell Fact. pmid:26525981
Nobel YR et al. Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. 2015 Nat Commun pmid:26123276
Dieste-Pérez L et al. Studies on a suitable antibiotic therapy for treating swine brucellosis. 2015 J. Vet. Pharmacol. Ther. pmid:25413993
Amachawadi RG et al. Effects of In-Feed Copper, Chlortetracycline, and Tylosin on the Prevalence of Transferable Copper Resistance Gene, tcrB, Among Fecal Enterococci of Weaned Piglets. 2015 Foodborne Pathog. Dis. pmid:26258261
Sura S et al. Transport of three veterinary antimicrobials from feedlot pens via simulated rainfall runoff. 2015 Sci. Total Environ. pmid:25839178
Sehati N et al. Application of hollow fiber membrane mediated with titanium dioxide nanowire/reduced graphene oxide nanocomposite in preconcentration of clotrimazole and tylosin. 2015 J Chromatogr A pmid:26477522
Blondeau JM et al. Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica. 2015 Am. J. Vet. Res. pmid:26413823
Hao H et al. Microbiological toxicity of tilmicosin on human colonic microflora in chemostats. 2015 Regul. Toxicol. Pharmacol. pmid:26190303
Kilpinen S et al. Oral tylosin administration is associated with an increase of faecal enterococci and lactic acid bacteria in dogs with tylosin-responsive diarrhoea. 2015 Vet. J. pmid:26049259
Whitehead TR et al. Savagea faecisuis gen. nov., sp. nov., a tylosin- and tetracycline-resistant bacterium isolated from a swine-manure storage pit. 2015 Antonie Van Leeuwenhoek pmid:25980832
Li Q et al. Co-addition of manure increases the dissipation rates of tylosin A and the numbers of resistance genes in laboratory incubation experiments. 2015 Sci. Total Environ. pmid:25958362
Abdel-Daim MM et al. Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice. 2015 Can. J. Physiol. Pharmacol. pmid:25429612
Zhu H et al. Immobilization of Streptomyces thermotolerans 11432 on polyurethane foam to improve production of acetylisovaleryltylosin. 2015 J. Ind. Microbiol. Biotechnol. pmid:25413211