minocycline

minocycline is a lipid of Polyketides (PK) class. Minocycline is associated with abnormalities such as Infection, Soft Tissue Infections, Septicemia, Chronic hyponatremia and Lesion of brain. The involved functions are known as Pharmacodynamics, Gene Expression, Transcriptional Activation, Regulation and Process. Minocycline often locates in Ribosomes, 50S ribosomal subunit, Blood, Skin and Immune system. The associated genes with minocycline are THEMIS gene, KCNK2 gene, RBFOX3 gene, PIWIL2 gene and P4HTM gene. The related lipids are Lipopolysaccharides, Promega, Steroids, Liposomes and Octanols. The related experimental models are Mouse Model, Experimental Autoimmune Encephalomyelitis, Genetically Engineered Mouse, Disease model and spinal model.

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Introduction

To understand associated biological information of minocycline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with minocycline?

minocycline is suspected in Infection, Cerebrovascular accident, Ischemia, Huntington Disease, Parkinson Disease, Neurodegenerative Disorders and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with minocycline

MeSH term MeSH ID Detail
Nocardia Infections D009617 6 associated lipids
Diarrhea D003967 32 associated lipids
Maxillary Diseases D008439 3 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Genital Diseases, Female D005831 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with minocycline

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with minocycline?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with minocycline?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with minocycline?

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What genes are associated with minocycline?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with minocycline?

Mouse Model

Mouse Model are used in the study 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.' (Wu DC et al., 2002), Mouse Model are used in the study 'Efficacy of a novel tetracycline derivative, glycylcycline, against penicillin-resistant Streptococcus pneumoniae in a mouse model of pneumonia.' (Murakami K et al., 2000), Mouse Model are used in the study 'Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration.' (Zhang C et al., 2004), Mouse Model are used in the study 'Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism.' (Hayakawa K et al., 2008) and Mouse Model are used in the study 'Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.' (Naura AS et al., 2013).

Experimental Autoimmune Encephalomyelitis

Experimental Autoimmune Encephalomyelitis are used in the study 'Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis.' (Brundula V et al., 2002), Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells.' (Szeto GL et al., 2011), Experimental Autoimmune Encephalomyelitis are used in the study '11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats.' (Converse AK et al., 2011) and Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII.' (Nikodemova M et al., 2007).

Disease model

Disease model are used in the study 'Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite.' (Schildknecht S et al., 2011) and Disease model are used in the study 'Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release.' (Holmkvist AD et al., 2016).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with minocycline

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Per page 10 20 50 100 | Total 5564
Authors Title Published Journal PubMed Link
Rani V et al. Effects of minocycline and doxycycline against terbutaline induced early postnatal autistic changes in albino rats. 2018 Physiol. Behav. pmid:29074392
Hou S et al. Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. 2018 Biomater Sci pmid:29740652
Berkiks I et al. Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats. 2018 Biomed. Pharmacother. pmid:29710462
Bishop EJ et al. The outcome of patients with severe and severe-complicated Clostridium difficile infection treated with tigecycline combination therapy: a retrospective observational study. 2018 Intern Med J pmid:29363242
Savitz JB et al. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. 2018 Transl Psychiatry pmid:29362444
Wixey JA et al. Disruption to the 5-HT Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain. 2018 Neurochem. Res. pmid:29357019
Berkiks I et al. Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress. 2018 Int. J. Neurosci. pmid:29077529
Kengkla K et al. Comparative efficacy and safety of treatment options for MDR and XDR Acinetobacter baumannii infections: a systematic review and network meta-analysis. 2018 J. Antimicrob. Chemother. pmid:29069421
Cheng JW et al. High in vitro activity of fidaxomicin against Clostridium difficile isolates from a university teaching hospital in China. 2018 J Microbiol Immunol Infect pmid:28693926
Pradier M et al. Suppressive antibiotic therapy with oral tetracyclines for prosthetic joint infections: a retrospective study of 78 patients. 2018 Infection pmid:29052797