| MeSH term | MeSH ID | Detail |
|---|---|---|
| Nocardia Infections | D009617 | 6 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Maxillary Diseases | D008439 | 3 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Bacterial Infections | D001424 | 21 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Genital Diseases, Female | D005831 | 7 associated lipids |
minocycline
minocycline is a lipid of Polyketides (PK) class. Minocycline is associated with abnormalities such as Infection, Soft Tissue Infections, Septicemia, Chronic hyponatremia and Lesion of brain. The involved functions are known as Pharmacodynamics, Gene Expression, Transcriptional Activation, Regulation and Process. Minocycline often locates in Ribosomes, 50S ribosomal subunit, Blood, Skin and Immune system. The associated genes with minocycline are THEMIS gene, KCNK2 gene, RBFOX3 gene, PIWIL2 gene and P4HTM gene. The related lipids are Lipopolysaccharides, Promega, Steroids, Liposomes and Octanols. The related experimental models are Mouse Model, Experimental Autoimmune Encephalomyelitis, Genetically Engineered Mouse, Disease model and spinal model.
Cross Reference
Introduction
To understand associated biological information of minocycline, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with minocycline?
minocycline is suspected in Infection, Cerebrovascular accident, Ischemia, Huntington Disease, Parkinson Disease, Neurodegenerative Disorders and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with minocycline
PubChem Associated disorders and diseases
What pathways are associated with minocycline
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with minocycline?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with minocycline?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with minocycline?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with minocycline?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with minocycline?
Mouse Model
Mouse Model are used in the study 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.' (Wu DC et al., 2002), Mouse Model are used in the study 'Efficacy of a novel tetracycline derivative, glycylcycline, against penicillin-resistant Streptococcus pneumoniae in a mouse model of pneumonia.' (Murakami K et al., 2000), Mouse Model are used in the study 'Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration.' (Zhang C et al., 2004), Mouse Model are used in the study 'Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism.' (Hayakawa K et al., 2008) and Mouse Model are used in the study 'Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.' (Naura AS et al., 2013).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis.' (Brundula V et al., 2002), Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells.' (Szeto GL et al., 2011), Experimental Autoimmune Encephalomyelitis are used in the study '11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats.' (Converse AK et al., 2011) and Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII.' (Nikodemova M et al., 2007).
Disease model
Disease model are used in the study 'Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite.' (Schildknecht S et al., 2011) and Disease model are used in the study 'Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release.' (Holmkvist AD et al., 2016).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with minocycline
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berkiks I et al. | Thymelaea lythroides extract attenuates microglial activation and depressive-like behavior in LPS-induced inflammation in adult male rats. | 2018 | Biomed. Pharmacother. | pmid:29710462 |
| Savitz JB et al. | Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. | 2018 | Transl Psychiatry | pmid:29362444 |
| Wixey JA et al. | Disruption to the 5-HT Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain. | 2018 | Neurochem. Res. | pmid:29357019 |
| Ni W et al. | Use of Monte Carlo simulation to evaluate the efficacy of tigecycline and minocycline for the treatment of pneumonia due to carbapenemase-producing Klebsiella pneumoniae. | 2018 | Infect Dis (Lond) | pmid:29316830 |
| Deitchman AN et al. | Enhanced in vitro activity of tigecycline in the presence of chelating agents. | 2018 | Int. J. Antimicrob. Agents | pmid:29305959 |
| Kengkla K et al. | Comparative efficacy and safety of treatment options for MDR and XDR Acinetobacter baumannii infections: a systematic review and network meta-analysis. | 2018 | J. Antimicrob. Chemother. | pmid:29069421 |
| Chang YY et al. | Impact of reduced tigecycline susceptibility on clinical outcomes of Acinetobacter bacteremia. | 2018 | J Microbiol Immunol Infect | pmid:29050749 |
| Kimmitt BA et al. | Comparison of the efficacy of various concentrations and combinations of serum, ethylenediaminetetraacetic acid, tetracycline, doxycycline, minocycline, and N-acetylcysteine for inhibition of collagenase activity in an in vitro corneal degradation model. | 2018 | Am. J. Vet. Res. | pmid:29688786 |
| Huang YC et al. | Comparison of the therapeutic efficacy of fluoroquinolone and non-fluoroquinolone treatment in patients with Elizabethkingia meningoseptica bacteraemia. | 2018 | Int. J. Antimicrob. Agents | pmid:28668676 |
| Pradier M et al. | Suppressive antibiotic therapy with oral tetracyclines for prosthetic joint infections: a retrospective study of 78 patients. | 2018 | Infection | pmid:29052797 |