Mouse Model
Mouse Model are used in the study 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.' (Wu DC et al., 2002), Mouse Model are used in the study 'Efficacy of a novel tetracycline derivative, glycylcycline, against penicillin-resistant Streptococcus pneumoniae in a mouse model of pneumonia.' (Murakami K et al., 2000), Mouse Model are used in the study 'Neuroprotection of photoreceptors by minocycline in light-induced retinal degeneration.' (Zhang C et al., 2004), Mouse Model are used in the study 'Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism.' (Hayakawa K et al., 2008) and Mouse Model are used in the study 'Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.' (Naura AS et al., 2013).
Experimental Autoimmune Encephalomyelitis
Experimental Autoimmune Encephalomyelitis are used in the study 'Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis.' (Brundula V et al., 2002), Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells.' (Szeto GL et al., 2011), Experimental Autoimmune Encephalomyelitis are used in the study '11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats.' (Converse AK et al., 2011) and Experimental Autoimmune Encephalomyelitis are used in the study 'Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII.' (Nikodemova M et al., 2007).
Disease model
Disease model are used in the study 'Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite.' (Schildknecht S et al., 2011) and Disease model are used in the study 'Hydrophobic ion pairing of a minocycline/Ca(2+)/AOT complex for preparation of drug-loaded PLGA nanoparticles with improved sustained release.' (Holmkvist AD et al., 2016).
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