12-HETE

12-HETE is a lipid of Fatty Acyls (FA) class. 12-HETE is associated with abnormalities such as Endothelial dysfunction, Stable angina, Diabetes and Ischemia. The involved functions are known as Inflammation, Protective Agents, Exocytosis, inhibitors and Signal Transduction. 12-HETE often locates in Endothelium, Integumentary system, Articular system, Tissue fiber and Knee. The related lipids are 9-hydroxy-10,12-octadecadienoic acid, 13-hydroperoxy-9,11-octadecadienoic acid, hydroxy fatty acid and DOPE.

Cross Reference

Introduction

To understand associated biological information of 12-HETE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 12-HETE?

12-HETE is suspected in Endothelial dysfunction, Stable angina, Diabetes, Ischemia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 12-HETE

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Graft Occlusion, Vascular D006083 11 associated lipids
Inflammation D007249 119 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Skin Diseases D012871 9 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Per page 10 20 50 | Total 26

PubChem Associated disorders and diseases

What pathways are associated with 12-HETE

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 12-HETE?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 12-HETE?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 12-HETE?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 12-HETE?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 12-HETE?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 12-HETE

Download all related citations
Per page 10 20 50 100 | Total 801
Authors Title Published Journal PubMed Link
Stadler S et al. Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling. 2017 Cell. Mol. Life Sci. pmid:28013338
Nguyen CH et al. Cancer cell-derived 12(S)-HETE signals via 12-HETE receptor, RHO, ROCK and MLC2 to induce lymph endothelial barrier breaching. 2016 Br. J. Cancer pmid:27362730
Huang YH et al. Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells. 2016 Cells Tissues Organs (Print) pmid:27198524
Xu HZ et al. 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance. 2016 Int J Mol Sci pmid:27164093
Maayah ZH and El-Kadi AO 5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism. 2016 Arch. Toxicol. pmid:25600587
Somjen D et al. Estradiol-17β increases 12- and 15-lipoxygenase (type2) expression and activity and reactive oxygen species in human umbilical vascular smooth muscle cells. 2016 J. Steroid Biochem. Mol. Biol. pmid:27033413
Sun L et al. 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain. 2015 J. Lipid Res. pmid:25605873
Farrar MD et al. A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation. 2015 Am. J. Clin. Nutr. pmid:26178731
Duchez AC et al. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:26106157
Pilkington SM et al. COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn. 2015 Exp. Dermatol. pmid:25939367