Dimethylallyl pyrophosphate

Dimethylallyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Dimethylallyl pyrophosphate is associated with abnormalities such as Consumption-archaic term for TB and Wiskott-Aldrich Syndrome. The involved functions are known as Anabolism, Biochemical Pathway, Oxidation, Process and Chelating Activity [MoA]. Dimethylallyl pyrophosphate often locates in Chloroplasts, Plastids, chloroplast stroma, Cytosol and Cell membrane. The associated genes with Dimethylallyl pyrophosphate are IRF6 wt Allele and ADRBK1 gene. The related lipids are Sterols.

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To understand associated biological information of Dimethylallyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dimethylallyl pyrophosphate?

Dimethylallyl pyrophosphate is suspected in and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dimethylallyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Dimethylallyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Dimethylallyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Dimethylallyl pyrophosphate?

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What functions are associated with Dimethylallyl pyrophosphate?

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What lipids are associated with Dimethylallyl pyrophosphate?

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What genes are associated with Dimethylallyl pyrophosphate?

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What common seen animal models are associated with Dimethylallyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

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Authors Title Published Journal PubMed Link
Maurer-Stroh S and Eisenhaber F Refinement and prediction of protein prenylation motifs. 2005 Genome Biol. pmid:15960807
Sabehi G et al. New insights into metabolic properties of marine bacteria encoding proteorhodopsins. 2005 PLoS Biol. pmid:16008504
Fujisaki S et al. Disruption of the structural gene for farnesyl diphosphate synthase in Escherichia coli. 2005 J. Biochem. pmid:15809342
Mayrhofer S et al. Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves. 2005 Plant Physiol. pmid:16126852
Szkopińska A and Płochocka D Farnesyl diphosphate synthase; regulation of product specificity. 2005 Acta Biochim. Pol. pmid:15827605
Guevara-García A et al. Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-D-erythritol 4-phosphate pathway. 2005 Plant Cell pmid:15659625
Sharkey TD et al. Evolution of the isoprene biosynthetic pathway in kudzu. 2005 Plant Physiol. pmid:15653811
Rosenstiel TN et al. Induction of poplar leaf nitrate reductase: a test of extrachloroplastic control of isoprene emission rate. 2004 Jan-Feb Plant Biol (Stuttg) pmid:15095130
Yamashita S et al. Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae. 2004 Eur. J. Biochem. pmid:15009187
Barkley SJ et al. Proton exchange in type II isopentenyl diphosphate isomerase. 2004 Org. Lett. pmid:15606125
Brandt W et al. A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments. 2004 Chembiochem pmid:14997523
Chau M and Croteau R Molecular cloning and characterization of a cytochrome P450 taxoid 2alpha-hydroxylase involved in Taxol biosynthesis. 2004 Arch. Biochem. Biophys. pmid:15178487
Dhiman RK et al. Identification of a novel class of omega,E,E-farnesyl diphosphate synthase from Mycobacterium tuberculosis. 2004 J. Lipid Res. pmid:15060088
Vitali A et al. Chalcone dimethylallyltransferase from Morus nigra cell cultures. Substrate specificity studies. 2004 FEBS Lett. pmid:14741337
Raschke M et al. A high-performance liquid chromatography method for the analysis of intermediates of the deoxyxylulose phosphate pathway. 2004 Anal. Biochem. pmid:15556562
Mekkriengkrai D et al. Cloning and characterization of farnesyl diphosphate synthase from the rubber-producing mushroom Lactarius chrysorrheus. 2004 Biosci. Biotechnol. Biochem. pmid:15564677
Wille A et al. Sparse graphical Gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana. 2004 Genome Biol. pmid:15535868
Nagaki M et al. Substrate specificities of several prenyl chain elongating enzymes with respect to 4-methyl-4-pentenyl diphosphate. 2004 Biosci. Biotechnol. Biochem. pmid:15502351
Botella-Pavía P et al. Regulation of carotenoid biosynthesis in plants: evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors. 2004 Plant J. pmid:15447646
Wolfertz M et al. Rapid regulation of the methylerythritol 4-phosphate pathway during isoprene synthesis. 2004 Plant Physiol. pmid:15286290
Laupitz R et al. Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. 2004 Eur. J. Biochem. pmid:15206931
Page JE et al. Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing. 2004 Plant Physiol. pmid:15064370
Takagi M et al. Bacillus subtilis ypgA gene is fni, a nonessential gene encoding type 2 isopentenyl diphosphate isomerase. 2004 Biosci. Biotechnol. Biochem. pmid:14745175
Laupitz R et al. Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems. 2004 Chem. Biodivers. pmid:17191914
Thompson K and Rogers MJ Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. 2004 J. Bone Miner. Res. pmid:14969398
Kasahara H et al. Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis. 2004 J. Biol. Chem. pmid:14726522
Burke C et al. Heteromeric geranyl diphosphate synthase from mint: construction of a functional fusion protein and inhibition by bisphosphonate substrate analogs. 2004 Arch. Biochem. Biophys. pmid:14725857
Rohdich F et al. Perspectives in anti-infective drug design. The late steps in the biosynthesis of the universal terpenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. 2004 Bioorg. Chem. pmid:15381396
Loreto F et al. 13C labeling reveals chloroplastic and extrachloroplastic pools of dimethylallyl pyrophosphate and their contribution to isoprene formation. 2004 Plant Physiol. pmid:15286296
Poliquin K et al. Inactivation of sll1556 in Synechocystis strain PCC 6803 impairs isoprenoid biosynthesis from pentose phosphate cycle substrates in vitro. 2004 J. Bacteriol. pmid:15231801
Wang H et al. Conservation of nonpeptide antigen recognition by rhesus monkey V gamma 2V delta 2 T cells. 2003 J. Immunol. pmid:12646635
Wolff M et al. Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein. 2003 FEBS Lett. pmid:12706830
Turek-Etienne TC et al. Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase. 2003 Biochemistry pmid:12667062
Zhao P et al. Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures. 2003 Plant Physiol. pmid:14551337
Chen YH et al. Effects of prenyl pyrophosphates on the binding of PKCgamma with RACK1. 2003 J. Exp. Zoolog. Part A Comp. Exp. Biol. pmid:12506405
Maurer-Stroh S et al. Protein prenyltransferases. 2003 Genome Biol. pmid:12702202
Bick JA and Lange BM Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane. 2003 Arch. Biochem. Biophys. pmid:12831836
Hemmerlin A et al. Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformis. 2003 J. Biol. Chem. pmid:12782626
Carter OA et al. Monoterpene biosynthesis pathway construction in Escherichia coli. 2003 Phytochemistry pmid:12943759
Hemmi H et al. An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase. 2003 Eur. J. Biochem. pmid:12752438
Triolo G et al. Vgamma9/Vdelta2 T lymphocytes in Italian patients with Behçet's disease: evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease. 2003 Arthritis Res. Ther. pmid:12932289
Hirohata S and Kikuchi H Behçet's disease. 2003 Arthritis Res. Ther. pmid:12723980
Neundorf I et al. Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics. 2003 Chembiochem pmid:14613112
Gray CR et al. Studies on the biosynthesis of asperparaline A: origin of the spirosuccinimde ring system. 2003 J. Am. Chem. Soc. pmid:14640629
Kuzuyama T Mevalonate and nonmevalonate pathways for the biosynthesis of isoprene units. 2002 Biosci. Biotechnol. Biochem. pmid:12353619
Okada K et al. Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. 2002 Planta pmid:12029484
Masferrer A et al. Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels. 2002 Plant J. pmid:12000449
Hümbelin M et al. Genetics of isoprenoid biosynthesis in Paracoccus zeaxanthinifaciens. 2002 Gene pmid:12384294
Richard SB et al. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. 2002 J. Biol. Chem. pmid:11786530
Riebeling C et al. The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. 2002 Br. J. Cancer pmid:12177810
Schnee C et al. The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage. 2002 Plant Physiol. pmid:12481088
Abstracts of the Fourth International Symposium on Molecular Insect Science. May 28-June 2, 2002. Tucson, Arizona, USA. 2002 J. Insect Sci. pmid:15455051
Takagi M et al. [Overlooked targets for the development of antibacterial and antimalarial drugs and herbicides: diverse biosynthetic systems for the isoprene units]. 2002 Tanpakushitsu Kakusan Koso pmid:11808197
Mahmoud SS and Croteau RB Strategies for transgenic manipulation of monoterpene biosynthesis in plants. 2002 Trends Plant Sci. pmid:12167332
Ershov YV et al. Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate. 2002 J. Bacteriol. pmid:12193620
Adam P et al. Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12198182
Rosenstiel TN et al. Differential accumulation of dimethylallyl diphosphate in leaves and needles of isoprene- and methylbutenol-emitting and nonemitting species. 2002 Plant Physiol. pmid:12114581
Hoeffler JF et al. Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate. 2002 Biochem. J. pmid:12010124
Little DB and Croteau RB Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase. 2002 Arch. Biochem. Biophys. pmid:12051690
Kakimoto T [Cytokinin]. 2002 Tanpakushitsu Kakusan Koso pmid:12357630
Gossman W and Oldfield E Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens. 2002 J. Med. Chem. pmid:12383012
Altincicek B et al. LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis. 2002 FEBS Lett. pmid:12482608
Liang PH et al. Structure, mechanism and function of prenyltransferases. 2002 Eur. J. Biochem. pmid:12135472
Zeidler J and Lichtenthaler HK Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation. 2001 Planta pmid:11469599
Tholl D et al. Partial purification and characterization of the short-chain prenyltransferases, gernayl diphospate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir). 2001 Arch. Biochem. Biophys. pmid:11368347
Vissa VD and Brennan PJ The genome of Mycobacterium leprae: a minimal mycobacterial gene set. 2001 Genome Biol. pmid:11532219
Campos N et al. Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. 2001 Biochem. J. pmid:11115399
Altincicek B et al. GcpE is involved in the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. 2001 J. Bacteriol. pmid:11274098
Fisher AJ et al. Nonradioactive assay for cellular dimethylallyl diphosphate. 2001 Anal. Biochem. pmid:11355861
Eisenreich W et al. Deoxyxylulose phosphate pathway to terpenoids. 2001 Trends Plant Sci. pmid:11173292
Trapp SC and Croteau RB Genomic organization of plant terpene synthases and molecular evolutionary implications. 2001 Genetics pmid:11404343
Takei K et al. Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana. 2001 J. Biol. Chem. pmid:11313355
Durbecq V et al. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. 2001 EMBO J. pmid:11285217
Phan RM and Poulter CD Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors. 2001 J. Org. Chem. pmid:11578224
Lange BM et al. Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis. 2001 Plant Physiol. pmid:11553758
Wanke M et al. Isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway. 2001 Acta Biochim. Pol. pmid:11833775
Benko AL et al. Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10618371
Dieli F et al. Ligand-specific alphabeta and gammadelta T cell responses in childhood tuberculosis. 2000 J. Infect. Dis. pmid:10608778
Rodríguez-Concepción M et al. Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. 2000 FEBS Lett. pmid:10818234
Ershov Y et al. Isopentenyl diphosphate isomerase deficiency in Synechocystis sp. strain PCC6803. 2000 FEBS Lett. pmid:10818236
Schulbach MC et al. Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis. 2000 J. Biol. Chem. pmid:10816587
Zhang YW et al. Chain length determination of prenyltransferases: both heteromeric subunits of medium-chain (E)-prenyl diphosphate synthase are involved in the product chain length determination. 2000 Biochemistry pmid:11027152
Hirooka K et al. The role of histidine-114 of Ssulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain-length determination. 2000 FEBS Lett. pmid:10984617
Cunningham FX et al. Evidence of a role for LytB in the nonmevalonate pathway of isoprenoid biosynthesis. 2000 J. Bacteriol. pmid:11004185
Miller B et al. Functional involvement of a deoxy-D-xylulose 5-phosphate reductoisomerase gene harboring locus of Synechococcus leopoliensis in isoprenoid biosynthesis. 2000 FEBS Lett. pmid:11007968
Hirooka K et al. Mechanism of product chain length determination for heptaprenyl diphosphate synthase from Bacillus stearothermophilus. 2000 Eur. J. Biochem. pmid:10880976
Tachibana A et al. Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity. 2000 Eur. J. Biochem. pmid:10632701
Keller RK and Fliesler SJ Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. 1999 Biochem. Biophys. Res. Commun. pmid:10600541
Miller B et al. A Synechococcus leopoliensis SAUG 1402-1 operon harboring the 1-deoxyxylulose 5-phosphate synthase gene and two additional open reading frames is functionally involved in the dimethylallyl diphosphate synthesis. 1999 FEBS Lett. pmid:10556522
Leyes AE et al. Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase. 1999 Org. Lett. pmid:10825960
Leung HC et al. Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12. 1997 J. Biol. Chem. pmid:9148919
Moore JA and Poulter CD Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: a binding mechanism for recombinant enzyme. 1997 Biochemistry pmid:9012675
Sireci G et al. Patterns of phosphoantigen stimulation of human Vgamma9/Vdelta2 T cell clones include Th0 cytokines. 1997 Hum. Immunol. pmid:9475336
Koyama T et al. Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. 1996 Biochemistry pmid:8755734
Tanaka Y et al. Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. 1995 Nature pmid:7753173
Koyama T et al. Significance of Phe-220 and Gln-221 in the catalytic mechanism of farnesyl diphosphate synthase of Bacillus stearothermophilus. 1995 Biochem. Biophys. Res. Commun. pmid:7626083
Delourme D et al. Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast. 1994 Plant Mol. Biol. pmid:7858223
Christensen DJ and Poulter CD Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. 1994 Bioorg. Med. Chem. pmid:7858969
Rohmer M et al. Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. 1993 Biochem. J. pmid:8240251
Light DR and Dennis MS Purification of a prenyltransferase that elongates cis-polyisoprene rubber from the latex of Hevea brasiliensis. 1989 J. Biol. Chem. pmid:2808388