Isopentenyl pyrophosphate

Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.

Cross Reference

Introduction

To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Isopentenyl pyrophosphate?

Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Isopentenyl pyrophosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Isopentenyl pyrophosphate?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Isopentenyl pyrophosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Isopentenyl pyrophosphate?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Isopentenyl pyrophosphate

Download all related citations
Per page 10 20 50 100 | Total 1004
Authors Title Published Journal PubMed Link
Bang S et al. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. 2011 Pain pmid:21353389
Liu T and Khosla C Chemistry. A balancing act for Taxol precursor pathways in E. coli. 2010 Science pmid:20929799
Ajikumar PK et al. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. 2010 Science pmid:20929806
Lee M et al. Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG. 2010 J. Mol. Biol. pmid:20932974
Srivastava NK and Srivastava AK Influence of Some Heavy Metals on Growth, Alkaloid Content and Composition in Catharanthus roseus L. 2010 Indian J Pharm Sci pmid:21969751
Morrone D et al. Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. 2010 Appl. Microbiol. Biotechnol. pmid:19777230
Li Y et al. EST analysis reveals putative genes involved in glycyrrhizin biosynthesis. 2010 BMC Genomics pmid:20423525
Urzúa U et al. Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis. 2010 BMC Genomics pmid:21210965
Piepho M et al. Simultaneous effects of light intensity and phosphorus supply on the sterol content of phytoplankton. 2010 PLoS ONE pmid:21209879
Mongan MA et al. A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity. 2010 PLoS ONE pmid:21203578
Tritsch D et al. Plant isoprenoid biosynthesis via the MEP pathway: in vivo IPP/DMAPP ratio produced by (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase in tobacco BY-2 cell cultures. 2010 FEBS Lett. pmid:19903472
Holen I and Coleman RE Anti-tumour activity of bisphosphonates in preclinical models of breast cancer. 2010 Breast Cancer Res. pmid:21176176
Kim J et al. Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis. 2010 Mol. Syst. Biol. pmid:21119630
Wang C et al. Farnesol production from Escherichia coli by harnessing the exogenous mevalonate pathway. 2010 Biotechnol. Bioeng. pmid:20552672
Sharma NK et al. Type II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analogues. 2010 Biochemistry pmid:20560533
Arsenault PR et al. Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua. 2010 Plant Physiol. pmid:20724645
Leonard E et al. Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20643967
Domagalska MA et al. Genetic analyses of interactions among gibberellin, abscisic acid, and brassinosteroids in the control of flowering time in Arabidopsis thaliana. 2010 PLoS ONE pmid:21103336
Voskens CJ et al. Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity. 2010 J. Exp. Clin. Cancer Res. pmid:20937115
Plata G et al. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. 2010 Mol. Syst. Biol. pmid:20823846
Lim MJ et al. Acute effects of intravenous administration of pamidronate in patients with osteoporosis. 2010 J. Korean Med. Sci. pmid:20808669
Pazianas M et al. Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis. 2010 Ther Clin Risk Manag pmid:20668715
Zhang F et al. An L1 box binding protein, GbML1, interacts with GbMYB25 to control cotton fibre development. 2010 J. Exp. Bot. pmid:20667961
Maniar A et al. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. 2010 Blood pmid:20519625
Mookerjee-Basu J et al. F1-adenosine triphosphatase displays properties characteristic of an antigen presentation molecule for Vgamma9Vdelta2 T cells. 2010 J. Immunol. pmid:20483757
Kumari U and Heese K Cardiovascular dementia - a different perspective. 2010 Open Biochem J pmid:20448820
Sun C et al. De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. 2010 BMC Genomics pmid:20416102
Urban EM et al. Repertoire development and the control of cytotoxic/effector function in human gammadelta T cells. 2010 Clin. Dev. Immunol. pmid:20396597
Pan IL et al. Functional diversification of AGAMOUS lineage genes in regulating tomato flower and fruit development. 2010 J. Exp. Bot. pmid:20335407
Yasuor H et al. Differential oxidative metabolism and 5-ketoclomazone accumulation are involved in Echinochloa phyllopogon resistance to clomazone. 2010 Plant Physiol. pmid:20207709
Hokugo A et al. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. 2010 J. Bone Miner. Res. pmid:20200938
Yao S et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. 2010 PLoS Pathog. pmid:20195465
Schmidt T et al. Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz. 2010 BMC Biochem. pmid:20170509
Monnet C et al. The arthrobacter arilaitensis Re117 genome sequence reveals its genetic adaptation to the surface of cheese. 2010 PLoS ONE pmid:21124797
Rios-Estepa R et al. Mathematical modeling-guided evaluation of biochemical, developmental, environmental, and genotypic determinants of essential oil composition and yield in peppermint leaves. 2010 Plant Physiol. pmid:20147490
Cavalier-Smith T Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution. 2010 Biol. Direct pmid:20132544
Lambert C et al. The first bite--profiling the predatosome in the bacterial pathogen Bdellovibrio. 2010 PLoS ONE pmid:20062540
Dalle Carbonare L et al. Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management. 2010 Drug Healthc Patient Saf pmid:21701624
Yamamizo C et al. Carotenoid composition and carotenogenic gene expression during Ipomoea petal development. 2010 J. Exp. Bot. pmid:19933319
Mialoundama AS et al. Characterization of plant carotenoid cyclases as members of the flavoprotein family functioning with no net redox change. 2010 Plant Physiol. pmid:20460582
Trost E et al. Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion. 2010 BMC Genomics pmid:20137072
Lim L and McFadden GI The evolution, metabolism and functions of the apicoplast. 2010 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:20124342
Takaichi S et al. Carotenoids of Gemmatimonas aurantiaca (Gemmatimonadetes): identification of a novel carotenoid, deoxyoscillol 2-rhamnoside, and proposed biosynthetic pathway of oscillol 2,2'-dirhamnoside. 2010 Microbiology (Reading, Engl.) pmid:19959572
González-Candelas L et al. A transcriptomic approach highlights induction of secondary metabolism in citrus fruit in response to Penicillium digitatum infection. 2010 BMC Plant Biol. pmid:20807411
Guella G et al. Structures, biological activities and phylogenetic relationships of terpenoids from marine ciliates of the genus Euplotes. 2010 Mar Drugs pmid:20714425
Behnke K et al. RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis. 2010 Plant Mol. Biol. pmid:20526857
Targett-Adams P et al. Lipid metabolism and HCV infection. 2010 Viruses pmid:21994676
Lee LV et al. Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase. 2010 Biochemistry pmid:20476728
Klawitter J et al. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. 2010 Breast Cancer Res. pmid:20205716
De Schutter JW et al. Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase. 2010 Bioorg. Med. Chem. Lett. pmid:20801032
Lu YP et al. Mechanism of cis-prenyltransferase reaction probed by substrate analogues. 2010 Biochem. Biophys. Res. Commun. pmid:20828539
Kiran U et al. Structural and functional characterization of HMG-COA reductase from Artemisia annua. 2010 Bioinformation pmid:21364776
Dunne MR et al. Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells. 2010 Mediators Inflamm. pmid:21403900
Tisch D and Schmoll M Light regulation of metabolic pathways in fungi. 2010 Appl. Microbiol. Biotechnol. pmid:19915832
Tchaparian E et al. Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways. 2010 Biochem. J. pmid:20491655
Dolzhenko Y et al. UV-B modulates the interplay between terpenoids and flavonoids in peppermint (Mentha x piperita L.). 2010 J. Photochem. Photobiol. B, Biol. pmid:20627615
Gresh N et al. Analysis of the interactions taking place in the recognition site of a bimetallic Mg(II)-Zn(II) enzyme, isopentenyl diphosphate isomerase. a parallel quantum-chemical and polarizable molecular mechanics study. 2010 J Phys Chem B pmid:20329783
Dellas N and Noel JP Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. 2010 ACS Chem. Biol. pmid:20392112
Chen M and Poulter CD Characterization of thermophilic archaeal isopentenyl phosphate kinases. 2010 Biochemistry pmid:19928876
Räikkönen J et al. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells. 2010 Biochem. Pharmacol. pmid:19819230
Mitrofan LM et al. Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells. 2010 J. Biol. Chem. pmid:19875454
Hasunuma T et al. Metabolic engineering by plastid transformation as a strategy to modulate isoprenoid yield in plants. 2010 Methods Mol. Biol. pmid:20552454
Huang CH et al. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. 2010 Proteins pmid:19876942
Meraviglia S et al. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. 2010 Clin. Exp. Immunol. pmid:20491785
Singh RS et al. Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston]. 2010 BMC Mol. Biol. pmid:21092138
Yadav VR et al. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. 2010 Toxins (Basel) pmid:22069560
Cabillic F et al. Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients. 2010 Cancer Immunol. Immunother. pmid:20582413
Ganjewala D and Luthra R Essential oil biosynthesis and regulation in the genus Cymbopogon. 2010 Nat Prod Commun pmid:20184044
Rojruthai P et al. In vitro synthesis of high molecular weight rubber by Hevea small rubber particles. 2010 J. Biosci. Bioeng. pmid:20129092
Chang TH et al. Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation. 2010 Plant Cell pmid:20139160
Goto T et al. Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism. 2010 PPAR Res pmid:20613991
Diamond DL et al. Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. 2010 PLoS Pathog. pmid:20062526
Joseph SJ et al. The Alveolate Perkinsus marinus: biological insights from EST gene discovery. 2010 BMC Genomics pmid:20374649
Nickerson ML et al. UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy. 2010 PLoS ONE pmid:20505825
Huthmacher C et al. Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. 2010 BMC Syst Biol pmid:20807400
Singkaravanit S et al. Geranylgeranyl diphosphate synthase genes in entomopathogenic fungi. 2010 Appl. Microbiol. Biotechnol. pmid:19690851
Emanuelli F et al. A candidate gene association study on muscat flavor in grapevine (Vitis vinifera L.). 2010 BMC Plant Biol. pmid:21062440
Luo H et al. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. 2010 BMC Plant Biol. pmid:20854695
Kabelitz D Human γδ T lymphocytes for immunotherapeutic strategies against cancer. 2010 F1000 Med Rep pmid:20948839
Kishi-Kaboshi M et al. A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis. 2010 Plant J. pmid:20525005
Costa GG et al. Transcriptome analysis of the oil-rich seed of the bioenergy crop Jatropha curcas L. 2010 BMC Genomics pmid:20691070
Thibodeaux CJ et al. Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. 2010 J. Am. Chem. Soc. pmid:20593767
Ohara K et al. Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa. 2010 J. Exp. Bot. pmid:20421194
Mabanglo MF et al. X-ray structures of isopentenyl phosphate kinase. 2010 ACS Chem. Biol. pmid:20402538
Aw T et al. Functional genomics of mountain pine beetle (Dendroctonus ponderosae) midguts and fat bodies. 2010 BMC Genomics pmid:20353591
Kalinowska-Tłuścik J et al. A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure. 2010 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:20208151
Narayanasamy P et al. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium tuberculosis IspF. 2010 Chem. Biol. pmid:20189102
Ibrahim MA et al. Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. 2010 J. Exp. Bot. pmid:20181662
Bang S et al. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. 2010 Br. J. Pharmacol. pmid:20880407
Schilmiller AL et al. Studies of a biochemical factory: tomato trichome deep expressed sequence tag sequencing and proteomics. 2010 Plant Physiol. pmid:20431087
Baikar S and Malpathak N Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs. 2010 Pharmacogn Rev pmid:22228937
Cann AF and Liao JC Pentanol isomer synthesis in engineered microorganisms. 2010 Appl. Microbiol. Biotechnol. pmid:19859707
Plaimas K et al. Identifying essential genes in bacterial metabolic networks with machine learning methods. 2010 BMC Syst Biol pmid:20438628
Dellomonaco C et al. The path to next generation biofuels: successes and challenges in the era of synthetic biology. 2010 Microb. Cell Fact. pmid:20089184
Du H et al. Characterization of the beta-carotene hydroxylase gene DSM2 conferring drought and oxidative stress resistance by increasing xanthophylls and abscisic acid synthesis in rice. 2010 Plant Physiol. pmid:20852032
Kudoh T et al. Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae. 2010 Bioorg. Med. Chem. pmid:20056424
Hawari AH and Mohamed-Hussein ZA Simulation of a Petri net-based model of the terpenoid biosynthesis pathway. 2010 BMC Bioinformatics pmid:20144236
Brannian J et al. Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study. 2009 J Ovarian Res pmid:19650929
Iriti M and Faoro F Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. 2009 Int J Mol Sci pmid:20111684
Kroll J et al. Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology. 2009 Metab. Eng. pmid:19558962