| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
Total
1
Isopentenyl pyrophosphate
Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
Cross Reference
Introduction
To understand associated biological information of Isopentenyl pyrophosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Isopentenyl pyrophosphate?
Isopentenyl pyrophosphate is suspected in Tuberculosis, NAVAJO NEUROHEPATOPATHY, Cryptosporidiosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Isopentenyl pyrophosphate
PubChem Associated disorders and diseases
What pathways are associated with Isopentenyl pyrophosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Isopentenyl pyrophosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Isopentenyl pyrophosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Isopentenyl pyrophosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Isopentenyl pyrophosphate?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Isopentenyl pyrophosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Touzé T et al. | Periplasmic phosphorylation of lipid A is linked to the synthesis of undecaprenyl phosphate. | 2008 | Mol. Microbiol. | pmid:18047581 |
| Ro DK et al. | Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. | 2008 | BMC Biotechnol. | pmid:18983675 |
| Kervizic G and Corcos L | Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. | 2008 | BMC Syst Biol | pmid:19025648 |
| Jung KH et al. | Identification and functional analysis of light-responsive unique genes and gene family members in rice. | 2008 | PLoS Genet. | pmid:18725934 |
| Ruangweerayut R et al. | Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria. | 2008 | Malar. J. | pmid:18973702 |
| Ferrarini M et al. | NF-kappa B modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gamma delta lymphocytes. | 2008 | J. Immunol. | pmid:18941174 |
| Derhovanessian E et al. | Immunity, ageing and cancer. | 2008 | Immun Ageing | pmid:18816370 |
| Noike M et al. | Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18790692 |
| Soundararajan R et al. | Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. | 2008 | J. Biol. Chem. | pmid:18032389 |
| Argout X et al. | Towards the understanding of the cocoa transcriptome: Production and analysis of an exhaustive dataset of ESTs of Theobroma cacao L. generated from various tissues and under various conditions. | 2008 | BMC Genomics | pmid:18973681 |
| Jassbi AR et al. | Silencing geranylgeranyl diphosphate synthase in Nicotiana attenuata dramatically impairs resistance to tobacco hornworm. | 2008 | Plant Physiol. | pmid:17965175 |
| Schmidt A and Gershenzon J | Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies). | 2008 | Phytochemistry | pmid:17673268 |
| AlcaÃno J et al. | Cloning of the cytochrome p450 reductase (crtR) gene and its involvement in the astaxanthin biosynthesis of Xanthophyllomyces dendrorhous. | 2008 | BMC Microbiol. | pmid:18837978 |
| Arimura G et al. | Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling. | 2008 | Planta | pmid:17924138 |
| Mönkkönen H et al. | Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. | 2008 | Anticancer Drugs | pmid:18454049 |
| Alexander AA et al. | Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. | 2008 | Clin. Cancer Res. | pmid:18594005 |
| Catusse J et al. | Proteome-wide characterization of sugarbeet seed vigor and its tissue specific expression. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18635686 |
| Yoon SH et al. | Increased beta-carotene production in recombinant Escherichia coli harboring an engineered isoprenoid precursor pathway with mevalonate addition. | 2007 May-Jun | Biotechnol. Prog. | pmid:17500531 |
| Quinzii CM et al. | Human coenzyme Q10 deficiency. | 2007 Apr-May | Neurochem. Res. | pmid:17094036 |
| Bock O et al. | Common musculoskeletal adverse effects of oral treatment with once weekly alendronate and risedronate in patients with osteoporosis and ways for their prevention. | 2007 Apr-Jun | J Musculoskelet Neuronal Interact | pmid:17627083 |
| Moe M et al. | Gene expression profiles in testis of pigs with extreme high and low levels of androstenone. | 2007 | BMC Genomics | pmid:17988377 |
| Yoon SH et al. | Engineering the lycopene synthetic pathway in E. coli by comparison of the carotenoid genes of Pantoea agglomerans and Pantoea ananatis. | 2007 | Appl. Microbiol. Biotechnol. | pmid:17115209 |
| Das A et al. | An update on microbial carotenoid production: application of recent metabolic engineering tools. | 2007 | Appl. Microbiol. Biotechnol. | pmid:17912511 |
| Walsh CT | Revealing coupling patterns in isoprenoid alkylation biocatalysis. | 2007 | ACS Chem. Biol. | pmid:17518430 |
| Amslinger S et al. | Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate. | 2007 | Immunobiology | pmid:17270709 |
| Christianson DW | Chemistry. Roots of biosynthetic diversity. | 2007 | Science | pmid:17412944 |
| Matsumura Y et al. | The carboxyl-terminal region of the geranylgeranyl diphosphate synthase is indispensable for the stabilization of the region involved in substrate binding and catalysis. | 2007 | J. Biochem. | pmid:17846065 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Nagaki M et al. | Substrate specificities of wild and mutated farnesyl diphosphate synthases from Bacillus stearothermophilus with artificial substrates. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17617711 |
| Mi J et al. | Age-related subproteomic analysis of mouse liver and kidney peroxisomes. | 2007 | Proteome Sci | pmid:18042274 |
| Hoshino T and Eguchi T | Functional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928693 |
| Anisimova M et al. | Phylogenomic analysis of natural selection pressure in Streptococcus genomes. | 2007 | BMC Evol. Biol. | pmid:17760998 |
| Sangar V et al. | Quantitative sequence-function relationships in proteins based on gene ontology. | 2007 | BMC Bioinformatics | pmid:17686158 |
| Lodato P et al. | Expression of the carotenoid biosynthesis genes in Xanthophyllomyces dendrorhous. | 2007 | Biol. Res. | pmid:17657357 |
| Huang J and Gogarten JP | Did an ancient chlamydial endosymbiosis facilitate the establishment of primary plastids? | 2007 | Genome Biol. | pmid:17547748 |
| Murphy DJ and Brown JR | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. | 2007 | BMC Infect. Dis. | pmid:17655757 |
| Na-Bangchang K et al. | Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria. | 2007 | Malar. J. | pmid:17531088 |
| Clizbe DB et al. | IDI2, a second isopentenyl diphosphate isomerase in mammals. | 2007 | J. Biol. Chem. | pmid:17202134 |
| Bulashevska S et al. | New insights into the genetic regulation of Plasmodium falciparum obtained by Bayesian modeling. | 2007 | Gene Regul Syst Bio | pmid:19936084 |
| Lopes AA et al. | Biosynthetic origins of the isoprene units of gaudichaudianic acid in Piper gaudichaudianum (Piperaceae). | 2007 | Phytochemistry | pmid:17574633 |
| Kulaber A et al. | Pro-inflammatory cellular immune response in Behçet's disease. | 2007 | Rheumatol. Int. | pmid:17549482 |
| Sgraja T et al. | Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. | 2007 | BMC Struct. Biol. | pmid:17397541 |
| Wang YD et al. | Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. | 2007 | Cell Biol. Int. | pmid:17521928 |
| Puan KJ et al. | Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells. | 2007 | Int. Immunol. | pmid:17446209 |
| Henriksson LM et al. | Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. | 2007 | J. Biol. Chem. | pmid:17491006 |
| Rothman SC et al. | Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin species. | 2007 | Biochemistry | pmid:17428035 |
| Julsing MK et al. | Functional analysis of genes involved in the biosynthesis of isoprene in Bacillus subtilis. | 2007 | Appl. Microbiol. Biotechnol. | pmid:17458547 |
| Glickman JF and Schmid A | Farnesyl pyrophosphate synthase: real-time kinetics and inhibition by nitrogen-containing bisphosphonates in a scintillation assay. | 2007 | Assay Drug Dev Technol | pmid:17477829 |
| Saito K et al. | Short-chain prenyl diphosphate synthase that condenses isopentenyl diphosphate with dimethylallyl diphosphate in ispA null Escherichia coli strain lacking farnesyl diphosphate synthase. | 2007 | J. Biosci. Bioeng. | pmid:17630132 |
| Klein-Marcuschamer D et al. | Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. | 2007 | Trends Biotechnol. | pmid:17681626 |
| Mönkkönen H et al. | Zoledronic acid-induced IPP/ApppI production in vivo. | 2007 | Life Sci. | pmid:17850825 |
| Grimplet J et al. | Tissue-specific mRNA expression profiling in grape berry tissues. | 2007 | BMC Genomics | pmid:17584945 |
| Towler MJ and Weathers PJ | Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. | 2007 | Plant Cell Rep. | pmid:17710406 |
| Withers ST et al. | Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity. | 2007 | Appl. Environ. Microbiol. | pmid:17693564 |
| Wilcox CB et al. | Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. | 2007 | BMC Cancer | pmid:18070364 |
| Velasco R et al. | A high quality draft consensus sequence of the genome of a heterozygous grapevine variety. | 2007 | PLoS ONE | pmid:18094749 |
| Buetow L et al. | The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery. | 2007 | BMC Struct. Biol. | pmid:17956607 |
| Cassera MB et al. | Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum. | 2007 | Mem. Inst. Oswaldo Cruz | pmid:17568945 |
| Schirra F et al. | Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland. | 2007 | Curr. Eye Res. | pmid:17514523 |
| Hebbeler AM et al. | Individual Vgamma2-Jgamma1.2+ T cells respond to both isopentenyl pyrophosphate and Daudi cell stimulation: generating tumor effectors with low molecular weight phosphoantigens. | 2007 | Cancer Immunol. Immunother. | pmid:17131122 |
| Byres E et al. | Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. | 2007 | J. Mol. Biol. | pmid:17583736 |
| Kinjoh T et al. | Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. | 2007 | Insect Biochem. Mol. Biol. | pmid:17628279 |
| Scott KM et al. | The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2. | 2006 | PLoS Biol. | pmid:17105352 |
| Kloer DP et al. | Structure and reaction geometry of geranylgeranyl diphosphate synthase from Sinapis alba. | 2006 | Biochemistry | pmid:17176041 |
| Gibon Y et al. | Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes. | 2006 | Genome Biol. | pmid:16916443 |
| Thulasiram HV and Poulter CD | Farnesyl diphosphate synthase: the art of compromise between substrate selectivity and stereoselectivity. | 2006 | J. Am. Chem. Soc. | pmid:17147392 |
| Forster AC and Church GM | Towards synthesis of a minimal cell. | 2006 | Mol. Syst. Biol. | pmid:16924266 |
| Depasquale I and Wheatley DN | Action of Lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines. | 2006 | Cancer Cell Int. | pmid:16573823 |
| Chang TH et al. | Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. | 2006 | J. Biol. Chem. | pmid:16554305 |
| Kharel Y et al. | Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases. | 2006 | FEBS J. | pmid:16420487 |
| Goffinet M et al. | Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells. | 2006 | BMC Cancer | pmid:16539721 |
| Houde M et al. | Wheat EST resources for functional genomics of abiotic stress. | 2006 | BMC Genomics | pmid:16772040 |
| Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |
| Kim SJ et al. | Amplification of 1-deoxy-D-xyluose 5-phosphate (DXP) synthase level increases coenzyme Q10 production in recombinant Escherichia coli. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16532312 |
| Workalemahu G et al. | Expression of metalloproteinase-7 (matrilysin) in human blood and bronchoalveolar gamma/delta T-lymphocytes. Selective upregulation by the soluble non-peptidic mycobacterial phosphoantigen (isopentenyl pyrophosphate). | 2006 | J. Cell. Physiol. | pmid:16250011 |
| Zahiri HS et al. | Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. | 2006 | Metab. Eng. | pmid:16815062 |
| Caccamo N et al. | Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. | 2006 | J. Leukoc. Biol. | pmid:16461739 |
| Scholte AA and Vederas JC | Incorporation of deuterium-labelled analogs of isopentenyl diphosphate for the elucidation of the stereochemistry of rubber biosynthesis. | 2006 | Org. Biomol. Chem. | pmid:16467948 |
| Fischbach MA and Walsh CT | Biochemistry. Directing biosynthesis. | 2006 | Science | pmid:17068249 |
| Theivagt AE et al. | Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity. | 2006 | Biochemistry | pmid:17128979 |
| Zahiri HS et al. | Biochemical characterization of the decaprenyl diphosphate synthase of Rhodobacter sphaeroides for coenzyme Q10 production. | 2006 | Appl. Microbiol. Biotechnol. | pmid:16896603 |
| Muñoz-Bertomeu J et al. | Up-regulation of 1-deoxy-D-xylulose-5-phosphate synthase enhances production of essential oils in transgenic spike lavender. | 2006 | Plant Physiol. | pmid:16980564 |
| Herzig C et al. | Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells. | 2006 | Immunogenetics | pmid:16541255 |
| Cervantes-Cervantes M et al. | Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity. | 2006 | Plant Physiol. | pmid:16581875 |
| Yoon SH et al. | Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. | 2006 | Biotechnol. Bioeng. | pmid:16547999 |
| Maurice T et al. | Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection. | 2006 | Pharmacol. Biochem. Behav. | pmid:16945406 |
| Grochowski LL et al. | Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | 2006 | J. Bacteriol. | pmid:16621811 |
| Kavanagh KL et al. | The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. | 2006 | J. Biol. Chem. | pmid:16698791 |
| Hsiao YY et al. | Comparison of transcripts in Phalaenopsis bellina and Phalaenopsis equestris (Orchidaceae) flowers to deduce monoterpene biosynthesis pathway. | 2006 | BMC Plant Biol. | pmid:16836766 |
| Thompson K et al. | Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway. | 2006 | Blood | pmid:16179378 |
| Vadali RV et al. | Enhanced lycopene productivity by manipulation of carbon flow to isopentenyl diphosphate in Escherichia coli. | 2005 Sep-Oct | Biotechnol. Prog. | pmid:16209562 |
| da Costa BM et al. | Regulation of rubber biosynthetic rate and molecular weight in Hevea brasiliensis by metal cofactor. | 2005 Jan-Feb | Biomacromolecules | pmid:15638531 |
| Re F et al. | Skewed representation of functionally distinct populations of Vgamma9Vdelta2 T lymphocytes in aging. | 2005 Jan-Feb | Exp. Gerontol. | pmid:15664733 |
| Baker SK and Tarnopolsky MA | Statin-associated neuromyotoxicity. | 2005 | Drugs Today | pmid:16034491 |
| Rohdich F et al. | Isoprenoid biosynthetic pathways as anti-infective drug targets. | 2005 | Biochem. Soc. Trans. | pmid:16042599 |
| Corvaisier M et al. | V gamma 9V delta 2 T cell response to colon carcinoma cells. | 2005 | J. Immunol. | pmid:16210656 |
| Sicard H et al. | In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. | 2005 | J. Immunol. | pmid:16210655 |
| Gil MJ et al. | The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway. | 2005 | Plant J. | pmid:16167903 |
| Casetti R et al. | Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. | 2005 | J. Immunol. | pmid:16034098 |
| Flügge UI and Gao W | Transport of isoprenoid intermediates across chloroplast envelope membranes. | 2005 | Plant Biol (Stuttg) | pmid:15666208 |