| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Brain Neoplasms | D001932 | 15 associated lipids |
(-)-Perillyl alcohol
(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol
PubChem Associated disorders and diseases
What pathways are associated with (-)-Perillyl alcohol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with (-)-Perillyl alcohol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with (-)-Perillyl alcohol?
There are no associated biomedical information in the current reference collection.
What genes are associated with (-)-Perillyl alcohol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with (-)-Perillyl alcohol?
Transgenic Model
Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with (-)-Perillyl alcohol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ansari MA et al. | Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. | 2016 | PLoS ONE | pmid:27627759 |
| Chen TC et al. | Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. | 2016 | Int J Mol Sci | pmid:27598140 |
| Song X et al. | Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. | 2016 | Sci Rep | pmid:26949038 |
| Andrade LN et al. | In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. | 2016 | Int J Mol Sci | pmid:26742032 |
| Xie L et al. | Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. | 2016 | Oncotarget | pmid:26625208 |
| Garcia DG et al. | Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. | 2015 | Mol. Cancer | pmid:25976744 |
| d'Alessio PA et al. | Skin repair properties of d-Limonene and perillyl alcohol in murine models. | 2014 | Antiinflamm Antiallergy Agents Med Chem | pmid:24160248 |
| Wróblewska A | The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. | 2014 | Molecules | pmid:25460313 |
| Sarkar S et al. | Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. | 2014 | Curr. Mol. Med. | pmid:24236457 |
| Imamura M et al. | Perillyl alcohol suppresses antigen-induced immune responses in the lung. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24309112 |
| D'Alincourt Salazar M et al. | Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo. | 2014 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:24257817 |
| Nandurkar NS et al. | The identification of perillyl alcohol glycosides with improved antiproliferative activity. | 2014 | J. Med. Chem. | pmid:25121720 |
| Hui Z et al. | Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. | 2014 | Molecules | pmid:24858099 |
| Chen TC et al. | A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. | 2014 | Mol. Cancer Ther. | pmid:24623736 |
| Alonso-Gutierrez J et al. | Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. | 2013 | Metab. Eng. | pmid:23727191 |
| Lefranc F et al. | 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. | 2013 | Eur J Med Chem | pmid:23474907 |
| Sundin T et al. | Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. | 2013 | Mol. Cell. Biochem. | pmid:23283642 |
| Koyama M et al. | Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. | 2013 | Oncol. Rep. | pmid:23233050 |
| Sultana S et al. | Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. | 2013 | Hum Exp Toxicol | pmid:23536516 |
| Sundin T et al. | eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. | 2013 | Exp. Cell Res. | pmid:23747720 |
| Silva MM et al. | Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. | 2013 | Genet. Mol. Res. | pmid:23765968 |
| DA Fonseca CO et al. | Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. | 2013 | Anticancer Res. | pmid:24324108 |
| Cornelissen S et al. | Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL. | 2013 | Biotechnol. Bioeng. | pmid:23239244 |
| Farazuddin M et al. | Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. | 2012 | Int J Nanomedicine | pmid:22275821 |
| Jung HJ et al. | Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. | 2012 | Blood | pmid:22294726 |
| Cho HY et al. | Perillyl alcohol for the treatment of temozolomide-resistant gliomas. | 2012 | Mol. Cancer Ther. | pmid:22933703 |
| da Silveira Fd et al. | Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22481252 |
| Sundin T et al. | The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. | 2012 | Biochimie | pmid:22902867 |
| Duelund L et al. | Influence of the active compounds of Perilla frutescens leaves on lipid membranes. | 2012 | J. Nat. Prod. | pmid:22272932 |
| Bicas JL et al. | Evaluation of the antioxidant and antiproliferative potential of bioflavors. | 2011 | Food Chem. Toxicol. | pmid:21540069 |
| Khan AQ et al. | Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. | 2011 | Toxicology | pmid:20923693 |
| de Saldanha da Gama Fischer J et al. | Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. | 2011 | J. Proteome Res. | pmid:20806975 |
| da Fonseca CO et al. | Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. | 2011 | J. Cancer Res. Clin. Oncol. | pmid:20401670 |
| Prado R et al. | Nonmelanoma skin cancer chemoprevention. | 2011 | Dermatol Surg | pmid:21895847 |
| Kiran I | Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. | 2011 | Nat Prod Commun | pmid:22312710 |
| Cornelissen S et al. | Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21559976 |
| Seifert A et al. | An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. | 2011 | Chembiochem | pmid:21591046 |
| Garcia DG et al. | The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. | 2010 | Mol. Cell. Biochem. | pmid:20689980 |
| Stratton SP et al. | A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. | 2010 | Cancer Prev Res (Phila) | pmid:20103724 |
| Clifford JL and DiGiovanni J | The promise of natural products for blocking early events in skin carcinogenesis. | 2010 | Cancer Prev Res (Phila) | pmid:20103730 |
| Fischer Jde S et al. | Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. | 2010 | J Proteomics | pmid:20083244 |
| Yeruva L et al. | Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. | 2010 | Anticancer Drugs | pmid:19820395 |
| Chaudhary SC et al. | Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. | 2009 | Chem. Biol. Interact. | pmid:19161993 |
| Da Fonseca CO et al. | Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. | 2009 | Invest New Drugs | pmid:19139816 |
| Magkouta S et al. | Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. | 2009 | Nutr Cancer | pmid:19838938 |
| Zhou W et al. | Components of lemon essential oil attenuate dementia induced by scopolamine. | 2009 | Nutr Neurosci | pmid:19356307 |
| Kim D and Ortiz de Montellano PR | Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. | 2009 | Biotechnol. Lett. | pmid:19458919 |
| da Fonseca CO et al. | Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. | 2008 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:18726148 |
| Bailey HH et al. | Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer. | 2008 | Cancer Chemother. Pharmacol. | pmid:17885756 |
| Lebedeva IV et al. | Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol. | 2008 | Cancer Res. | pmid:18768668 |