(-)-Perillyl alcohol

(-)-perillyl alcohol is a lipid of Prenol Lipids (PR) class. The involved functions are known as Cell Cycle Progression, Cell Cycle, Cell Proliferation, Apoptosis and Isoprenylation. (-)-perillyl alcohol often locates in Cytoplasm, Membrane and Plasma membrane. The associated genes with (-)-Perillyl alcohol are JUN gene, Candidate Disease Gene, IL24 gene, BCL2L1 gene and CFB gene. The related experimental models are Transgenic Model.

Cross Reference


To understand associated biological information of (-)-Perillyl alcohol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (-)-Perillyl alcohol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Brain Neoplasms D001932 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with (-)-Perillyl alcohol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with (-)-Perillyl alcohol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with (-)-Perillyl alcohol?

There are no associated biomedical information in the current reference collection.

What genes are associated with (-)-Perillyl alcohol?

Related references are published most in these journals:

Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with (-)-Perillyl alcohol?

Transgenic Model

Transgenic Model are used in the study 'A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.' (Stratton SP et al., 2010).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with (-)-Perillyl alcohol

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Per page 10 20 50 100 | Total 165
Authors Title Published Journal PubMed Link
Ansari MA et al. Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. 2016 PLoS ONE pmid:27627759
Chen TC et al. Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. 2016 Int J Mol Sci pmid:27598140
Song X et al. Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. 2016 Sci Rep pmid:26949038
Andrade LN et al. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. 2016 Int J Mol Sci pmid:26742032
Xie L et al. Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. 2016 Oncotarget pmid:26625208
Garcia DG et al. Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol. 2015 Mol. Cancer pmid:25976744
d'Alessio PA et al. Skin repair properties of d-Limonene and perillyl alcohol in murine models. 2014 Antiinflamm Antiallergy Agents Med Chem pmid:24160248
Wróblewska A The epoxidation of limonene over the TS-1 and Ti-SBA-15 catalysts. 2014 Molecules pmid:25460313
Sarkar S et al. Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus. 2014 Curr. Mol. Med. pmid:24236457
Imamura M et al. Perillyl alcohol suppresses antigen-induced immune responses in the lung. 2014 Biochem. Biophys. Res. Commun. pmid:24309112
D'Alincourt Salazar M et al. Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo. 2014 Arch. Immunol. Ther. Exp. (Warsz.) pmid:24257817
Nandurkar NS et al. The identification of perillyl alcohol glycosides with improved antiproliferative activity. 2014 J. Med. Chem. pmid:25121720
Hui Z et al. Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives. 2014 Molecules pmid:24858099
Chen TC et al. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. 2014 Mol. Cancer Ther. pmid:24623736
Alonso-Gutierrez J et al. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. 2013 Metab. Eng. pmid:23727191
Lefranc F et al. 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. 2013 Eur J Med Chem pmid:23474907
Sundin T et al. Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. 2013 Mol. Cell. Biochem. pmid:23283642
Koyama M et al. Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction. 2013 Oncol. Rep. pmid:23233050
Sultana S et al. Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation. 2013 Hum Exp Toxicol pmid:23536516
Sundin T et al. eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. 2013 Exp. Cell Res. pmid:23747720
Silva MM et al. Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. 2013 Genet. Mol. Res. pmid:23765968
DA Fonseca CO et al. Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation. 2013 Anticancer Res. pmid:24324108
Cornelissen S et al. Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL. 2013 Biotechnol. Bioeng. pmid:23239244
Farazuddin M et al. Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles. 2012 Int J Nanomedicine pmid:22275821
Jung HJ et al. Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities. 2012 Blood pmid:22294726
Cho HY et al. Perillyl alcohol for the treatment of temozolomide-resistant gliomas. 2012 Mol. Cancer Ther. pmid:22933703
da Silveira Fd et al. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. 2012 J. Cancer Res. Clin. Oncol. pmid:22481252
Sundin T et al. The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells. 2012 Biochimie pmid:22902867
Duelund L et al. Influence of the active compounds of Perilla frutescens leaves on lipid membranes. 2012 J. Nat. Prod. pmid:22272932
Bicas JL et al. Evaluation of the antioxidant and antiproliferative potential of bioflavors. 2011 Food Chem. Toxicol. pmid:21540069
Khan AQ et al. Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. 2011 Toxicology pmid:20923693
de Saldanha da Gama Fischer J et al. Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol. 2011 J. Proteome Res. pmid:20806975
da Fonseca CO et al. Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma. 2011 J. Cancer Res. Clin. Oncol. pmid:20401670
Prado R et al. Nonmelanoma skin cancer chemoprevention. 2011 Dermatol Surg pmid:21895847
Kiran I Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium. 2011 Nat Prod Commun pmid:22312710
Cornelissen S et al. Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization. 2011 J. Ind. Microbiol. Biotechnol. pmid:21559976
Seifert A et al. An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. 2011 Chembiochem pmid:21591046
Garcia DG et al. The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor. 2010 Mol. Cell. Biochem. pmid:20689980
Stratton SP et al. A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. 2010 Cancer Prev Res (Phila) pmid:20103724
Clifford JL and DiGiovanni J The promise of natural products for blocking early events in skin carcinogenesis. 2010 Cancer Prev Res (Phila) pmid:20103730
Fischer Jde S et al. Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol. 2010 J Proteomics pmid:20083244
Yeruva L et al. Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin. 2010 Anticancer Drugs pmid:19820395
Chaudhary SC et al. Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. 2009 Chem. Biol. Interact. pmid:19161993
Da Fonseca CO et al. Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol. 2009 Invest New Drugs pmid:19139816
Magkouta S et al. Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma. 2009 Nutr Cancer pmid:19838938
Zhou W et al. Components of lemon essential oil attenuate dementia induced by scopolamine. 2009 Nutr Neurosci pmid:19356307
Kim D and Ortiz de Montellano PR Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. 2009 Biotechnol. Lett. pmid:19458919
da Fonseca CO et al. Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. 2008 Jul-Aug Arch. Immunol. Ther. Exp. (Warsz.) pmid:18726148
Fischer Jde S et al. Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol. 2008 J. Exp. Ther. Oncol. pmid:19227008
Matos JM et al. A pilot study of perillyl alcohol in pancreatic cancer. 2008 J. Surg. Res. pmid:18498869