Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Ayar A et al. | Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. | 1998 | Acta Biochim. Pol. | pmid:9821863 |
| Bibel DJ et al. | Sphingosines: antimicrobial barriers of the skin. | 1993 | Acta Derm. Venereol. | pmid:7906449 |
| Baranowski M et al. | Exercise increases plasma levels of sphingoid base-1 phosphates in humans. | 2011 | Acta Physiol (Oxf) | pmid:21535416 |
| Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
| Knapp M et al. | Dose-dependent effect of aspirin on the level of sphingolipids in human blood. | 2013 | Adv Med Sci | pmid:24101372 |
| Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
| Nowak DM et al. | Sphingosine and sphinganine levels in human mesothelial cells in vitro as a potential index of signal transduction pathways impacted by microbes and osmolality. | 1998 | Adv Perit Dial | pmid:10649716 |
| Siow DL et al. | Sphingosine kinase localization in the control of sphingolipid metabolism. | 2011 | Adv. Enzyme Regul. | pmid:21075134 |
| Gault CR et al. | An overview of sphingolipid metabolism: from synthesis to breakdown. | 2010 | Adv. Exp. Med. Biol. | pmid:20919643 |