Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphinganine?

Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphinganine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Swine Diseases D013553 16 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with Sphinganine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphinganine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphinganine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphinganine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphinganine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphinganine?

Knock-out

Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).

Mouse Model

Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphinganine

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Authors Title Published Journal PubMed Link
pmid:
HAKOMORI S and MASAMUNE H Chemistry and biology of lipids. XXIII. A new color reaction of sphingosine and dihydrosphingosine. 1956 Tohoku J. Exp. Med. pmid:13371598
Wells GB and Lester RL The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids. 1983 J. Biol. Chem. pmid:6350287
Sonnino S et al. High performance liquid chromatography preparation of the molecular species of GM1 and GD1a gangliosides with homogeneous long chain base composition. 1984 J. Lipid Res. pmid:6747465
Crossman MW and Hirschberg CB Conversion of erythro-D-sphinganine to its [1-2H1] and [1-3H1] derivatives. 1984 J. Lipid Res. pmid:6481245
Crossman MW and Hirschberg CB Biosynthesis of 4D-hydroxysphinganine by the rat. En bloc incorporation of the sphinganine carbon backbone. 1984 Biochim. Biophys. Acta pmid:6477953
Bouhours D and Bouhours JF Developmental changes of the lipidic part of the neutral glycosphingolipids of the rat stomach. 1985 J. Biol. Chem. pmid:3972786
Wilson E et al. Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. 1986 J. Biol. Chem. pmid:3017982
Merrill AH et al. Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. 1986 J. Biol. Chem. pmid:3462189
Vermelho AB et al. Isolation and characterization of a neutral glycosphingolipid from the epimastigote form of Trypanosoma mega. 1986 J. Protozool. pmid:3735150