Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphinganine?

Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphinganine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Swine Diseases D013553 16 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with Sphinganine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphinganine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphinganine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Sphinganine?

Related references are published most in these journals:

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What genes are associated with Sphinganine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphinganine?

Knock-out

Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).

Mouse Model

Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphinganine

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Authors Title Published Journal PubMed Link
Książek M et al. Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. 2018 Cell. Physiol. Biochem. pmid:29316552
Jiang R et al. Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway. 2017 Mol Med Rep pmid:28901444
Song L et al. Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction. 2017 J. Proteome Res. pmid:28722418
Koch A et al. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. 2017 Int J Mol Sci pmid:28714882
Yanagawa D et al. Synthesis and degradation of long-chain base phosphates affect fumonisin B-induced cell death in Arabidopsis thaliana. 2017 J. Plant Res. pmid:28303405
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Školová B et al. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. 2017 Biochim. Biophys. Acta pmid:28109750
Yu M et al. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. 2017 Int J Mol Sci pmid:28287417
Jang Y et al. Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. 2017 J. Nutr. Biochem. pmid:28456081
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Gao H et al. Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine. 2016 Sci Rep pmid:27338781
Olmo ED et al. Efficacious In Vitro and In Vivo Effects of Dihydrosphingosine-Ethambutol Analogues Against Susceptible and Multi-drug-resistant Mycobacterium tuberculosis. 2016 Arch. Med. Res. pmid:27664485
Testard A et al. Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells. 2016 Plant Cell Physiol. pmid:27585463
Vijai Kumar Reddy T et al. Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. 2016 Eur J Med Chem pmid:27128176
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Uemura M et al. Inhibitory Effect of Dihydrosphingosine with α-Tocopherol on Volatile Formation during the Autoxidation of Polyunsaturated Triacylglycerols. 2016 J Oleo Sci pmid:27477074
Grammatikos G et al. Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels. 2016 Int J Mol Sci pmid:27304952
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Cukkemane N et al. Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans. 2015 Eur. J. Oral Sci. pmid:26094809
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Siow D et al. Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. 2015 Adv Biol Regul pmid:25319495
Valentijn-Benz M et al. Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. 2015 Caries Res. pmid:25300299
Kurek K et al. Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. 2015 J Diabetes Res pmid:26380311
Megson ZA et al. Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol. 2015 Biochim. Biophys. Acta pmid:26277409
Tsukamoto S et al. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. 2015 Mol. Cancer Ther. pmid:26264277
Zhang SQ et al. Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport. 2015 Virulence pmid:26220356
Poulsen C et al. Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. 2015 Toxicol. Lett. pmid:26005054
Wang W and Fromm M Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. 2015 PLoS ONE pmid:25906159
Boczkowska-Radziwon B et al. Ozonation of human blood increases sphingosine-1-phosphate in plasma. 2015 J. Physiol. Pharmacol. pmid:25903957
Grenier B et al. Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins. 2015 Toxins (Basel) pmid:25871822
Magnin-Robert M et al. Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis. 2015 Plant Physiol. pmid:26378098
Tan KB et al. Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. 2014 Nanomedicine (Lond) pmid:24294981
Poersch AB et al. Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks. 2014 Vet. Microbiol. pmid:25219295
Wollenberg A et al. Immunological and molecular targets of atopic dermatitis treatment. 2014 Br. J. Dermatol. pmid:24720588
Silveira-Dorta G et al. Direct stereoselective synthesis of enantiomerically pure anti-β-amino alcohols. 2014 J. Org. Chem. pmid:24708186
Tanaka K et al. Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells. 2014 Glycoconj. J. pmid:24310545
Jirošová A et al. Sphinganine-like biogenesis of (E)-1-nitropentadec-1-ene in termite soldiers of the genus Prorhinotermes. 2014 Chembiochem pmid:24458870
Noack J et al. A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. 2014 Cell Death Dis pmid:25255218
Farhat M et al. Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. 2014 Cell Death Dis pmid:24787013
Hamada M et al. Involvement of hydrogen peroxide in safingol-induced endonuclease G-mediated apoptosis of squamous cell carcinoma cells. 2014 Int J Mol Sci pmid:24549171
Klug YA et al. Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. 2014 Biochem. J. pmid:24766462
Dekker MJ et al. Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. 2013 Atherosclerosis pmid:23466071
Chabowski A et al. Fiber specific changes in sphingolipid metabolism in skeletal muscles of hyperthyroid rats. 2013 Lipids pmid:23467817
Burel C et al. Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella. 2013 Toxins (Basel) pmid:23612754
Hu L et al. TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. 2013 Tumour Biol. pmid:23616010
Tibboel J et al. Amelioration of hyperoxia-induced lung injury using a sphingolipid-based intervention. 2013 Eur. Respir. J. pmid:23143542
Fischer CL et al. Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage. 2013 Skin Pharmacol Physiol pmid:23128426
Qin DD et al. syn- and enantioselective Henry reactions of aliphatic aldehydes and application to the synthesis of safingol. 2013 Chemistry pmid:24281803
Marrouchi R et al. Toxic c17-sphinganine analogue mycotoxin, contaminating tunisian mussels, causes flaccid paralysis in rodents. 2013 Mar Drugs pmid:24287956
Knapp M et al. Dose-dependent effect of aspirin on the level of sphingolipids in human blood. 2013 Adv Med Sci pmid:24101372
Holliday MW et al. C22:0- and C24:0-dihydroceramides confer mixed cytotoxicity in T-cell acute lymphoblastic leukemia cell lines. 2013 PLoS ONE pmid:24040340
Figueiredo JM et al. Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. 2012 Mar-Apr Mol. Biochem. Parasitol. pmid:22226824
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Berkey R et al. Sphingolipids and plant defense/disease: the "death" connection and beyond. 2012 Front Plant Sci pmid:22639658
Siddique MM et al. Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. 2012 PLoS ONE pmid:22984457
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Healey KR et al. CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. 2012 Mol. Microbiol. pmid:22909030
Shea BS and Tager AM Sphingolipid regulation of tissue fibrosis. 2012 Open Rheumatol J pmid:22802910
Petrov VD and Van Breusegem F Hydrogen peroxide-a central hub for information flow in plant cells. 2012 AoB Plants pmid:22708052
Wang L et al. Proteomic analysis of Rta2p-dependent raft-association of detergent-resistant membranes in Candida albicans. 2012 PLoS ONE pmid:22662216
Fischer CL et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. 2012 Antimicrob. Agents Chemother. pmid:22155833
Kimura T et al. Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice. 2012 PPAR Res pmid:22645601
Guo L and Wang X Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling. 2012 Front Plant Sci pmid:22639650
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Longato L et al. Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. 2012 Oxid Med Cell Longev pmid:22577490
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Demirkan A et al. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. 2012 PLoS Genet. pmid:22359512
Frank S et al. Structural characterization of Schistosoma mansoni adult worm glycosphingolipids reveals pronounced differences with those of cercariae. 2012 Glycobiology pmid:22241826
Montefusco DJ et al. Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. 2012 J. Biol. Chem. pmid:22277656
Zhao YY et al. Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS. 2012 Clin. Chim. Acta pmid:22227165
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Nakagawa N et al. Degradation of long-chain base 1-phosphate (LCBP) in Arabidopsis: functional characterization of LCBP phosphatase involved in the dehydration stress response. 2012 J. Plant Res. pmid:21910031
Dangerfield EM et al. Species-specific activity of glycolipid ligands for invariant NKT cells. 2012 Chembiochem pmid:22639457
Anand K et al. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. 2012 PLoS ONE pmid:22574179
Benlasher E et al. Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys. 2012 Avian Dis. pmid:22545537
Callihan P et al. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. 2012 Neuropharmacology pmid:22016110
Sun Y et al. Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. 2012 Mol. Biol. Cell pmid:22535525
Gelineau-van Waes J et al. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. 2012 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:22991331
Knapp M et al. Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. 2012 Basic Res. Cardiol. pmid:22961594
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Tan KB et al. In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia. 2012 J Control Release pmid:22100388
Kim HJ et al. A fluorescent assay for ceramide synthase activity. 2012 J. Lipid Res. pmid:22661289
Vizcarra-Olvera JE et al. Evaluation of pathological effects in broilers during fumonisins and clays exposure. 2012 Mycopathologia pmid:22396010
Vandenbosch D et al. Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. 2012 Antimicrob. Agents Chemother. pmid:22354293
Meyer SG et al. Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells. 2012 Arch. Biochem. Biophys. pmid:22841978
Ashkenazi A et al. Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1. 2012 FASEB J. pmid:22872679
Jiang Q et al. Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide. 2012 Int. J. Cancer pmid:21400505
Rauber RH et al. Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens. 2012 Poult. Sci. pmid:23091133
Knapp M et al. Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. 2012 Adv Med Sci pmid:22296975