Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Książek M et al. | Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. | 2018 | Cell. Physiol. Biochem. | pmid:29316552 |
| Jiang R et al. | Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway. | 2017 | Mol Med Rep | pmid:28901444 |
| Song L et al. | Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction. | 2017 | J. Proteome Res. | pmid:28722418 |
| Koch A et al. | Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. | 2017 | Int J Mol Sci | pmid:28714882 |
| Yanagawa D et al. | Synthesis and degradation of long-chain base phosphates affect fumonisin B-induced cell death in Arabidopsis thaliana. | 2017 | J. Plant Res. | pmid:28303405 |
| Chen Y et al. | Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE mice fed a high-fat diet. | 2017 | Atherosclerosis | pmid:28527370 |
| Školová B et al. | Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. | 2017 | Biochim. Biophys. Acta | pmid:28109750 |
| Yu M et al. | The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. | 2017 | Int J Mol Sci | pmid:28287417 |
| Jang Y et al. | Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. | 2017 | J. Nutr. Biochem. | pmid:28456081 |
| Xu H et al. | Serum Metabonomics of Mild Acute Pancreatitis. | 2016 | J. Clin. Lab. Anal. | pmid:27169745 |
| Gao H et al. | Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine. | 2016 | Sci Rep | pmid:27338781 |
| Olmo ED et al. | Efficacious In Vitro and In Vivo Effects of Dihydrosphingosine-Ethambutol Analogues Against Susceptible and Multi-drug-resistant Mycobacterium tuberculosis. | 2016 | Arch. Med. Res. | pmid:27664485 |
| Testard A et al. | Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells. | 2016 | Plant Cell Physiol. | pmid:27585463 |
| Vijai Kumar Reddy T et al. | Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents. | 2016 | Eur J Med Chem | pmid:27128176 |
| Arias SL et al. | Toxin distribution and sphingoid base imbalances in Fusarium verticillioides-infected and fumonisin B1-watered maize seedlings. | 2016 | Phytochemistry | pmid:26903312 |
| Pastor-Flores D et al. | Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1. | 2016 | Biochim. Biophys. Acta | pmid:26743850 |
| Luttgeharm KD et al. | Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. | 2016 | Biochem. J. | pmid:26635357 |
| Uemura M et al. | Inhibitory Effect of Dihydrosphingosine with α-Tocopherol on Volatile Formation during the Autoxidation of Polyunsaturated Triacylglycerols. | 2016 | J Oleo Sci | pmid:27477074 |
| Grammatikos G et al. | Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels. | 2016 | Int J Mol Sci | pmid:27304952 |
| Masching S et al. | Gastrointestinal Degradation of Fumonisin Bâ‚ by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine. | 2016 | Toxins (Basel) | pmid:27007395 |
| Güntert T et al. | 1-Deoxysphingolipid-induced neurotoxicity involves N-methyl-d-aspartate receptor signaling. | 2016 | Neuropharmacology | pmid:27016021 |
| Cukkemane N et al. | Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans. | 2015 | Eur. J. Oral Sci. | pmid:26094809 |
| Denli M et al. | Efficacy of AdiDetoxâ„¢ in reducing the toxicity of fumonisin B1 in rats. | 2015 | Food Chem. Toxicol. | pmid:25660482 |
| Hahn I et al. | Effects of orally administered fumonisin Bâ‚ (FBâ‚), partially hydrolysed FBâ‚, hydrolysed FBâ‚ and N-(1-deoxy-D-fructos-1-yl) FBâ‚ on the sphingolipid metabolism in rats. | 2015 | Food Chem. Toxicol. | pmid:25475052 |
| Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
| Valentijn-Benz M et al. | Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. | 2015 | Caries Res. | pmid:25300299 |
| Kurek K et al. | Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. | 2015 | J Diabetes Res | pmid:26380311 |
| Megson ZA et al. | Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol. | 2015 | Biochim. Biophys. Acta | pmid:26277409 |
| Tsukamoto S et al. | Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs. | 2015 | Mol. Cancer Ther. | pmid:26264277 |
| Zhang SQ et al. | Mutation of G234 amino acid residue in candida albicans drug-resistance-related protein Rta2p is associated with fluconazole resistance and dihydrosphingosine transport. | 2015 | Virulence | pmid:26220356 |
| Poulsen C et al. | Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. | 2015 | Toxicol. Lett. | pmid:26005054 |
| Wang W and Fromm M | Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. | 2015 | PLoS ONE | pmid:25906159 |
| Boczkowska-Radziwon B et al. | Ozonation of human blood increases sphingosine-1-phosphate in plasma. | 2015 | J. Physiol. Pharmacol. | pmid:25903957 |
| Grenier B et al. | Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins. | 2015 | Toxins (Basel) | pmid:25871822 |
| Magnin-Robert M et al. | Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis. | 2015 | Plant Physiol. | pmid:26378098 |
| Tan KB et al. | Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. | 2014 | Nanomedicine (Lond) | pmid:24294981 |
| Poersch AB et al. | Involvement of oxidative stress in subacute toxicity induced by fumonisin B1 in broiler chicks. | 2014 | Vet. Microbiol. | pmid:25219295 |
| Wollenberg A et al. | Immunological and molecular targets of atopic dermatitis treatment. | 2014 | Br. J. Dermatol. | pmid:24720588 |
| Silveira-Dorta G et al. | Direct stereoselective synthesis of enantiomerically pure anti-β-amino alcohols. | 2014 | J. Org. Chem. | pmid:24708186 |
| Tanaka K et al. | Individual profiles of free ceramide species and the constituent ceramide species of sphingomyelin and neutral glycosphingolipid and their alteration according to the sequential changes of environmental oxygen content in human colorectal cancer Caco-2 cells. | 2014 | Glycoconj. J. | pmid:24310545 |
| Jirošová A et al. | Sphinganine-like biogenesis of (E)-1-nitropentadec-1-ene in termite soldiers of the genus Prorhinotermes. | 2014 | Chembiochem | pmid:24458870 |
| Noack J et al. | A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy. | 2014 | Cell Death Dis | pmid:25255218 |
| Farhat M et al. | Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. | 2014 | Cell Death Dis | pmid:24787013 |
| Hamada M et al. | Involvement of hydrogen peroxide in safingol-induced endonuclease G-mediated apoptosis of squamous cell carcinoma cells. | 2014 | Int J Mol Sci | pmid:24549171 |
| Klug YA et al. | Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site. | 2014 | Biochem. J. | pmid:24766462 |
| Dekker MJ et al. | Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. | 2013 | Atherosclerosis | pmid:23466071 |
| Chabowski A et al. | Fiber specific changes in sphingolipid metabolism in skeletal muscles of hyperthyroid rats. | 2013 | Lipids | pmid:23467817 |
| Burel C et al. | Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella. | 2013 | Toxins (Basel) | pmid:23612754 |
| Hu L et al. | TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. | 2013 | Tumour Biol. | pmid:23616010 |
| Tibboel J et al. | Amelioration of hyperoxia-induced lung injury using a sphingolipid-based intervention. | 2013 | Eur. Respir. J. | pmid:23143542 |