Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of Sphinganine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphinganine is suspected in Pulmonary Edema, Morphologically altered structure, Infection, HIV Infections, Pulmonary Hypertension, Exanthema and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Sphinganine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Swine Diseases | D013553 | 16 associated lipids |
| Scleroderma, Systemic | D012595 | 16 associated lipids |
| Abortion, Spontaneous | D000022 | 12 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast.' (Watanabe R et al., 2002) and Knock-out are used in the study 'Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.' (Jenkins GM and Hannun YA, 2001).
Mouse Model are used in the study 'Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.' (Hu W et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gao H et al. | Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine. | 2016 | Sci Rep | pmid:27338781 |
| Cukkemane N et al. | Anti-adherence and bactericidal activity of sphingolipids against Streptococcus mutans. | 2015 | Eur. J. Oral Sci. | pmid:26094809 |
| Denli M et al. | Efficacy of AdiDetoxâ„¢ in reducing the toxicity of fumonisin B1 in rats. | 2015 | Food Chem. Toxicol. | pmid:25660482 |
| Hahn I et al. | Effects of orally administered fumonisin Bâ‚ (FBâ‚), partially hydrolysed FBâ‚, hydrolysed FBâ‚ and N-(1-deoxy-D-fructos-1-yl) FBâ‚ on the sphingolipid metabolism in rats. | 2015 | Food Chem. Toxicol. | pmid:25475052 |
| Siow D et al. | Regulation of de novo sphingolipid biosynthesis by the ORMDL proteins and sphingosine kinase-1. | 2015 | Adv Biol Regul | pmid:25319495 |
| Valentijn-Benz M et al. | Sphingoid bases inhibit acid-induced demineralization of hydroxyapatite. | 2015 | Caries Res. | pmid:25300299 |
| Poulsen C et al. | Differential cytotoxicity of long-chain bases for human oral gingival epithelial keratinocytes, oral fibroblasts, and dendritic cells. | 2015 | Toxicol. Lett. | pmid:26005054 |
| Wang W and Fromm M | Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes. | 2015 | PLoS ONE | pmid:25906159 |
| Boczkowska-Radziwon B et al. | Ozonation of human blood increases sphingosine-1-phosphate in plasma. | 2015 | J. Physiol. Pharmacol. | pmid:25903957 |
| Grenier B et al. | Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins. | 2015 | Toxins (Basel) | pmid:25871822 |