Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Per page 10 20 50 100 | Total 101

PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Tang HB et al. S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. 2018 Biochem. Biophys. Res. Commun. pmid:29534963
Yu FC et al. Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury. 2018 Biochem. Biophys. Res. Commun. pmid:29550481
Nádró B et al. [The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis]. 2018 Orv Hetil pmid:29376427
Deshpande GP et al. Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). 2018 Life Sci. pmid:29373815
Książek M et al. Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. 2018 Cell. Physiol. Biochem. pmid:29316552
Huang Y et al. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. 2018 Science pmid:29302015
Ogretmen B Sphingolipid metabolism in cancer signalling and therapy. 2018 Nat. Rev. Cancer pmid:29147025
Atkinson D et al. Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. 2017 Neurology pmid:28077491
Ng ML et al. The role of sphingolipid signalling in diabetes‑associated pathologies (Review). 2017 Int. J. Mol. Med. pmid:28075451
van der Weyden L et al. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. 2017 Nature pmid:28052056
Lima S et al. Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. 2017 J. Biol. Chem. pmid:28049734
Ogle ME et al. Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. 2017 Stem Cells pmid:28026131
Yung BS et al. Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. 2017 J. Mol. Cell. Cardiol. pmid:28017639
Contaifer D et al. Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. 2017 J. Lipid Res. pmid:27993949
Myśliwiec H et al. Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. 2017 Arch. Dermatol. Res. pmid:27988894
Powell JA et al. Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. 2017 Blood pmid:27956387
Miyabe C et al. A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. 2017 Inflamm. Res. pmid:27942751
Williams PA et al. Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. 2017 Ann Biomed Eng pmid:27904998
Zhao Z et al. Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. 2017 Acta Haematol. pmid:27802432
González-Fernández B et al. Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. 2017 Biofactors pmid:27801960
McLean CJ et al. Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. 2017 J. Lipid Res. pmid:27784725
Abraham C et al. Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. 2017 Gastroenterology pmid:27780712
Pal SK et al. A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. 2017 Cancer pmid:27727447
Lim J et al. Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. 2017 Int. J. Mol. Med. pmid:28677769
Katsuta E et al. Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. 2017 J. Surg. Res. pmid:29078883
Vogt D and Stark H Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. 2017 Med Res Rev pmid:27480072
Olesch C et al. Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. 2017 Mediators Inflamm. pmid:28848247
Egom EE et al. Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. 2017 Int J Mol Sci pmid:28820460
Swendeman SL et al. An engineered S1P chaperone attenuates hypertension and ischemic injury. 2017 Sci Signal pmid:28811382
Syed SN et al. S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. 2017 Mediators Inflamm. pmid:28804221
Doan NB et al. Acid ceramidase confers radioresistance to glioblastoma cells. 2017 Oncol. Rep. pmid:28765947
Arish M et al. Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. 2017 J. Recept. Signal Transduct. Res. pmid:28758826
Polzin A et al. Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. 2017 J. Mol. Cell. Cardiol. pmid:28709768
Innamorati G et al. Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. 2017 Cell Death Dis pmid:28703804
Bougault C et al. Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. 2017 Bone pmid:28684192
Tsai CH et al. Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. 2017 Mol Oncol pmid:28672103
Schmidt KG et al. Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. 2017 Front Immunol pmid:29033951
Xie Z et al. Targeting sphingosine-1-phosphate signaling for cancer therapy. 2017 Sci China Life Sci pmid:28623546
Yanagida K et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. 2017 Proc. Natl. Acad. Sci. U.S.A. pmid:28396408
Takahashi C et al. Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. 2017 J. Atheroscler. Thromb. pmid:28321011
Pierucci F et al. Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. 2017 Neuropharmacology pmid:28077289
Leo A et al. The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. 2017 CNS Neurol Disord Drug Targets pmid:27823573
Roch L et al. High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. 2017 Mol. Neurobiol. pmid:27631876
Vu TM et al. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. 2017 Nature pmid:29045386
Reinhard NR et al. The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. 2017 Mol. Biol. Cell pmid:28954861
Natarajan V et al. Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. 2017 BMC Genomics pmid:28851267
Hajny S and Christoffersen C A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. 2017 Int J Mol Sci pmid:28749426
Bertlich M et al. Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. 2017 Otol. Neurotol. pmid:28742634
Koch A et al. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. 2017 Int J Mol Sci pmid:28714882
Alqinyah M et al. Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. 2017 Mol. Pharmacol. pmid:28031332
Zeng Y Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. 2017 J. Cell. Mol. Med. pmid:28211170
Sun XJ et al. Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. 2017 Nephrol. Dial. Transplant. pmid:28206609
Janecke AR et al. Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. 2017 Hum. Mutat. pmid:28181337
Ebenezer DL et al. Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. 2017 Adv Biol Regul pmid:27720306
Moritz E et al. Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. 2017 Clin. Chim. Acta pmid:28159438
Winkler MS et al. Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? 2017 Shock pmid:27922551
Chen T et al. Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. 2017 Front Biosci (Landmark Ed) pmid:27814635
Beider K et al. The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. 2017 Clin. Cancer Res. pmid:27697999
Feuerborn R et al. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. 2017 Atherosclerosis pmid:28038379
Thieme M et al. Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. 2017 Exp. Dermatol. pmid:27574180
Chang N et al. HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. 2017 J. Mol. Med. pmid:27543493
Gudipaty SA and Rosenblatt J Epithelial cell extrusion: Pathways and pathologies. 2017 Semin. Cell Dev. Biol. pmid:27212253
Wang M et al. Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. 2017 PLoS ONE pmid:29136008
Tran HB et al. Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. 2017 PLoS ONE pmid:29112690
Mensah SA et al. Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. 2017 PLoS ONE pmid:29023478
Wang X et al. Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. 2017 Exp. Mol. Pathol. pmid:28986246
Werth S et al. Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. 2017 J. Endocrinol. pmid:28970286
Du Y et al. Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. 2017 Cell. Physiol. Biochem. pmid:28934733
Kuchler L et al. Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. 2017 Mol. Immunol. pmid:28846923
Nicholas SE et al. Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. 2017 PLoS ONE pmid:28806736
Lee SY et al. Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. 2017 Diabetes pmid:28698261
Hutami IR et al. Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. 2017 Biochem. Biophys. Res. Commun. pmid:28687489
Cannavo A et al. β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. 2017 J. Am. Coll. Cardiol. pmid:28683966
Punsawad C and Viriyavejakul P Reduction in serum sphingosine 1-phosphate concentration in malaria. 2017 PLoS ONE pmid:28666023
Luo J et al. The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. 2017 Biochem. Biophys. Res. Commun. pmid:28655617
Chang CH and Randolph GJ Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. 2017 Dev. Cell pmid:28633013
Fang R et al. Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. 2017 Arch. Med. Res. pmid:28625317
Rohrbach T et al. Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. 2017 Crit. Rev. Biochem. Mol. Biol. pmid:28618839
Vijayan M et al. Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. 2017 J. Immunol. pmid:28600291
White CR et al. High-Density Lipoprotein Regulation of Mitochondrial Function. 2017 Adv. Exp. Med. Biol. pmid:28551800
King A et al. Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. 2017 Gastroenterology pmid:28363640
Wollny T et al. Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. 2017 Int J Mol Sci pmid:28362332
Denimal D et al. Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28360087
Gusman DH and Shoemake C Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. 2017 Yale J Biol Med pmid:28356890
Andrieu G et al. Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. 2017 Sci Signal pmid:28351953
Becker S et al. Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. 2017 PLoS ONE pmid:28334008
Karunakaran I and van Echten-Deckert G Sphingosine 1-phosphate - A double edged sword in the brain. 2017 Biochim. Biophys. Acta pmid:28315304
Navarrete A et al. A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. 2017 J Pharm Biomed Anal pmid:28314215
Shirakawa H et al. Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. 2017 Glia pmid:28300348
Dyckman AJ Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. 2017 J. Med. Chem. pmid:28291340
Nielsen OH et al. Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. 2017 Trends Mol Med pmid:28283249
Peyrin-Biroulet L et al. Modulation of sphingosine-1-phosphate in inflammatory bowel disease. 2017 Autoimmun Rev pmid:28279838
Miller M et al. Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. 2017 J. Immunol. pmid:28275141
Tafelmeier M et al. Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. 2017 J. Steroid Biochem. Mol. Biol. pmid:27163393
Su K et al. FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. 2017 Mediators Inflamm. pmid:28270699
Serafimidis I et al. Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. 2017 PLoS Biol. pmid:28248965
Lee HM et al. Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. 2017 J. Pathol. pmid:28240350
Rieck M et al. Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. 2017 Eur. J. Immunol. pmid:28198542
Bruno M et al. Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. 2017 Biochim. Biophys. Acta pmid:28188805
Qi H et al. Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. 2017 J. Lipid Res. pmid:28188148