sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
Ohtoyo M et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. 2016 Lipids pmid:27585475
Gardner NM et al. Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. 2016 Toxicol. Appl. Pharmacol. pmid:26905748
Grammatikos G et al. Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. 2016 Oncotarget pmid:26933996
Riley RT et al. A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 2015 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:25833119
Magnin-Robert M et al. Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis. 2015 Plant Physiol. pmid:26378098
Shimizu Y et al. Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. 2014 Am. J. Pathol. pmid:24641902
Ceglarek U et al. Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. 2014 Clin. Chim. Acta pmid:24768784
Barth BM et al. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. 2013 ACS Nano pmid:23373542
Gelineau-van Waes J et al. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. 2012 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:22991331
Knapp M et al. Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. 2012 Basic Res. Cardiol. pmid:22961594