sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?

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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
Ohtoyo M et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. 2016 Lipids pmid:27585475
Gardner NM et al. Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. 2016 Toxicol. Appl. Pharmacol. pmid:26905748
Grammatikos G et al. Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. 2016 Oncotarget pmid:26933996
Riley RT et al. A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 2015 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:25833119
Magnin-Robert M et al. Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis. 2015 Plant Physiol. pmid:26378098
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Ceglarek U et al. Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. 2014 Clin. Chim. Acta pmid:24768784
Barth BM et al. PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate. 2013 ACS Nano pmid:23373542
Jin YX et al. A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. 2012 Bioresour. Technol. pmid:22940331
Gorshkova I et al. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. 2012 J. Lipid Res. pmid:22615416
Callihan P et al. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. 2012 Neuropharmacology pmid:22016110
Gelineau-van Waes J et al. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. 2012 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:22991331
Knapp M et al. Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. 2012 Basic Res. Cardiol. pmid:22961594
Sánchez BA et al. Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination. 2011 Anal Bioanal Chem pmid:21394454
Baranowski M et al. Exercise increases plasma levels of sphingoid base-1 phosphates in humans. 2011 Acta Physiol (Oxf) pmid:21535416
Yonamine I et al. Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. 2011 J. Cell Biol. pmid:21321100
Argraves KM et al. S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease. 2011 Lipids Health Dis pmid:21554699
Bu S et al. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. 2010 Arthritis Rheum. pmid:20309867
Park SW et al. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. 2010 Lab. Invest. pmid:20458275
Cutignano A et al. UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. 2010 Prostaglandins Other Lipid Mediat. pmid:20601074
Berdyshev EV et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. 2009 J. Biol. Chem. pmid:19119142
Knapp M et al. Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. 2009 Med. Sci. Monit. pmid:19721401
Scherer M et al. High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. 2009 Clin. Chem. pmid:19325012
Bu S et al. Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. 2008 J. Biol. Chem. pmid:18482992
González-Díez M et al. Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. 2008 Thromb. Haemost. pmid:18612546
Machesky NJ et al. Human cytomegalovirus regulates bioactive sphingolipids. 2008 J. Biol. Chem. pmid:18644793
Coste O et al. Sphingosine 1-phosphate modulates spinal nociceptive processing. 2008 J. Biol. Chem. pmid:18805787
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Cai Q et al. Validation of fumonisin biomarkers in F344 rats. 2007 Toxicol. Appl. Pharmacol. pmid:17904604
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Kim DH et al. Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice. 2007 Arch. Pharm. Res. pmid:17879749
Berdyshev EV et al. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. 2006 Cell. Signal. pmid:16529909
Jiang X and Han X Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. 2006 J. Lipid Res. pmid:16682747
Dahm F et al. Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. 2006 J. Thromb. Haemost. pmid:17010150
Bu S et al. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. 2006 FASEB J. pmid:16278291
Kim DH et al. Elevation of sphinganine 1-phosphate as a predictive biomarker for fumonisin exposure and toxicity in mice. 2006 J. Toxicol. Environ. Health Part A pmid:17060094
Schmidt H et al. LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. 2006 Prostaglandins Other Lipid Mediat. pmid:17085324
Tardieu D et al. Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. 2006 Chem. Biol. Interact. pmid:16412405
Saini HS et al. Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. 2005 J. Neurochem. pmid:16313513
Inagaki Y et al. Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. 2005 Biochem. J. pmid:15733055
Berdyshev EV et al. Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. 2005 Anal. Biochem. pmid:15766719
Fossetta J et al. Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate. 2004 Br. J. Pharmacol. pmid:15197107
Abbey-Hosch SE et al. Sphingosine-1-phosphate inhibits C-type natriuretic peptide activation of guanylyl cyclase B (GC-B/NPR-B). 2004 Hypertension pmid:15037564
Johnson KR et al. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. 2003 J. Biol. Chem. pmid:12815058
Niedernberg A et al. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. 2003 Cell. Signal. pmid:12618218
Kihara A et al. Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. 2003 Genes Cells pmid:12786943
Niedernberg A et al. Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. 2003 J Biomol Screen pmid:14567777
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709
Candelore MR et al. Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. 2002 Biochem. Biophys. Res. Commun. pmid:12270137
Katsuma S et al. Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. 2002 Genes Cells pmid:12485162
Benaud C et al. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. 2002 J. Biol. Chem. pmid:11792696
Uhlenbrock K et al. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. 2002 Cell. Signal. pmid:12220620
Tamama K et al. Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. 2001 Biochem. J. pmid:11115407
Scott RH et al. Synthesis and use of caged sphingolipids. 2000 Meth. Enzymol. pmid:11070887
Chung N and Obeid LM Use of yeast as a model system for studies of sphingolipid metabolism and signaling. 2000 Meth. Enzymol. pmid:10563337
Im DS et al. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. 2000 J. Biol. Chem. pmid:10799507
Van Brocklyn JR et al. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. 2000 Blood pmid:10753843
Mao C and Obeid LM Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. 2000 Meth. Enzymol. pmid:10563329
Van Veldhoven PP Sphingosine-1-phosphate lyase. 2000 Meth. Enzymol. pmid:10563331
Kim S et al. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. 2000 Genetics pmid:11102354
Ancellin N and Hla T Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. 1999 J. Biol. Chem. pmid:10383399
Mao C et al. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. 1999 Biochem. J. pmid:10477278
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Skrzypek MS et al. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. 1999 J. Bacteriol. pmid:9973338
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Okamoto H et al. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. 1998 J. Biol. Chem. pmid:9765227
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Crowther GJ and Lynch DV Characterization of sphinganine kinase activity in corn shoot microsomes. 1997 Arch. Biochem. Biophys. pmid:9016824
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