sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
Tamama K et al. Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. 2001 Biochem. J. pmid:11115407
Candelore MR et al. Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. 2002 Biochem. Biophys. Res. Commun. pmid:12270137
Katsuma S et al. Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. 2002 Genes Cells pmid:12485162
Benaud C et al. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. 2002 J. Biol. Chem. pmid:11792696
Uhlenbrock K et al. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. 2002 Cell. Signal. pmid:12220620
Johnson KR et al. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. 2003 J. Biol. Chem. pmid:12815058
Niedernberg A et al. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. 2003 Cell. Signal. pmid:12618218
Kihara A et al. Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. 2003 Genes Cells pmid:12786943
Niedernberg A et al. Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. 2003 J Biomol Screen pmid:14567777
Arikawa K et al. Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. 2003 J. Biol. Chem. pmid:12810709