sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
Ancellin N and Hla T Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. 1999 J. Biol. Chem. pmid:10383399
Mao C et al. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. 1999 Biochem. J. pmid:10477278
Dickson RC and Lester RL Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. 1999 Biochim. Biophys. Acta pmid:10366774
Skrzypek MS et al. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. 1999 J. Bacteriol. pmid:9973338
Gijsbers S et al. N-acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent. 1999 FEBS Lett. pmid:10405158
Okamoto H et al. EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. 1998 J. Biol. Chem. pmid:9765227
Mao C et al. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. 1997 J. Biol. Chem. pmid:9353337
Crowther GJ and Lynch DV Characterization of sphinganine kinase activity in corn shoot microsomes. 1997 Arch. Biochem. Biophys. pmid:9016824
Boumendjel A and Miller SP Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. 1994 J. Lipid Res. pmid:7897327
Van Veldhoven PP and Mannaerts GP Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence for the existence of a sphingosine phosphatase. 1994 Biochem. J. pmid:8192648
Goldin E et al. Type C Niemann-Pick disease: a murine model of the lysosomal cholesterol lipidosis accumulates sphingosine and sphinganine in liver. 1992 Biochim. Biophys. Acta pmid:1324734
Van Veldhoven PP et al. A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate. 1989 J. Lipid Res. pmid:2754341
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