sphinganine 1-phosphate

sphinganine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphinganine 1-phosphate is associated with abnormalities such as Gonorrhea. The involved functions are known as Signal Transduction, Signal, Process, Cell Proliferation and Biochemical Pathway. Sphinganine 1-phosphate often locates in Protoplasm, soluble and Structure of parenchyma of lung. The associated genes with sphinganine 1-phosphate are MBTPS1 gene, NPTXR gene, MED23 gene, Homologous Gene and LGALS1 gene. The related lipids are Sphingolipids, Fatty Acids, ceramide 1-phosphate, Phosphatidic Acid and dihydroceramide. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphinganine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphinganine 1-phosphate?

sphinganine 1-phosphate is suspected in Gonorrhea and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with sphinganine 1-phosphate

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphinganine 1-phosphate?

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What functions are associated with sphinganine 1-phosphate?


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What lipids are associated with sphinganine 1-phosphate?

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What genes are associated with sphinganine 1-phosphate?

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What common seen animal models are associated with sphinganine 1-phosphate?

Mouse Model

Mouse Model are used in the study 'Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.' (Gorshkova I et al., 2012).

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NCBI Entrez Crosslinks

All references with sphinganine 1-phosphate

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Authors Title Published Journal PubMed Link
González-Díez M et al. Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. 2008 Thromb. Haemost. pmid:18612546
Machesky NJ et al. Human cytomegalovirus regulates bioactive sphingolipids. 2008 J. Biol. Chem. pmid:18644793
Coste O et al. Sphingosine 1-phosphate modulates spinal nociceptive processing. 2008 J. Biol. Chem. pmid:18805787
Berdyshev EV et al. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. 2009 J. Biol. Chem. pmid:19119142
Scherer M et al. High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. 2009 Clin. Chem. pmid:19325012
Knapp M et al. Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction. 2009 Med. Sci. Monit. pmid:19721401
Bu S et al. Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels. 2010 Arthritis Rheum. pmid:20309867
Park SW et al. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. 2010 Lab. Invest. pmid:20458275
Cutignano A et al. UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. 2010 Prostaglandins Other Lipid Mediat. pmid:20601074
Yonamine I et al. Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. 2011 J. Cell Biol. pmid:21321100