sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Baek S et al. DJ-1 Regulates Differentiation of Human Mesenchymal Stem Cells into Smooth Muscle-like Cells in Response to Sphingosylphosphorylcholine. 2017 Proteomics pmid:28949093
Kuchar L et al. Quantitation of plasmatic lysosphingomyelin and lysosphingomyelin-509 for differential screening of Niemann-Pick A/B and C diseases. 2017 Anal. Biochem. pmid:28259515
Kim HJ et al. Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1. 2017 Oncotarget pmid:28209923
Kemppainen K et al. Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. 2016 Cell. Signal. pmid:27634386
Bae YC et al. Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival. 2016 Mol Med Rep pmid:27572900
Vanier MT et al. Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review. 2016 Mol. Genet. Metab. pmid:27339554
Aksu F et al. Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats. 2016 Ren Fail pmid:27309733
Park MK et al. Novel effects of FTY720 on perinuclear reorganization of keratin network induced by sphingosylphosphorylcholine: Involvement of protein phosphatase 2A and G-protein-coupled receptor-12. 2016 Eur. J. Pharmacol. pmid:26872988
Wirrig C et al. Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells. 2016 Biochem. Pharmacol. pmid:27402344
Li W et al. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways. 2016 Biochim. Biophys. Acta pmid:27066979
Lee EJ et al. Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells. 2016 Biochim. Biophys. Acta pmid:26876307
Yokota K and Ogino T Phase separation in lipid bilayer membranes induced by intermixing at a boundary of two phases with different components. 2015 Chem. Phys. Lipids pmid:26363303
Tobo A et al. Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses. 2015 PLoS ONE pmid:26070068
Yue HW et al. Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. 2015 Biochim. Biophys. Acta pmid:25871970
Aksu B et al. Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats. 2015 J. Pediatr. Surg. pmid:25840069
El-Najjar N et al. Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. 2015 PLoS ONE pmid:26466367
Hyder CL et al. Sphingolipids inhibit vimentin-dependent cell migration. 2015 J. Cell. Sci. pmid:25908861
Shaifta Y et al. Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species. 2015 Cardiovasc. Res. pmid:25661082
Shirao S et al. A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts. 2015 J. Cereb. Blood Flow Metab. pmid:25605290
Chuang WL et al. Lyso-sphingomyelin is elevated in dried blood spots of Niemann-Pick B patients. 2014 Mol. Genet. Metab. pmid:24418695
Yue H et al. Inhibition of autophagy promoted sphingosylphosphorylcholine induced cell death in non-small cell lung cancer cells. 2014 Biochem. Biophys. Res. Commun. pmid:25285628
Wang XQ et al. Sphingosylphosphorylcholine induces α-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P2 receptor and Rho/Rho-kinase pathway. 2014 Prostaglandins Other Lipid Mediat. pmid:24614064
Yoneda H et al. A prospective, multicenter, randomized study of the efficacy of eicosapentaenoic acid for cerebral vasospasm: the EVAS study. 2014 World Neurosurg pmid:23032083
Welford RW et al. Plasma lysosphingomyelin demonstrates great potential as a diagnostic biomarker for Niemann-Pick disease type C in a retrospective study. 2014 PLoS ONE pmid:25479233
Davenport AP et al. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. 2013 Pharmacol. Rev. pmid:23686350
Sakamoto S et al. Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study. 2013 Biochim. Biophys. Acta pmid:23333324
Kim KH et al. Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells. 2012 Exp. Mol. Med. pmid:22127053
Jeong HS et al. PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation. 2012 Mol. Cell. Biochem. pmid:22544520
Busch T et al. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. 2012 J. Cell. Sci. pmid:22344252
Russell JL et al. Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease. 2012 ACS Chem. Biol. pmid:22462679
Yang CR et al. The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. 2012 PLoS ONE pmid:22685609
Ge D et al. Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. 2012 Acta Pharmacol. Sin. pmid:22139003
Xu D et al. Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts. 2012 Cell. Signal. pmid:21951603
Yi H et al. Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. 2011 Neurochem. Res. pmid:21674237
Lee HY et al. Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. 2011 J. Immunol. pmid:21368227
Yamamoto H et al. Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages. 2011 Arch. Biochem. Biophys. pmid:21081108
Ge D et al. Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells. 2011 J. Cell. Physiol. pmid:21302284
Harris LJ et al. Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. 2011 J. Surg. Res. pmid:19959190
Jeong HS et al. Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. 2011 J. Biomed. Sci. pmid:21838918
Park MK et al. Novel participation of transglutaminase-2 through c-Jun N-terminal kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells. 2011 Biochim. Biophys. Acta pmid:21840417
Andoh T et al. Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions. 2011 Exp. Dermatol. pmid:21824199
Wirrig C et al. Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. 2011 J. Cereb. Blood Flow Metab. pmid:20551970
Horii K et al. Development of a sphingosylphosphorylcholine detection system using RNA aptamers. 2010 Molecules pmid:20729797
Kudo R and Hatake K [Effect of ethanol on sphingosylphosphorylcholine (SPC)-induced vasoconstriction in rat artery]. 2010 Nihon Arukoru Yakubutsu Igakkai Zasshi pmid:20681251
Sundh M et al. Influence of phase separating lipids on supported lipid bilayer formation at SiO2 surfaces. 2010 Phys Chem Chem Phys pmid:20023823
Choi H et al. Sphingosylphosphorylcholine down-regulates filaggrin gene transcription through NOX5-based NADPH oxidase and cyclooxygenase-2 in human keratinocytes. 2010 Biochem. Pharmacol. pmid:20230798
Kovacs E et al. Dissociation of calmodulin-target peptide complexes by the lipid mediator sphingosylphosphorylcholine: implications in calcium signaling. 2010 J. Biol. Chem. pmid:19910470
Kim DS et al. Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. 2010 J. Pharm. Pharmacol. pmid:20487197
Kovacs E et al. Regulation of ryanodine receptors by sphingosylphosphorylcholine: involvement of both calmodulin-dependent and -independent mechanisms. 2010 Biochem. Biophys. Res. Commun. pmid:20851108
Herzog C et al. Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. 2010 Mediators Inflamm. pmid:21274265