sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Sugiyama E et al. Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines. 1990 Biochem. Biophys. Res. Commun. pmid:2357225
Ghosh TK et al. Intracellular calcium release mediated by sphingosine derivatives generated in cells. 1990 Science pmid:2163543
Strasberg PM and Callahan JW Lysosphingolipids and mitochondrial function. II. Deleterious effects of sphingosylphosphorylcholine. 1988 Biochem. Cell Biol. pmid:2977568
Sripada PK et al. Partial synthesis and properties of a series of N-acyl sphingomyelins. 1987 J. Lipid Res. pmid:3611973
Hara A and Taketomi T Detection of D-erythro and L-threo sphingosine bases in preparative sphingosylphosphorylcholine and its N-acylated derivatives and some evidence of their different chemical configurations. 1983 J. Biochem. pmid:6654881
Callahan JW et al. Studies on the hydrophobic properties of sphingomyelinase. 1981 Biochem. J. pmid:6272705
DAWSON RM The reported occurrence of sphingosylphosphorylcholine in animal tissues. 1958 Biochem. J. pmid:13522629
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