6-hydroxysphingosine

6-hydroxysphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as Acetylation and Binding (Molecular Function). 6-hydroxysphingosine often locates in Epidermis, Stratum corneum and Skin. The related lipids are N-(alpha-hydroxyoctadecanoyl)phytosphingosine, Fatty Acids and hydroxy fatty acid.

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Introduction

To understand associated biological information of 6-hydroxysphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-hydroxysphingosine?

There are no associated biomedical information in the current reference collection.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 6-hydroxysphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-hydroxysphingosine?

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What functions are associated with 6-hydroxysphingosine?


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What lipids are associated with 6-hydroxysphingosine?

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What genes are associated with 6-hydroxysphingosine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with 6-hydroxysphingosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-hydroxysphingosine

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Total 8
Authors Title Published Journal PubMed Link
pmid:
Stewart ME and Downing DT A new 6-hydroxy-4-sphingenine-containing ceramide in human skin. 1999 J. Lipid Res. pmid:10428979
Chun J et al. First asymmetric synthesis of 6-hydroxy-4-sphingenine-containing ceramides. Use of chiral propargylic alcohols to prepare a lipid found in human skin. 2003 J. Org. Chem. pmid:12530859
Novotný J et al. Synthesis and structure-activity relationships of skin ceramides. 2010 Curr. Med. Chem. pmid:20459376
Wisse P et al. Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy. 2015 J. Org. Chem. pmid:26061009
Hsu FF Complete structural characterization of ceramides as [M-H]- ions by multiple-stage linear ion trap mass spectrometry. 2016 Biochimie pmid:27523779
Stewart ME and Downing DT Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. 1995 J. Invest. Dermatol. pmid:7561168
Robson KJ et al. 6-Hydroxy-4-sphingenine in human epidermal ceramides. 1994 J. Lipid Res. pmid:7868984