MeSH term | MeSH ID | Detail |
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Prostatic Neoplasms | D011471 | 126 associated lipids |
Enigmol is a lipid of Sphingolipids (SP) class. Enigmol is associated with abnormalities such as Dehydration and athymia. The involved functions are known as metaplastic cell transformation, Metabolic Inhibition, Selection, Genetic, Stereochemistry and N acylation. Enigmol often locates in Cytoplasmic matrix, Left lateral lumbar region of abdomen, soluble, Blood and Tissue membrane. The associated genes with Enigmol are MSMP gene, APC gene, Oncogenes, SPATA6 gene and FATE1 gene. The related lipids are Sphingolipids and Fatty Acids. The related experimental models are Xenograft Model, Mouse Model and Cancer Model.
To understand associated biological information of Enigmol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Enigmol is suspected in athymia, Dehydration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Enigmol
MeSH term | MeSH ID | Detail |
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Prostatic Neoplasms | D011471 | 126 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Enigmol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.' (Symolon H et al., 2011).
Xenograft Model are used in the study 'Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.' (Symolon H et al., 2011).
Cancer Model are used in the study 'Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer.' (Symolon H et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Meyer EV et al. | Sphingolipid analogues inhibit development of malaria parasites. | 2012 | ACS Med Chem Lett | pmid:24900369 |
Merrill AH | Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. | 2011 | Chem. Rev. | pmid:21942574 |
Symolon H et al. | Enigmol: a novel sphingolipid analogue with anticancer activity against cancer cell lines and in vivo models for intestinal and prostate cancer. | 2011 | Mol. Cancer Ther. | pmid:21398423 |
Garnier-Amblard EC et al. | Novel synthesis and biological evaluation of enigmols as therapeutic agents for treating prostate cancer. | 2011 | ACS Med Chem Lett | pmid:24900327 |
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