Glucosyl sphingosine is a lipid of Sphingolipids (SP) class. Glucosyl sphingosine is associated with abnormalities such as Sphingolipidoses, Globoid cell leukodystrophy, Sandhoff Disease, Tay-Sachs Disease and Fabry Disease. The involved functions are known as Apoptosis, Acetylation, Infiltration, kinase activity and energy pathways. Glucosyl sphingosine often locates in Lysosomal and Protoplasm. The associated genes with Glucosyl sphingosine are MAPT gene, GALC gene, HEXA gene, PICK1 gene and ELF3 gene. The related lipids are lysoganglioside G(M2), Ganglioside GA2, Lysophosphatidylcholines and globotriaosyl lysosphingolipid.
To understand associated biological information of Glucosyl sphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Glucosyl sphingosine is suspected in Globoid cell leukodystrophy, Sphingolipidoses, Sandhoff Disease, Tay-Sachs Disease, Fabry Disease and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Glucosyl sphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Multiple Myeloma | D009101 | 13 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smith NJ et al. | Reduced cerebral vascularization in experimental neuronopathic Gaucher disease. | 2018 | J. Pathol. | pmid:28981147 |
| Lukas J et al. | Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. | 2017 | Int J Mol Sci | pmid:29053611 |
| Kang L et al. | Successful newborn screening for Gaucher disease using fluorometric assay in China. | 2017 | J. Hum. Genet. | pmid:28356566 |
| Taguchi YV et al. | Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. | 2017 | J. Neurosci. | pmid:28847804 |
| Franco M et al. | Effect of velaglucerase alfa enzyme replacement therapy on red blood cell properties in Gaucher disease. | 2017 | Am. J. Hematol. | pmid:28621801 |
| Murugesan V et al. | Glucosylsphingosine is a key biomarker of Gaucher disease. | 2016 | Am. J. Hematol. | pmid:27441734 |
| Dai M et al. | Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease. | 2016 | PLoS ONE | pmid:27598339 |
| Gramlich PA et al. | A peptide-linked recombinant glucocerebrosidase for targeted neuronal delivery: Design, production, and assessment. | 2016 | J. Biotechnol. | pmid:26795355 |
| Fuller M et al. | Rapid, single-phase extraction of glucosylsphingosine from plasma: A universal screening and monitoring tool. | 2015 | Clin. Chim. Acta | pmid:26232157 |
| Mirzaian M et al. | Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard. | 2015 | Blood Cells Mol. Dis. | pmid:25842368 |