PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.
To understand associated biological information of PSYCHOSINE, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PSYCHOSINE is suspected in Globoid cell leukodystrophy, Enzyme Deficiency, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder, Lysosomal Storage Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with PSYCHOSINE
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Leukodystrophy, Metachromatic | D007966 | 4 associated lipids |
| Leukodystrophy, Globoid Cell | D007965 | 6 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
| Optic Atrophy | D009896 | 2 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with PSYCHOSINE through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.' (White AB et al., 2009).
Streptozotocin Diabetes are used in the study 'Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.' (Jiang X et al., 2009).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Marshall MS et al. | Analysis of age-related changes in psychosine metabolism in the human brain. | 2018 | PLoS ONE | pmid:29481565 |
| Kanie Y et al. | Evaluation of reversed-phase nano liquid chromatography conditions by using reversed-phase thin layer chromatography based on Hansen solubility parameters for the analysis of amphiphilic glycosylsphingolipid transformations. | 2018 | J Chromatogr A | pmid:29290400 |
| Smith NJ et al. | Reduced cerebral vascularization in experimental neuronopathic Gaucher disease. | 2018 | J. Pathol. | pmid:28981147 |
| Lukas J et al. | Glucosylsphingosine Causes Hematological and Visceral Changes in Mice-Evidence for a Pathophysiological Role in Gaucher Disease. | 2017 | Int J Mol Sci | pmid:29053611 |
| Kang L et al. | Successful newborn screening for Gaucher disease using fluorometric assay in China. | 2017 | J. Hum. Genet. | pmid:28356566 |
| Escolar ML et al. | Psychosine, a marker of Krabbe phenotype and treatment effect. | 2017 | Mol. Genet. Metab. | pmid:28579020 |
| D'Auria L et al. | Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe's disease. | 2017 | PLoS ONE | pmid:28531236 |
| Taguchi YV et al. | Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. | 2017 | J. Neurosci. | pmid:28847804 |
| Franco M et al. | Effect of velaglucerase alfa enzyme replacement therapy on red blood cell properties in Gaucher disease. | 2017 | Am. J. Hematol. | pmid:28621801 |
| Misslin C et al. | Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination. | 2017 | PLoS ONE | pmid:29095858 |