cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.
To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with cholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).
Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).
Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Leng E et al. | Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. | 2018 | BMC Complement Altern Med | pmid:29622007 |
Donaldson SH and de Aguiar HB | Molecular Imaging of Cholesterol and Lipid Distributions in Model Membranes. | 2018 | J Phys Chem Lett | pmid:29521507 |
Fraz S et al. | Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). | 2018 | Aquat. Toxicol. | pmid:29494825 |
Heitzig N et al. | Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. | 2018 | Biochim Biophys Acta Mol Cell Biol Lipids | pmid:29306076 |
Johnson QR et al. | Effects of carotenoids on lipid bilayers. | 2018 | Phys Chem Chem Phys | pmid:29349456 |
Samardzija D et al. | Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. | 2018 | Mol. Cell. Endocrinol. | pmid:28859904 |
Ruan B et al. | Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29198709 |
Agrawal S et al. | Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. | 2018 | Nat Rev Nephrol | pmid:29176657 |
Shigematsu T et al. | Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer. | 2018 | J Phys Chem B | pmid:29419298 |
Bhojoo U et al. | Temperature induced lipid membrane restructuring and changes in nanomechanics. | 2018 | Biochim. Biophys. Acta | pmid:29248477 |