cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

Cross Reference

Introduction

To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with cholesterol?

cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with cholesterol

MeSH term MeSH ID Detail
Uterine Diseases D014591 6 associated lipids
Hypercapnia D006935 5 associated lipids
Cysts D003560 4 associated lipids
Urination Disorders D014555 9 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Embolism D004617 3 associated lipids
Heart Diseases D006331 8 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Exophthalmos D005094 3 associated lipids
Vision Disorders D014786 10 associated lipids
Multiple Myeloma D009101 13 associated lipids
Quadriplegia D011782 4 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Adrenal Gland Neoplasms D000310 6 associated lipids
Pheochromocytoma D010673 4 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Osteoporosis D010024 12 associated lipids
Anemia, Aplastic D000741 6 associated lipids
Occupational Diseases D009784 42 associated lipids
Asthma D001249 52 associated lipids
Growth Disorders D006130 5 associated lipids
Kidney Diseases D007674 29 associated lipids
Kidney Calculi D007669 7 associated lipids
Hematuria D006417 13 associated lipids
Weight Gain D015430 101 associated lipids
Bone Cysts D001845 3 associated lipids
Brain Diseases D001927 27 associated lipids
Blood Coagulation Disorders D001778 4 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cadmium Poisoning D002105 6 associated lipids
Infection D007239 6 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Acidosis D000138 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Foreign Bodies D005547 5 associated lipids
Glioma D005910 112 associated lipids
Endocarditis, Bacterial D004697 5 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Bone Diseases D001847 4 associated lipids
Hip Dislocation, Congenital D006618 2 associated lipids
Leukemia P388 D007941 43 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Menstruation Disturbances D008599 3 associated lipids
Calcinosis D002114 5 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Obesity D009765 29 associated lipids
Thrombosis D013927 49 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Diffuse Cerebral Sclerosis of Schilder D002549 8 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Refsum Disease D012035 19 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Carcinoma, Ehrlich Tumor D002286 6 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Lymphoma D008223 18 associated lipids
Femur Head Necrosis D005271 5 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperplasia D006965 34 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Eye Diseases D005128 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Periodontal Diseases D010510 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Lymphoproliferative Disorders D008232 7 associated lipids
Myeloproliferative Disorders D009196 5 associated lipids
Crohn Disease D003424 12 associated lipids
Thalassemia D013789 8 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Hemochromatosis D006432 4 associated lipids
Glaucoma D005901 5 associated lipids
Optic Nerve Diseases D009901 6 associated lipids
Genital Neoplasms, Female D005833 2 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Osteoporosis, Postmenopausal D015663 4 associated lipids
Thyroid Diseases D013959 8 associated lipids
Sinusitis D012852 9 associated lipids
Neoplasms, Multiple Primary D009378 8 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fetal Diseases D005315 8 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Leukocytosis D007964 9 associated lipids
Paraneoplastic Syndromes D010257 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with cholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with cholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with cholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with cholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with cholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with cholesterol?

Knock-out

Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).

Mouse Model

Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).

Disease model

Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with cholesterol

Download all related citations
Per page 10 20 50 100 | Total 171571
Authors Title Published Journal PubMed Link
Leng E et al. Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. 2018 BMC Complement Altern Med pmid:29622007
Donaldson SH and de Aguiar HB Molecular Imaging of Cholesterol and Lipid Distributions in Model Membranes. 2018 J Phys Chem Lett pmid:29521507
Fraz S et al. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). 2018 Aquat. Toxicol. pmid:29494825
Heitzig N et al. Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. 2018 Biochim Biophys Acta Mol Cell Biol Lipids pmid:29306076
Johnson QR et al. Effects of carotenoids on lipid bilayers. 2018 Phys Chem Chem Phys pmid:29349456
Samardzija D et al. Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. 2018 Mol. Cell. Endocrinol. pmid:28859904
Ruan B et al. Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. 2018 Biochem. Biophys. Res. Commun. pmid:29198709
Agrawal S et al. Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. 2018 Nat Rev Nephrol pmid:29176657
Shigematsu T et al. Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer. 2018 J Phys Chem B pmid:29419298
Bhojoo U et al. Temperature induced lipid membrane restructuring and changes in nanomechanics. 2018 Biochim. Biophys. Acta pmid:29248477