cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

Cross Reference

Introduction

To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with cholesterol?

cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with cholesterol

MeSH term MeSH ID Detail
Burnout, Professional D002055 1 associated lipids
Arrhythmia, Sinus D001146 1 associated lipids
Dicrocoeliasis D004011 1 associated lipids
Diabetes Insipidus, Neurogenic D020790 1 associated lipids
Needlestick Injuries D016602 1 associated lipids
Postcholecystectomy Syndrome D017562 1 associated lipids
Aortitis D001025 1 associated lipids
Per page 10 20 50 100 | Total 797

PubChem Associated disorders and diseases

What pathways are associated with cholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with cholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with cholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with cholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with cholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with cholesterol?

Knock-out

Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).

Mouse Model

Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).

Disease model

Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with cholesterol

Download all related citations
Per page 10 20 50 100 | Total 171571
Authors Title Published Journal PubMed Link
pmid:15894832
pmid:15892894
pmid:15899050
pmid:15904635
pmid:15901588
pmid:15893181
pmid:15887425
pmid:15897977
pmid:15896733
pmid:15905737
pmid:15905673
pmid:15905463
pmid:15905421
pmid:15905177
pmid:15904989
pmid:15904871
pmid:15904667
pmid:15904653
pmid:15904636
pmid:15904631
pmid:15904579
pmid:15904556
pmid:15904534
pmid:15903244
pmid:15901895
pmid:15901764
pmid:15901589
pmid:15901582
pmid:15901218
pmid:15900986
pmid:15900307
pmid:15900086
pmid:15899950
pmid:15899949
pmid:15899936
pmid:15899649
pmid:15899484
pmid:15899106
pmid:15899047
pmid:15898958
pmid:15898447
pmid:15898437
pmid:15898435
pmid:15898418
pmid:15898219
pmid:15898067
pmid:15897924
pmid:15897788
pmid:15897787
pmid:15897668
pmid:15897607
pmid:15897342
pmid:15896728
pmid:15896659
pmid:15896310
pmid:15896196
pmid:15895846
pmid:15895844
pmid:15895841
pmid:15895716
pmid:15895675
pmid:15895353
pmid:15895131
pmid:15894980
pmid:15894969
pmid:15894836
pmid:15894808
pmid:15894708
pmid:15894400
pmid:15894114
pmid:15894019
pmid:15893960
pmid:15893756
pmid:15893199
pmid:15893177
pmid:15892164
pmid:15892084
pmid:15891398
pmid:15891386
pmid:15890992
pmid:15890972
pmid:15890890
pmid:15890514
pmid:15890427
pmid:15889943
pmid:15889940
pmid:15889235
pmid:15889234
pmid:15889191
pmid:15888560
pmid:15888484
pmid:15888438
pmid:15888329
pmid:15888318
pmid:15888235
pmid:15888229
pmid:15888225
pmid:15888216
pmid:15888215
pmid:15887477