cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

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To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with cholesterol?

cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with cholesterol

MeSH term MeSH ID Detail
Burnout, Professional D002055 1 associated lipids
Arrhythmia, Sinus D001146 1 associated lipids
Dicrocoeliasis D004011 1 associated lipids
Diabetes Insipidus, Neurogenic D020790 1 associated lipids
Needlestick Injuries D016602 1 associated lipids
Postcholecystectomy Syndrome D017562 1 associated lipids
Aortitis D001025 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with cholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with cholesterol?

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What functions are associated with cholesterol?

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Function Cross reference Weighted score Related literatures

What lipids are associated with cholesterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with cholesterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with cholesterol?


Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).

Mouse Model

Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).

Disease model

Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with cholesterol

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Per page 10 20 50 100 | Total 171571
Authors Title Published Journal PubMed Link
Wang L et al. Oryzanol Modifies High Fat Diet-Induced Obesity, Liver Gene Expression Profile, and Inflammation Response in Mice. 2017 J. Agric. Food Chem. pmid:28853872
Bhattarai K et al. Dietary daidzein, but not genistein, has a hypocholesterolemic effect in non-ovariectomized and ovariectomized female Sprague-Dawley rats on a cholesterol-free diet. 2017 Biosci. Biotechnol. Biochem. pmid:28715285
Chen X et al. Post-Translational Modification of Adiponectin Affects Lipid Accumulation, Proliferation and Migration of Vascular Smooth Muscle Cells. 2017 Cell. Physiol. Biochem. pmid:28848139
Bowman L et al. Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease. 2017 N. Engl. J. Med. pmid:28847206
Kelly SA et al. Whole grain cereals for the primary or secondary prevention of cardiovascular disease. 2017 Cochrane Database Syst Rev pmid:28836672
Ruscitti P et al. Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis: Results from a cross-sectional study. 2017 Medicine (Baltimore) pmid:28834907
Artetxe I et al. Does Ceramide Form Channels? The Ceramide-Induced Membrane Permeabilization Mechanism. 2017 Biophys. J. pmid:28834722
Roldan N et al. Divide & Conquer: Surfactant Protein SP-C and Cholesterol Modulate Phase Segregation in Lung Surfactant. 2017 Biophys. J. pmid:28834721
Wan JY et al. Multiple Effects of Ginseng Berry Polysaccharides: Plasma Cholesterol Level Reduction and Enteric Neoplasm Prevention. 2017 Am. J. Chin. Med. pmid:28830208
Bodeen WJ et al. A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport. 2017 Development pmid:28827391
Athithan V and Srikumar K 28-Homocastasterone down regulates blood glucose, cholesterol, triglycerides, SREBP1c and activates LxR expression in normal & diabetic male rat. 2017 Chem. Biol. Interact. pmid:28822685
Tharad S et al. Bacillus thuringiensis Cyt2Aa2 binding on lipid/cholesterol bilayer depends on protein concentration and time. 2017 Biochem. Biophys. Res. Commun. pmid:28821431
Ribeiro RV et al. Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP). 2017 Br. J. Nutr. pmid:28820080
Nowacka-Woszuk J et al. Prenatal caloric restriction alters lipid metabolism but not hepatic Fasn gene expression and methylation profiles in rats. 2017 BMC Genet. pmid:28810876
Sadh K et al. Feeding-fasting dependent recruitment of membrane microdomain proteins to lipid droplets purified from the liver. 2017 PLoS ONE pmid:28800633
Carravilla P et al. Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes. 2017 Biophys. J. pmid:28797705
Kraft P et al. Hypercholesterolemia induced cerebral small vessel disease. 2017 PLoS ONE pmid:28796818
Maggi P et al. Cardiovascular risk and dyslipidemia among persons living with HIV: a review. 2017 BMC Infect. Dis. pmid:28793863
Schlabe S et al. Moderate endurance training (marathon-training) - effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project. 2017 BMC Infect. Dis. pmid:28789630
Pyrshev KA et al. Caspase-3 activation decreases lipid order in the outer plasma membrane leaflet during apoptosis: A fluorescent probe study. 2017 Biochim. Biophys. Acta pmid:28784460
Chang L et al. Fatty acid binding protein 4 is associated with stroke risk and severity in patients with acute ischemic stroke. 2017 J. Neuroimmunol. pmid:28781090
Marazzi G et al. Comparison of Low-Dose Statin Versus Low-Dose Statin + Armolipid Plus in High-Intensity Statin-Intolerant Patients With a Previous Coronary Event and Percutaneous Coronary Intervention (ADHERENCE Trial). 2017 Am. J. Cardiol. pmid:28781026
Borja MS et al. Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease. 2017 PLoS ONE pmid:28767713
Wang Z et al. Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors. 2017 PLoS ONE pmid:28767652
Fanter L et al. Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel σ receptor ligands. 2017 Bioorg. Med. Chem. pmid:28764962
Li T et al. Cholesterol derivative-based liposomes for gemcitabine delivery: preparation, in vitro, and in vivo characterization. 2017 Drug Dev Ind Pharm pmid:28760000
Holtman IR et al. Transcriptional control of microglia phenotypes in health and disease. 2017 J. Clin. Invest. pmid:28758903
Zinellu A et al. Cholesterol lowering treatment restores blood global DNA methylation in chronic kidney disease (CKD) patients. 2017 Nutr Metab Cardiovasc Dis pmid:28755807
Chadwick AC et al. In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28751571
Nelson J et al. Ultraslow dynamics of a complex amphiphile within the phospholipid bilayer: Effect of the lipid pre-transition. 2017 Biochim. Biophys. Acta pmid:28751091
Jayakar SK et al. Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma. 2017 Am. J. Pathol. pmid:28751006
Bajimaya S et al. Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses. 2017 Virology pmid:28750327
Kim JY et al. Hepatitis C Virus Induces the Localization of Lipid Rafts to Autophagosomes for Its RNA Replication. 2017 J. Virol. pmid:28747506
Han J and Wang W Effects of tanshinol on markers of bone turnover in ovariectomized rats and osteoblast cultures. 2017 PLoS ONE pmid:28746340
Loregger A et al. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28882874
Monteiro MOB et al. EFFECT OF A SHORT PERIOD WHOLE BODY VIBRATION WITH 10 HZ ON BLOOD BIOMARKERS IN RATS. 2017 Afr J Tradit Complement Altern Med pmid:28740939
González-Prendes R et al. Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle. 2017 Anim. Genet. pmid:28737243
Dabrowski J et al. Thyroid function of steatitis-affected Mozambique tilapia Oreochromis mossambicus from a sub-tropical African reservoir. 2017 Dis. Aquat. Org. pmid:28737156
Panahi Y et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial. 2017 Complement Ther Med pmid:28735818
Gupta A et al. Curcumin-3,4-Dichloro Phenyl Pyrazole (CDPP) overcomes curcumin's low bioavailability, inhibits adipogenesis and ameliorates dyslipidemia by activating reverse cholesterol transport. 2017 Metab. Clin. Exp. pmid:28732567
Larifla L et al. Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans. 2017 PLoS ONE pmid:28727855
Lim FT et al. Cholesterol lowering by Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in adult zebrafish is associated with improved memory and involves an interplay between npc1l1 and abca1. 2017 Food Funct pmid:28725889
Liu CC et al. Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells. 2017 J. Virol. pmid:28724764
Fennouri A et al. Single channel planar lipid bilayer recordings of the melittin variant MelP5. 2017 Biochim. Biophys. Acta pmid:28720433
Silva LND et al. Differences of lipid membrane modulation and oxidative stress by digoxin and 21-benzylidene digoxin. 2017 Exp. Cell Res. pmid:28720385
Bandyopadhyay S et al. Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia. 2017 PLoS ONE pmid:28719608
Espada S et al. Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages. 2017 Biochem. Biophys. Res. Commun. pmid:28712870
Ho XL and Loke WM Dietary Plant Sterols Supplementation Increases In Vivo Nitrite and Nitrate Production in Healthy Adults: A Randomized, Controlled Study. 2017 J. Food Sci. pmid:28708316
Brigham EP et al. A pilot feeding study for adults with asthma: The healthy eating better breathing trial. 2017 PLoS ONE pmid:28704419
Zhang C et al. oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27 signaling: opposite effects of oxLDL and cholesterol loading. 2017 Am. J. Physiol., Cell Physiol. pmid:28701359
Chou CL et al. Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats. 2017 PLoS ONE pmid:28700686
Masson W et al. Discordant Lipid Pattern and Carotid Atherosclerotic Plaque. Importance of Remnant Cholesterol. 2017 Arq. Bras. Cardiol. pmid:28699976
Cesena FHY et al. Cardiovascular Risk Stratification and Statin Eligibility Based on the Brazilian vs. North American Guidelines on Blood Cholesterol Management. 2017 Arq. Bras. Cardiol. pmid:28699974
Kuzu OF et al. Modulating cancer cell survival by targeting intracellular cholesterol transport. 2017 Br. J. Cancer pmid:28697173
Williams JW et al. Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. 2017 Circ. Res. pmid:28696252
Chen Q et al. Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage. 2017 Diabetes pmid:28696211
Cadamuro J et al. What´s floating on my plasma? 2017 Biochem Med (Zagreb) pmid:28694735
Erhabor JO and Idu M Aphrodisiac potentials of the ethanol extract of Aloe barbadensis Mill. root in male Wistar rats. 2017 BMC Complement Altern Med pmid:28693591
Quintana AM et al. Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. 2017 PLoS ONE pmid:28686747
Cheng YY et al. Examining the gender difference in the association between metabolic syndrome and the mean leukocyte telomere length. 2017 PLoS ONE pmid:28686726
Buschiazzo J et al. Free cholesterol and cholesterol esters in bovine oocytes: Implications in survival and membrane raft organization after cryopreservation. 2017 PLoS ONE pmid:28686720
Bamm VV et al. Potential role of ferric hemoglobin in MS pathogenesis: Effects of oxidative stress and extracellular methemoglobin or its degradation products on myelin components. 2017 Free Radic. Biol. Med. pmid:28863941
Turner KM et al. Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. 2017 Nutrients pmid:28817063
Kawamoto T et al. Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics. 2017 J Toxicol Sci pmid:28717101
Bosteen MH et al. Effects of apolipoprotein M in uremic atherosclerosis. 2017 Atherosclerosis pmid:28866363
Zhu W et al. A-type ECG and EGCG dimers inhibit 3T3-L1 differentiation by binding to cholesterol in lipid rafts. 2017 J. Nutr. Biochem. pmid:28772148
Zhu L et al. Structures of apolipoprotein A-I in high density lipoprotein generated by electron microscopy and biased simulations. 2017 Biochim. Biophys. Acta pmid:28754383
Mavioso ICVC et al. Molecular dynamics simulations of T-2410 and T-2429 HIV fusion inhibitors interacting with model membranes: Insight into peptide behavior, structure and dynamics. 2017 Biophys. Chem. pmid:28711675
Shaw SK et al. Non-Covalent Assembly Method that Simultaneously Endows a Liposome Surface with Targeting Ligands, Protective PEG Chains, and Deep-Red Fluorescence Reporter Groups. 2017 Chemistry pmid:28736857
Feng ZH et al. Effects of dietary supplementation of resveratrol on performance, egg quality, yolk cholesterol and antioxidant enzyme activity of laying hens. 2017 Br. Poult. Sci. pmid:28817948
Endo-Umeda K et al. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. 2017 J. Steroid Biochem. Mol. Biol. pmid:28736297
Smith MC et al. Zeta potential: a case study of cationic, anionic, and neutral liposomes. 2017 Anal Bioanal Chem pmid:28762066
Kim A et al. Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. 2017 Brain Res. Bull. pmid:28710022
Monzel JV et al. Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters. 2017 Biochem. Pharmacol. pmid:28807695
Mühlhäuser P et al. Structure analysis of the membrane-bound dermcidin-derived peptide SSL-25 from human sweat. 2017 Biochim. Biophys. Acta pmid:28888369
Isabettini S et al. Molecular engineering of lanthanide ion chelating phospholipids generating assemblies with a switched magnetic susceptibility. 2017 Phys Chem Chem Phys pmid:28745755
Savolainen O et al. Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of type 2 diabetes in older Swedish women. 2017 Am. J. Clin. Nutr. pmid:28903960
Koyanagi T et al. Thiol-Triggered Release of Intraliposomal Content from Liposomes Made of Extremophile-Inspired Tetraether Lipids. 2017 Bioconjug. Chem. pmid:28708392
Michalczyk A et al. Lysophosphatidic acid plasma concentrations in healthy subjects: circadian rhythm and associations with demographic, anthropometric and biochemical parameters. 2017 Lipids Health Dis pmid:28732508
Serquiña AKP et al. Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection. 2017 MBio pmid:28698273
Cornell CE et al. n-Alcohol Length Governs Shift in L-L Mixing Temperatures in Synthetic and Cell-Derived Membranes. 2017 Biophys. J. pmid:28801104
Guo N et al. Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells. 2017 Braz. J. Med. Biol. Res. pmid:28902926
Röytiö H et al. Dietary intake of fat and fibre according to reference values relates to higher gut microbiota richness in overweight pregnant women. 2017 Br. J. Nutr. pmid:28901891
Qi Y et al. Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. 2017 Appl. Environ. Microbiol. pmid:28710262
De Stefano A et al. Performance characteristics of lipoprotein-associated phospholipase A2 activity assay on the Dimension Vista analyser and preliminary study of a healthy Italian population. 2017 Biochem Med (Zagreb) pmid:28900364
Thompson D et al. Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR mouse model of atherosclerosis. 2017 Clin. Sci. pmid:28899902
Santiago PG et al. Mechanisms underlying antiatherosclerotic properties of an enriched fraction obtained from Ilex paraguariensis A. St.-Hil. 2017 Phytomedicine pmid:28899499
Sytchev VI et al. Oxysterol, 5α-cholestan-3-one, modulates a contractile response to β2-adrenoceptor stimulation in the mouse atria: Involvement of NO signaling. 2017 Life Sci. pmid:28888956
Liu N et al. Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. 2017 Biochem. Biophys. Res. Commun. pmid:28887037
Jeon JH and Lee C Cellular cholesterol is required for porcine nidovirus infection. 2017 Arch. Virol. pmid:28884395
Stepanova MА et al. Cholesterol-imprinted macroporous monoliths: Preparation and characterization. 2017 Electrophoresis pmid:28881397
Maulucci G et al. Phase separation of the plasma membrane in human red blood cells as a potential tool for diagnosis and progression monitoring of type 1 diabetes mellitus. 2017 PLoS ONE pmid:28880900
Han K et al. In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis. 2017 PLoS ONE pmid:28877164
Alioui A et al. Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. 2017 Nat Commun pmid:28874658
Klemsdal TO et al. New guidelines for the prevention of cardiovascular disease. 2017 Tidsskr. Nor. Laegeforen. pmid:28871738
Abela GS et al. Frequency of Cholesterol Crystals in Culprit Coronary Artery Aspirate During Acute Myocardial Infarction and Their Relation to Inflammation and Myocardial Injury. 2017 Am. J. Cardiol. pmid:28867129
Kim MK et al. Variability in Total Cholesterol Is Associated With the Risk of End-Stage Renal Disease: A Nationwide Population-Based Study. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28860222
Rosenson RS et al. Optimizing Cholesterol Treatment in Patients With Muscle Complaints. 2017 J. Am. Coll. Cardiol. pmid:28859793
Hou Y et al. Risk factors of periodontal disease in maintenance hemodialysis patients. 2017 Medicine (Baltimore) pmid:28858105
Bakke SS et al. Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation. 2017 J. Immunol. pmid:28855312