cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

Cross Reference

Introduction

To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with cholesterol?

cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with cholesterol

MeSH term MeSH ID Detail
Burnout, Professional D002055 1 associated lipids
Arrhythmia, Sinus D001146 1 associated lipids
Dicrocoeliasis D004011 1 associated lipids
Diabetes Insipidus, Neurogenic D020790 1 associated lipids
Needlestick Injuries D016602 1 associated lipids
Postcholecystectomy Syndrome D017562 1 associated lipids
Aortitis D001025 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with cholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with cholesterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with cholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with cholesterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with cholesterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with cholesterol?

Knock-out

Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).

Mouse Model

Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).

Disease model

Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with cholesterol

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Authors Title Published Journal PubMed Link
Xue Z et al. Potential Lipid-Lowering Mechanisms of Biochanin A. 2017 J. Agric. Food Chem. pmid:28447802
Baldissera MD et al. β-caryophyllene reduces atherogenic index and coronary risk index in hypercholesterolemic rats: The involvement of cardiac oxidative damage. 2017 Chem. Biol. Interact. pmid:28411027
Watanabe H et al. Lipid raft dynamics linked to sperm competency for fertilization in mice. 2017 Genes Cells pmid:28425215
Li X et al. Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study. 2017 BMC Complement Altern Med pmid:28420359
Xie X et al. Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux. 2017 Nutrients pmid:28505110
Di Scala C et al. Ceramide binding to anandamide increases its half-life and potentiates its cytotoxicity in human neuroblastoma cells. 2017 Chem. Phys. Lipids pmid:28389107
Edler E et al. Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region. 2017 Biochim. Biophys. Acta pmid:28455099
Javanainen M et al. Two cations, two mechanisms: interactions of sodium and calcium with zwitterionic lipid membranes. 2017 Chem. Commun. (Camb.) pmid:28453006
Tajima K et al. Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet. 2017 Am. J. Physiol. Endocrinol. Metab. pmid:28512156
Xia H et al. Effects of breviscapine on amyloid beta 1-42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study. 2017 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:28511119
Patel KK et al. Prevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys. 2017 Ann. Intern. Med. pmid:28505660
Ridker PM and Cook NR Cholesterol Evaluation in Young Adults: Absence of Clinical Trial Evidence Is Not a Reason to Delay Screening. 2017 Ann. Intern. Med. pmid:28505631
Bizoń A and Milnerowicz H The effect of passive and active exposure to tobacco smoke on lipid profile parameters and the activity of certain membrane enzymes in the blood of women in the first trimester of pregnancy. 2017 Environ. Toxicol. Pharmacol. pmid:28505474
González-Peña D et al. Role of dietary onion in modifying the faecal bile acid content in rats fed a high-cholesterol diet. 2017 Food Funct pmid:28504277
Zhang K et al. Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo. 2017 Int J Nanomedicine pmid:28503066
Al-Saiedy M et al. The role of multilayers in preventing the premature buckling of the pulmonary surfactant. 2017 Biochim. Biophys. Acta pmid:28501605
Lekic A et al. Crosstalk Between Enzyme Matrix Metalloproteinases 2 and 9 and Regulatory T Cell Immunity in the Global Burden of Atherosclerosis. 2017 Scand. J. Immunol. pmid:28500763
Luchsinger JA et al. Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study. 2017 Diabetes Care pmid:28500216
Gatticchi L et al. Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells. 2017 Biochim. Biophys. Acta pmid:28499814
Lui G et al. Brief Report: Progression of Atherosclerosis in HIV-Infected Individuals-Prospective Data From an Asian Cohort. 2017 J. Acquir. Immune Defic. Syndr. pmid:28498145
Berentzen NE et al. Pubertal Timing and Cardiometabolic Markers at Age 16 Years. 2017 J. Pediatr. pmid:28495176
Zhang X et al. Effect of lifestyle interventions on cardiovascular risk factors among adults without impaired glucose tolerance or diabetes: A systematic review and meta-analysis. 2017 PLoS ONE pmid:28493887
Luk AOY et al. Declining Trends of Cardiovascular-Renal Complications and Mortality in Type 2 Diabetes: The Hong Kong Diabetes Database. 2017 Diabetes Care pmid:28490423
Rah H et al. miR-27a and miR-449b polymorphisms associated with a risk of idiopathic recurrent pregnancy loss. 2017 PLoS ONE pmid:28489914
Kamper M et al. Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast-derived BeWo cells. 2017 Biochimie pmid:28487135
Li Y et al. Apolipoprotein C-I Polymorphism and Its Association with Serum Lipid Levels and Longevity in the Bama Population. 2017 Int J Environ Res Public Health pmid:28486432
Trzeciak BG et al. Cardiovascular risk factors determined via the Internet in 2 periods of time: 2004-2009 and 2010-2015 in Poland. 2017 Int J Occup Med Environ Health pmid:28481381
Annamalai SK and Arunachalam KD Uranium (U) bioaccumulation and its persuaded alterations on hematological, serological and histological parameters in freshwater fish Pangasius sutchi. 2017 Environ. Toxicol. Pharmacol. pmid:28477471
Akamine T et al. Significance of the Preoperative CONUT Score in Predicting Postoperative Disease-free and Overall Survival in Patients with Lung Adenocarcinoma with Obstructive Lung Disease. 2017 Anticancer Res. pmid:28476853
Rosa A et al. New insights into the antioxidant activity and cytotoxicity of arzanol and effect of methylation on its biological properties. 2017 Chem. Phys. Lipids pmid:28476462
Haslacher H et al. A combination of routine blood analytes predicts fitness decrement in elderly endurance athletes. 2017 PLoS ONE pmid:28475643
Hirata H et al. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. 2017 J. Nutr. Biochem. pmid:28501703
Yang A et al. Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis. 2017 DNA Cell Biol. pmid:28472596
Assadi SN What are the effects of psychological stress and physical work on blood lipid profiles? 2017 Medicine (Baltimore) pmid:28471984
Li XQ et al. Characteristics of diabetic nephropathy patients without diabetic retinopathy: A retrospective observational study. 2017 Medicine (Baltimore) pmid:28471980
Ailanen L et al. The metabolic syndrome in mice overexpressing neuropeptide Y in noradrenergic neurons. 2017 J. Endocrinol. pmid:28468933
Wang W et al. A voltage-dependent K channel in the lysosome is required for refilling lysosomal Ca stores. 2017 J. Cell Biol. pmid:28468834
Lai HM et al. Higher DHEAS Levels Associated with Long-Term Practicing of Tai Chi. 2017 Chin J Physiol pmid:28468030
Johnson RM et al. Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. 2017 Mol. Microbiol. pmid:28464471
Favarin BZ et al. Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization. 2017 Colloids Surf B Biointerfaces pmid:28472750
Sookoian S and Pirola CJ Systematic review with meta-analysis: risk factors for non-alcoholic fatty liver disease suggest a shared altered metabolic and cardiovascular profile between lean and obese patients. 2017 Aliment. Pharmacol. Ther. pmid:28464369
Ichikawa Y et al. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits. 2017 PLoS ONE pmid:28498861
Milovanović I et al. Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results. 2017 PLoS ONE pmid:28459857
Shokryazdan P et al. Effects of a Lactobacillus salivarius mixture on performance, intestinal health and serum lipids of broiler chickens. 2017 PLoS ONE pmid:28459856
Mizowaki Y et al. Comparison of the Effects of the 1975 Japanese Diet and the Modern Mediterranean Diet on Lipid Metabolism in Mice. 2017 J Oleo Sci pmid:28458388
Silva RVG et al. Correlation between therapy and lipid profile of leprosy patients: is there a higher risk for developing cardiovascular diseases after treatment? 2017 Infect Dis Poverty pmid:28457229
Rieke S et al. Mixture effects of azole fungicides on the adrenal gland in a broad dose range. 2017 Toxicology pmid:28454766
Takishita K et al. Genomic Evidence that Methanotrophic Endosymbionts Likely Provide Deep-Sea Bathymodiolus Mussels with a Sterol Intermediate in Cholesterol Biosynthesis. 2017 Genome Biol Evol pmid:28453654
Rinne P et al. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. 2017 Circulation pmid:28450348
Rajamannan NM and Nattel S Aortic Vascular Calcification: Cholesterol Lowering Does Not Reduce Progression in Patients With Familial Hypercholesterolemia-or Does It? 2017 Can J Cardiol pmid:28449831
García-Fernández J et al. Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis. 2017 Environ. Microbiol. pmid:28447386
Wudiri GA and Nicola AV Cellular Cholesterol Facilitates the Postentry Replication Cycle of Herpes Simplex Virus 1. 2017 J. Virol. pmid:28446672
Montanholi YR et al. Liver morphometrics and metabolic blood profile across divergent phenotypes for feed efficiency in the bovine. 2017 Acta Vet. Scand. pmid:28446193
Huang H et al. Serum apoprotein A1 levels are inversely associated with disease activity in gout: From a southern Chinese Han population. 2017 Medicine (Baltimore) pmid:28445313
Scartezini M et al. Positioning about the Flexibility of Fasting for Lipid Profiling. 2017 Arq. Bras. Cardiol. pmid:28443960
Dimova LG et al. Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice. 2017 Gastroenterology pmid:28438611
van Heerden SM and Strydom PE Nutrient retention values and cooking yield factors for three South African lamb and mutton cuts. 2017 J. Sci. Food Agric. pmid:28436039
Girotti AW and Korytowski W Cholesterol Hydroperoxide Generation, Translocation, and Reductive Turnover in Biological Systems. 2017 Cell Biochem. Biophys. pmid:28434137
Meeusen JW et al. Lipid Biomarkers for Risk Assessment in Acute Coronary Syndromes. 2017 Curr Cardiol Rep pmid:28432661
Miyazaki T and Miyazaki A Emerging roles of calpain proteolytic systems in macrophage cholesterol handling. 2017 Cell. Mol. Life Sci. pmid:28432377
Reuter C et al. Evaluation of Cholesterol as a Biomarker for Suicidality in a Veteran Sample. 2017 Res Nurs Health pmid:28431193
Moyama S et al. Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged adults in Japan. 2017 Asia Pac J Clin Nutr pmid:28429921
Ouimet M et al. microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis. 2017 Arterioscler. Thromb. Vasc. Biol. pmid:28428217
Wang X et al. Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma. 2017 Cancer Lett. pmid:28428074
Cheon SY et al. HVC1 ameliorates hyperlipidemia and inflammation in LDLR mice. 2017 BMC Complement Altern Med pmid:28427397
Klouda J et al. Non-Enzymatic Electrochemistry in Characterization and Analysis of Steroid Compounds. 2017 Crit Rev Anal Chem pmid:28426249
Meyer AF et al. Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. 2017 Biochim. Biophys. Acta pmid:28472616
Upadhyaya B et al. Prenatal Exposure to a Maternal High-Fat Diet Affects Histone Modification of Cardiometabolic Genes in Newborn Rats. 2017 Nutrients pmid:28425976
Gao XQ et al. β-Adrenoceptor activation upregulates apolipoprotein A-I expression in HepG2 cells, which might further promote cholesterol efflux from macrophage foam cells. 2017 Drug Des Devel Ther pmid:28424539
Uysal S et al. [Dyslipidemia and cardiovascular risk assessment in HIV-positive patients]. 2017 Turk Kardiyol Dern Ars pmid:28424436
Sniderman AD et al. Statins, PCSK9 inhibitors and cholesterol homeostasis: a view from within the hepatocyte. 2017 Clin. Sci. pmid:28424373
Wells S et al. The impact of a point-of-care testing device on CVD risk assessment completion in New Zealand primary-care practice: A cluster randomised controlled trial and qualitative investigation. 2017 PLoS ONE pmid:28422968
Chen YW et al. Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry. 2017 PLoS ONE pmid:28422955
Zhang M et al. The levels of triglyceride and total cholesterol in methamphetamine dependence. 2017 Medicine (Baltimore) pmid:28422859
Zidan AS et al. Optimization of methotrexate loaded niosomes by Box-Behnken design: an understanding of solvent effect and formulation variability. 2017 Drug Dev Ind Pharm pmid:28420295
Pagidipati NJ et al. Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines. 2017 JAMA pmid:28418481
Subczynski WK et al. High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review. 2017 Cell Biochem. Biophys. pmid:28417231
Audetat KA et al. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. 2017 Mol. Cell. Biol. pmid:28416637
Nus M et al. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. 2017 Nat. Med. pmid:28414328
Anuradha A and Krishna Prolactin modulates luteal activity in the short-nosed fruit bat, Cynopterus sphinx during delayed embryonic development. 2017 Gen. Comp. Endocrinol. pmid:28412388
Wu IH et al. Restrictive Spirometry Pattern Is Associated With Increased Arterial Stiffness in Men and Women. 2017 Chest pmid:28411113
Gonzalez B et al. Tau Spread, Apolipoprotein E, Inflammation, and More: Rapidly Evolving Basic Science in Alzheimer Disease. 2017 Neurol Clin pmid:28410655
Azzini E et al. Effect of Red Orange Juice Consumption on Body Composition and Nutritional Status in Overweight/Obese Female: A Pilot Study. 2017 Oxid Med Cell Longev pmid:28408969
Liu W et al. Kinetic stability and membrane structure of liposomes during in vitro infant intestinal digestion: Effect of cholesterol and lactoferrin. 2017 Food Chem pmid:28407956
Teong B et al. Liposomal Encapsulation for Systemic Delivery of Propranolol via Transdermal Iontophoresis Improves Bone Microarchitecture in Ovariectomized Rats. 2017 Int J Mol Sci pmid:28406442
van Doorn D et al. Farmers Have Hearts: The Prevalence of Risk Factors for Cardiovascular Disease Among a Subgroup of Irish Livestock Farmers. 2017 J Agromedicine pmid:28406370
Zhao JY et al. An integrated method of therapeutic lifestyle change for older adults with dyslipidaemia. 2017 Public Health pmid:28404531
Lepsch J et al. Association between early pregnancy vitamin D status and changes in serum lipid profiles throughout pregnancy. 2017 Metab. Clin. Exp. pmid:28403948
Saha AK et al. Cholesterol Regulates Monocyte Rolling through CD44 Distribution. 2017 Biophys. J. pmid:28402890
Guo XF et al. The effects of Lycium barbarum L. (L. barbarum) on cardiometabolic risk factors: a meta-analysis of randomized controlled trials. 2017 Food Funct pmid:28401234
Budelier MM et al. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. 2017 J. Biol. Chem. pmid:28396346
Li Y et al. A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2. 2017 Hepatology pmid:28395113
Zibaeenezhad MJ et al. Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial. 2017 Nutr Diabetes pmid:28394361
Gisterå A and Hansson GK The immunology of atherosclerosis. 2017 Nat Rev Nephrol pmid:28392564
Graudal NA et al. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. 2017 Cochrane Database Syst Rev pmid:28391629
Chernov KG et al. Introducing inducible fluorescent split cholesterol oxidase to mammalian cells. 2017 J. Biol. Chem. pmid:28391244
Mistry HD et al. Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. 2017 J. Lipid Res. pmid:28396342
Shrestha BK et al. In situ synthesis of cylindrical spongy polypyrrole doped protonated graphitic carbon nitride for cholesterol sensing application. 2017 Biosens Bioelectron pmid:28390320
Cheng F et al. Effect of traditional Chinese medicine formula Sinisan on chronic restraint stress-induced nonalcoholic fatty liver disease: a rat study. 2017 BMC Complement Altern Med pmid:28388904
Wilck N et al. The Effect of Low-Dose Proteasome Inhibition on Pre-Existing Atherosclerosis in LDL Receptor-Deficient Mice. 2017 Int J Mol Sci pmid:28387708