cholesterol

cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.

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Introduction

To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with cholesterol?

cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with cholesterol

MeSH term MeSH ID Detail
Burnout, Professional D002055 1 associated lipids
Arrhythmia, Sinus D001146 1 associated lipids
Dicrocoeliasis D004011 1 associated lipids
Diabetes Insipidus, Neurogenic D020790 1 associated lipids
Needlestick Injuries D016602 1 associated lipids
Postcholecystectomy Syndrome D017562 1 associated lipids
Aortitis D001025 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with cholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with cholesterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with cholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with cholesterol?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with cholesterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with cholesterol?

Knock-out

Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).

Mouse Model

Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).

Disease model

Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with cholesterol

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Per page 10 20 50 100 | Total 171571
Authors Title Published Journal PubMed Link
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Makarova AM et al. Attenuation of UVR-induced vitamin D synthesis in a mouse model deleted for keratinocyte lathosterol 5-desaturase. 2017 J. Steroid Biochem. Mol. Biol. pmid:28330720
Vujic N et al. Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. 2017 Oncotarget pmid:28380440
Brown KA et al. Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers. 2017 J. Clin. Endocrinol. Metab. pmid:28323914
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Huang X et al. pH-sensitive micelles self-assembled from polymer brush (PAE--cholesterol)--PEG--(PAE--cholesterol) for anticancer drug delivery and controlled release. 2017 Int J Nanomedicine pmid:28356738
Xu J et al. A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats. 2017 Nutrients pmid:28335388
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Daneshmand R et al. Associations of estimated Δ-5-desaturase and Δ-6-desaturase activities with stroke risk factors and risk of stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. 2017 Br. J. Nutr. pmid:28382895
Uchida Y Recent Advances in Fluorescent Angioscopy for Molecular Imaging of Human Atherosclerotic Coronary Plaque. 2017 J. Atheroscler. Thromb. pmid:28381766
Naglich AC et al. Plasma Insulin Level Correlation to Metabolic Parameter Shifts in Hospitalized Psychiatric Patients. 2017 Prim Care Companion CNS Disord pmid:28387485
Benedini S et al. Irisin: A Potential Link between Physical Exercise and Metabolism-An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People. 2017 J Diabetes Res pmid:28386566
Carrasco-Pozo C et al. Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreatic -Cells Function. 2017 Oxid Med Cell Longev pmid:28386307
Ciocan RA et al. Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia. 2017 Folia Med (Plovdiv) pmid:28384111
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Sakai T et al. Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet. 2017 Biol. Pharm. Bull. pmid:28381793
Skrede T et al. Moderate-to-vigorous physical activity, but not sedentary time, predicts changes in cardiometabolic risk factors in 10-y-old children: the Active Smarter Kids Study. 2017 Am. J. Clin. Nutr. pmid:28381476
Borgquist S et al. Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study. 2017 J. Clin. Oncol. pmid:28380313
Cantelli KR et al. Duodenal-jejunal bypass normalizes pancreatic islet proliferation rate and function but not hepatic steatosis in hypothalamic obese rats. 2017 Braz. J. Med. Biol. Res. pmid:28380195
Rijks JM et al. Association of TSH With Cardiovascular Disease Risk in Overweight and Obese Children During Lifestyle Intervention. 2017 J. Clin. Endocrinol. Metab. pmid:28379580
Canterini S et al. Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease. 2017 Hum. Mol. Genet. pmid:28379564
Hashimoto N et al. Intraduodenal infusion of cyanidin-3-glucoside transiently promotes triglyceride excretion into bile in rats. 2017 Nutr Res pmid:28381352
Hubacek JA et al. Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor. 2017 Physiol Res pmid:28379037
Dlouhá D and Hubáček JA Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs. 2017 Physiol Res pmid:28379027
Gao Y et al. Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis. 2017 J. Biol. Chem. pmid:28377508
Wilhelm LP et al. STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. 2017 EMBO J. pmid:28377464
Bukiya AN and Rosenhouse-Dantsker A Synergistic activation of G protein-gated inwardly rectifying potassium channels by cholesterol and PI(4,5)P. 2017 Biochim. Biophys. Acta pmid:28377218
Gulati S et al. Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study. 2017 Lipids Health Dis pmid:28376899