| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diarrhea | D003967 | 32 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Uterine Cervical Neoplasms | D002583 | 10 associated lipids |
| Neoplasms, Experimental | D009374 | 10 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
cholesterol
cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.
Cross Reference
Introduction
To understand associated biological information of cholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with cholesterol?
cholesterol is suspected in Atherosclerosis, Hypercholesterolemia, cholesterol gallstones, Obesity, SVEINSSON CHORIORETINAL ATROPHY, Congenital Abnormality and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with cholesterol
PubChem Associated disorders and diseases
What pathways are associated with cholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with cholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with cholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with cholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with cholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with cholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with cholesterol?
Knock-out
Knock-out are used in the study 'Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.' (Leventhal AR et al., 2001), Knock-out are used in the study 'On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice.' (Ali Z et al., 2013), Knock-out are used in the study 'Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.' (Xu G et al., 1998), Knock-out are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010) and Knock-out are used in the study 'Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.' (Schwarz M et al., 1998).
Mouse Model
Mouse Model are used in the study 'Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.' (Valasek MA et al., 2007), Mouse Model are used in the study 'Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.' (Johnston JB et al., 2010), Mouse Model are used in the study 'Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.' (Wang DQ et al., 1999), Mouse Model are used in the study 'Feedback inhibition of the cholesterol biosynthetic pathway in patients with Smith-Lemli-Opitz syndrome as demonstrated by urinary mevalonate excretion.' (Pappu AS et al., 2002) and Mouse Model are used in the study 'Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.' (Herman GE, 2003).
Disease model
Disease model are used in the study 'Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities.' (Ramaswamy M et al., 2001) and Disease model are used in the study 'Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.' (Wooton-Kee CR et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with cholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leng E et al. | Synergistic effect of phytochemicals on cholesterol metabolism and lipid accumulation in HepG2 cells. | 2018 | BMC Complement Altern Med | pmid:29622007 |
| Donaldson SH and de Aguiar HB | Molecular Imaging of Cholesterol and Lipid Distributions in Model Membranes. | 2018 | J Phys Chem Lett | pmid:29521507 |
| Fraz S et al. | Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). | 2018 | Aquat. Toxicol. | pmid:29494825 |
| Heitzig N et al. | Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. | 2018 | Biochim Biophys Acta Mol Cell Biol Lipids | pmid:29306076 |
| Hoseini Z et al. | NLRP3 inflammasome: Its regulation and involvement in atherosclerosis. | 2018 | J. Cell. Physiol. | pmid:28345767 |
| Simonen P et al. | Desmosterol accumulation in users of amiodarone. | 2018 | J. Intern. Med. | pmid:28861933 |
| Plesnar E et al. | Is the cholesterol bilayer domain a barrier to oxygen transport into the eye lens? | 2018 | Biochim Biophys Acta Biomembr | pmid:29079282 |
| Formichi P et al. | Primary cilium alterations and expression changes of Patched1 proteins in niemann-pick type C disease. | 2018 | J. Cell. Physiol. | pmid:28332184 |
| Safar HA et al. | Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus. | 2018 | J. Steroid Biochem. Mol. Biol. | pmid:28323045 |
| Johnson QR et al. | Effects of carotenoids on lipid bilayers. | 2018 | Phys Chem Chem Phys | pmid:29349456 |
| Both T et al. | Hydroxychloroquine affects bone resorption both in vitro and in vivo. | 2018 | J. Cell. Physiol. | pmid:28556961 |
| Samardzija D et al. | Bisphenol A decreases progesterone synthesis by disrupting cholesterol homeostasis in rat granulosa cells. | 2018 | Mol. Cell. Endocrinol. | pmid:28859904 |
| Ruan B et al. | Cholesterol inhibits entotic cell-in-cell formation and actomyosin contraction. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29198709 |
| Agrawal S et al. | Dyslipidaemia in nephrotic syndrome: mechanisms and treatment. | 2018 | Nat Rev Nephrol | pmid:29176657 |
| Yamamoto Y et al. | Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29162448 |
| Shigematsu T et al. | Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer. | 2018 | J Phys Chem B | pmid:29419298 |
| Lu DL et al. | Reproducibility of serum oxysterols and lanosterol among postmenopausal women: Results from EPIC-Heidelberg. | 2018 | Clin. Biochem. | pmid:29108727 |
| Rajan S et al. | Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/β-catenin pathway. | 2018 | Eur J Med Chem | pmid:29153558 |
| Panchoo M and Lacko A | Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29128352 |
| Chen L et al. | Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29122594 |
| Gilbert S et al. | Characterization of an Aldolase Involved in Cholesterol Side Chain Degradation in Mycobacterium tuberculosis. | 2018 | J. Bacteriol. | pmid:29109182 |
| Stoeck IK et al. | Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis. | 2018 | J. Virol. | pmid:29046459 |
| Singh K and Chan HM | Association of blood polychlorinated biphenyls and cholesterol levels among Canadian Inuit. | 2018 | Environ. Res. | pmid:29035785 |
| Asif M et al. | TG haplotype in the LRP8 is associated with myocardial infarction in south Indian population. | 2018 | Gene | pmid:29032149 |
| Singh P et al. | PDIM and SL1 accumulation in Mycobacterium tuberculosis is associated with mce4A expression. | 2018 | Gene | pmid:28988960 |
| Lin Y et al. | Oxidation of sitosterol and campesterol in foods upon cooking with liquid margarines without and with added plant sterol esters. | 2018 | Food Chem | pmid:28958544 |
| Bhojoo U et al. | Temperature induced lipid membrane restructuring and changes in nanomechanics. | 2018 | Biochim. Biophys. Acta | pmid:29248477 |
| Crowson CS et al. | Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis. | 2018 | Ann. Rheum. Dis. | pmid:28877868 |
| Liu S et al. | Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28108177 |
| Doktorova M et al. | Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties. | 2017 | Biophys. J. | pmid:29117524 |
| Feng D et al. | Bisphenol A promotes cholesterol absorption in Caco-2 cells by up-regulation of NPC1L1 expression. | 2017 | Lipids Health Dis | pmid:28057006 |
| Thyagarajan B et al. | Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice. | 2017 | Toxicol. Sci. | pmid:28645175 |
| Wang Y et al. | Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice. | 2017 | Cell Mol Gastroenterol Hepatol | pmid:28275691 |
| Costabile A et al. | An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults. | 2017 | PLoS ONE | pmid:29228000 |
| Rouviere E et al. | Identification of Two New Cholesterol Interaction Sites on the A Adenosine Receptor. | 2017 | Biophys. J. | pmid:29211995 |
| de Candia P et al. | A unique plasma microRNA profile defines type 2 diabetes progression. | 2017 | PLoS ONE | pmid:29200427 |
| Alsubheen SA et al. | The effects of diurnal Ramadan fasting on energy expenditure and substrate oxidation in healthy men. | 2017 | Br. J. Nutr. | pmid:29198194 |
| Guimarães KSL et al. | Effect of maternal dyslipidaemia on the cardiorespiratory physiology and biochemical parameters in male rat offspring. | 2017 | Br. J. Nutr. | pmid:29173205 |
| Chalmers AD et al. | Nonlinear dynamics of early atherosclerotic plaque formation may determine the efficacy of high density lipoproteins (HDL) in plaque regression. | 2017 | PLoS ONE | pmid:29161303 |
| Wang SH et al. | Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. | 2017 | PLoS ONE | pmid:29161294 |
| Petta S et al. | Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS. | 2017 | PLoS ONE | pmid:29161258 |
| Lucas JE et al. | An electronic health record based model predicts statin adherence, LDL cholesterol, and cardiovascular disease in the United States Military Health System. | 2017 | PLoS ONE | pmid:29155848 |
| Lee G et al. | Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. | 2017 | Cell | pmid:29153836 |
| Widenmaier SB et al. | NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. | 2017 | Cell | pmid:29149604 |
| Khondker A et al. | Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs. | 2017 | Biophys. J. | pmid:29117525 |
| Hayward N et al. | U-shaped relationship between serum phosphate and cardiovascular risk: A retrospective cohort study. | 2017 | PLoS ONE | pmid:29117214 |
| Wang Y et al. | Barley β-glucan reduces blood cholesterol levels via interrupting bile acid metabolism. | 2017 | Br. J. Nutr. | pmid:29115200 |
| Michos ED et al. | Use of the Coronary Artery Calcium Score in Discussion of Initiation of Statin Therapy in Primary Prevention. | 2017 | Mayo Clin. Proc. | pmid:29108840 |
| Koka S et al. | Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia. | 2017 | Redox Biol | pmid:28633109 |
| Tiburcio TC et al. | Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. | 2017 | Clin. Exp. Pharmacol. Physiol. | pmid:27859493 |