24(S),25-Epoxycholesterol

24(S),25-Epoxycholesterol is a lipid of Sterol Lipids (ST) class.

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Current reference collection contains 285 references associated with 24(S),25-Epoxycholesterol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Endo-Umeda K et al. 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. 2017 J. Steroid Biochem. Mol. Biol. pmid:28736297
Wang Z et al. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. 2017 Arch. Toxicol. pmid:27052460
Hong YF et al. Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. 2016 PLoS ONE pmid:27120199
Bentinger M et al. Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis. 2014 Biochim. Biophys. Acta pmid:24747199
Wang Y et al. 24S,25-Epoxycholesterol in mouse and rat brain. 2014 Biochem. Biophys. Res. Commun. pmid:24832732
Meljon A et al. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. 2014 Biochem. Biophys. Res. Commun. pmid:24491562
Javitt NB Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing. 2013 J. Alzheimers Dis. pmid:23455994
Mazein A et al. A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway. 2013 Biochem. Pharmacol. pmid:23583456
Theofilopoulos S et al. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. 2013 Nat. Chem. Biol. pmid:23292650
Zerenturk EJ et al. The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1). 2012 Biochim. Biophys. Acta pmid:22178193
Zeng J et al. Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner. 2012 Antiviral Res. pmid:22713431
Fukunaga M et al. Mast cell death induced by 24(S),25-epoxycholesterol. 2010 Exp. Cell Res. pmid:20854813
Moya M et al. Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. 2010 Chem. Biol. Interact. pmid:20079722
Ando H et al. Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro. 2010 Biochim. Biophys. Acta pmid:20045741
Brown AJ and Jessup W Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis. 2009 Mol. Aspects Med. pmid:19248801
Trasino SE et al. Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. 2009 Mol. Cancer Ther. pmid:19531574
Swahn BM et al. Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides. 2009 Bioorg. Med. Chem. Lett. pmid:19264481
Brown AJ 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis. 2009 Int. J. Biochem. Cell Biol. pmid:18725318
Morello F et al. LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. 2009 Atherosclerosis pmid:19426978
Wong J et al. Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis. 2008 J. Biol. Chem. pmid:17981807
Ouimet M et al. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18369155
Cheng JF et al. Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators. 2008 J. Med. Chem. pmid:18324758
Reschly EJ et al. Ligand specificity and evolution of liver X receptors. 2008 J. Steroid Biochem. Mol. Biol. pmid:18395439
Wong J et al. Primary human astrocytes produce 24(S),25-epoxycholesterol with implications for brain cholesterol homeostasis. 2007 J. Neurochem. pmid:17956548
Duniec-Dmuchowski Z et al. Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists. 2007 Biochem. Pharmacol. pmid:17825266
Heverin M et al. Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17761942
Zapata-Gonzalez F et al. 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. 2007 J. Immunol. pmid:17475839
Beyea MM et al. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. 2007 J. Biol. Chem. pmid:17186944
Wong J et al. SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR. 2006 Biochem. J. pmid:16901265
Li L et al. Discovery and optimization of a novel series of liver X receptor-alpha agonists. 2006 Bioorg. Med. Chem. Lett. pmid:16386417
Davies JD et al. Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. 2005 J. Biol. Chem. pmid:15548517
Wong J et al. Statins inhibit synthesis of an oxysterol ligand for the liver x receptor in human macrophages with consequences for cholesterol flux. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15514210
Bjorkhem I and Diczfalusy U 24(S),25-epoxycholesterol--a potential friend. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15576644
Rowe AH et al. Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation. 2003 Circ. Res. pmid:14512442
Williams S et al. X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. 2003 J. Biol. Chem. pmid:12736258
Kaneko E et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. 2003 J. Biol. Chem. pmid:12847102
Kömüves LG et al. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. 2002 J. Invest. Dermatol. pmid:11851872
Ou J et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11371634
Spencer TA et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. 2001 J. Med. Chem. pmid:11300870
Zhang Z et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. 2001 J. Lipid Res. pmid:11290837
Li D and Spencer TA Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. 2000 Steroids pmid:10978732
Janowski BA et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874807
Lehmann JM et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. 1997 J. Biol. Chem. pmid:9013544
Dollis D and Schuber F Effects of a 2,3-oxidosqualene-lanosterol cyclase inhibitor 2,3:22,23-dioxidosqualene and 24,25-epoxycholesterol on the regulation of cholesterol biosynthesis in human hepatoma cell line HepG2. 1994 Biochem. Pharmacol. pmid:8043030
Saucier SE et al. Hepatic uptake and metabolism of ingested 24-hydroxycholesterol and 24(S),25-epoxycholesterol. 1993 Biochim. Biophys. Acta pmid:8431485
Panini SR et al. Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by 24(S),25-oxidolanosterol. 1992 J. Biol. Chem. pmid:1618770
Emmons GT et al. 24,25-epoxysterols. Differentiation of 24R and 24S epimers by 13C nuclear magnetic resonance spectroscopy. 1989 J. Lipid Res. pmid:2918248
Panini SR et al. Regulation of sterol biosynthesis and of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in cultured cells by progesterone. 1987 J. Biol. Chem. pmid:3667583
Taylor FR et al. 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase. 1986 J. Biol. Chem. pmid:3771561
Gupta A et al. Modulation of regulatory oxysterol formation and low density lipoprotein suppression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by ketoconazole. A role for cytochrome P-450 in the regulation of HMG-CoA reductase in rat intestinal epithelial cells. 1986 J. Biol. Chem. pmid:3722155